Lrrk2 - leucine-rich repeat kinase 2 Gene

Mus musculus

Also known as Gm927; cI-46; 4921513O20Rik; 9330188B09Rik; D630001M17Rik

Gene ID: 66725 | Gene type: protein coding

About Lrrk2

Chromosome 15: 91,557,378-91,700,323 forward strand.GRCm39:CM001008.3

This gene has 6 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 52 phenotypes. Broad expression in kidney adult (RPKM 2.7), lung adult (RPKM 2.3) and 24 other tissues.

Summary

Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of cellular catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including Golgi organization; positive regulation of histone deacetylase activity; and protein import into nucleus. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including autopod; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk2 Products(1)

mRNA	Protein	Name
NM_025730.3	NP_080006.3	leucine-rich repeat serine/threonine-protein kinase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin destruction complex binding	IPI IPI: Inferred from physical interaction	22899650	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	21390248	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21048939	MGI
enables protein kinase A binding	IPI IPI: Inferred from physical interaction	24464040	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	24510904	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	27798112	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	27798112	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	21048939	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Golgi organization	IGI IGI: Inferred from genetic interaction	24510904	MGI
involved in endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	25201882	MGI
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	24464040	MGI
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	24464040	MGI
involved in locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	24464040	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	26355680	MGI
involved in negative regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21307259	MGI
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	26355680	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	20457918	MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20457918	MGI
acts upstream of or within protein import into nucleus	IDA IDA: Inferred from direct assay	27798112	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	27798112	MGI
involved in protein localization	IMP IMP: Inferred from mutant phenotype	24464040	MGI
involved in protein localization to endoplasmic reticulum exit site	IMP IMP: Inferred from mutant phenotype	25201882	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	27798112	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	27798112	MGI
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	28720718	MGI
involved in regulation of ER to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	25201882	MGI
involved in regulation of cAMP/PKA signal transduction	IMP IMP: Inferred from mutant phenotype	24464040	MGI
involved in regulation of canonical Wnt signaling pathway	IPI IPI: Inferred from physical interaction	22899650	MGI
involved in regulation of dendritic spine morphogenesis	IGI IGI: Inferred from genetic interaction	24464040	MGI
involved in regulation of dopamine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24464040	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24427314	MGI
involved in regulation of kidney size	IMP IMP: Inferred from mutant phenotype	20457918	MGI
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	24464040	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	25501810	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	25501810	MGI
involved in regulation of synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	21307259	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17120249	MGI
part of Wnt signalosome	IDA IDA: Inferred from direct assay	22899650	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	27273569	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17120249	MGI
located in dendrite	IDA IDA: Inferred from direct assay	24464040	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17120249	MGI
located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	25201882	MGI
located in endosome	IDA IDA: Inferred from direct assay	17120249	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25501810	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	25501810	MGI
located in lysosome	IDA IDA: Inferred from direct assay	17120249	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	17341485	MGI
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	17120249	MGI
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	17120249	MGI
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	17120249	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17341485	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	17341485	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	24427314	MGI
located in synapse	IDA IDA: Inferred from direct assay	22423108	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	17341485	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	17341485	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lrrk2 Protein Structure

LRR_RI

PRK15370

LRR_RI

RocCOR

COR

STKc_LRRK2

0
400
800
1200
1600
2000
2400
2527 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat serine/threonine-protein kinase 2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112809	GSK2646264	Inhibitor	98.39%	Phase 1

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100411	MLi-2	Inhibitor	99.80%	Unkown
HY-13687	IKK 16	Inhibitor	99.88%	Unkown
HY-10875	LRRK2-IN-1	Inhibitor	99.42%	Unkown
HY-12477	PF-06447475	Inhibitor	99.94%	Unkown
HY-15796	GNE0877	Inhibitor	99.81%	Unkown
HY-148030	XL01126	Inhibitor	98.65%	Unkown
HY-18163	GNE-7915	Inhibitor	99.82%	Unkown
HY-13237	GSK2578215A	Inhibitor	99.78%	Unkown
HY-40294	Indazole	Inhibitor	99.72%	Unkown
HY-120085	PFE-360	Inhibitor	99.48%	Unkown
HY-13488	HG-10-102-01	Inhibitor	99.55%	Unkown
HY-13687A	IKK 16 hydrochloride	Inhibitor	99.95%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-12282	GNE-9605	Inhibitor	99.72%	Unkown
HY-16936	JH-II-127	Inhibitor	≥98.0%	Unkown
HY-B0792	CZC-54252	Inhibitor	99.38%	Unkown
HY-112855	PF-06454589	Inhibitor	99.91%	Unkown
HY-163064	CC-3240	Degrader	98.23%	Unkown
HY-142647	EB-42486	Inhibitor	99.62%	Unkown
HY-152107	LRRK2-IN-7	Inhibitor	98.04%	Unkown
HY-156429	MK-1468	Inhibitor	99.69%	Unkown
HY-111493	LRRK2 inhibitor 1	Inhibitor	99.93%	Unkown
HY-155150	JH-XII-03-02	Inhibitor	99.41%	Unkown
HY-18163A	GNE-7915 tosylate	Inhibitor	99.69%	Unkown
HY-145317	LRRK2-IN-2	Inhibitor	/	Unkown
HY-151444	LRRK2-IN-6	Inhibitor	/	Unkown
HY-151441	LRRK2-IN-5	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-148353	PF-06455943	Inhibitor	/	Unkown
HY-162699	LY2023-001	Inhibitor	/	Unkown
HY-134562	PF-06371900	Inhibitor	/	Unkown
HY-144074	LRRK2-IN-4	Inhibitor	/	Unkown
HY-168041	LRRK2-IN-15	Inhibitor	/	Unkown
HY-152107A	(R,R)-LRRK2-IN-7	Inhibitor	/	Unkown
HY-169576	LRRK2-IN-16	Inhibitor	/	Unkown
HY-161570	LRRK2-IN-12	Inhibitor	/	Unkown
HY-145318	LRRK2-IN-3	Inhibitor	/	Unkown
HY-B0792A	CZC-54252 hydrochloride	Inhibitor	98.44%	Unkown
HY-161571	LRRK2-IN-13	Inhibitor	/	Unkown
HY-156167	LRRK2-IN-10	Inhibitor	/	Unkown
HY-158365	LRRK2-IN-14	Inhibitor	/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown
HY-P10636	Nictide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrrk2	NCBI	NCBI:120892

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