SSTR3 - somatostatin receptor 3 Gene

Homo sapiens

Also known as SS3R; SST3; SS3-R; SS-3-R; SSR-28

Gene ID: 6753 | Gene type: protein coding

About SSTR3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,204,237-37,220,548 (from NCBI)

This gene has 2 transcripts (splice variants), 251 orthologues and 17 paralogues. Biased expression in testis (RPKM 3.5), brain (RPKM 1.1) and 8 other tissues.

Summary

This gene encodes a member of the Somatostatin Receptor protein family. Somatostatins are peptide Hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many Hormones and Other secretory proteins. Somatostatin has two active forms of 14 and 28 Amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with Other members of the superfamily as well as with Other G-protein coupled receptors and Receptor Tyrosine Kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

SSTR3 Products(6)

mRNA	Protein	Name
XM_006724311.4	XP_006724374.1	somatostatin receptor type 3 isoform X1
XM_047441473.1	XP_047297429.1	somatostatin receptor type 3 isoform X1
XM_005261721.5	XP_005261778.1	somatostatin receptor type 3 isoform X1
NM_001051.5	NP_001042.1	somatostatin receptor type 3
XM_017028924.2	XP_016884413.1	somatostatin receptor type 3 isoform X1
NM_001278687.2	NP_001265616.1	somatostatin receptor type 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19071123	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSTR3 Protein Structure

7tm_1

0
100
200
300
418 a.a.

Protein Preferred Names

Protein Names

somatostatin receptor type 3

SSTR3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SSTR3	P32745	SSTR2	Homo sapiens	P30874	IF	22651821
Intra	SSTR3	P32745	MPDZ	Homo sapiens	O75970	Anti Bait CoIP	19071123
Intra	SSTR3	P32745	MPDZ	Homo sapiens	O75970	IF	19071123
Cross	SSTR3	P32745	Mpdz	Rattus norvegicus	O55164	Pull Down	19071123

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meckel Syndrome, Type 1

Meckel Syndrome	Meckel-Gruber Syndrome
Dysencephalia Splanchnocystica	Meckel Syndrome 1
MKS1	Mks
Gruber Syndrome	Meckel-Gruber Syndrome, Type 1
Mes	Dysencephalia Splachnocystica
Meckel Gruber Syndrome	Meckel Syndrome Type 1

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour	Malignant Gastrointestinal Neuroendocrine Tumor
Malignant Gastrointestinal Neuroendocrine Tumour	Digestive System Neuroendocrine Neoplasm
Digestive System Neuroendocrine Tumor

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Vipoma

Wdha Syndrome	Pancreatic Cholera
Pancreatic Vipoma	Verner-Morrison Syndrome
Diarrheogenic Islet Cell Tumor	Vip-Secreting Tumor
Malignant Vasoactive Intestinal Peptide-Secreting Tumor	Vasoactive Intestinal Peptide-Secreting Tumor
Vip- Secreting Tumor	Vipoma, Malignant
Vipoma Syndrome	Watery Diarrhea Syndrome
Watery Diarrhea, Hypokalemia, And Achlorhydria Syndrome	Vasoactive Intestinal Peptide Tumor
Vasoactive Intestinal Peptide-Producing Tumor	Watery Diarrhea-Hypokalemia-Achlorhydria Syndrome
Malignant Vipoma

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma	Prolactin-Secreting Pituitary Adenoma
Forbes-Albright Syndrome	Lactotroph Adenoma
Prl-Secreting Pituitary Adenoma	Prloma
Pituitary Lactotrophic Adenoma	Familial Prolactinoma
Pituitary Adenoma, Prolactin-Secreting	Prolactinoma Of Pituitary Gland
PSPA

Microcystic Meningioma

Pituitary Adenoma

Pituitary Neoplasms	Adenoma Of The Pituitary Gland
Pituitary Adenomas	Adenoma, Pituitary
Pituitary Gland Adenoma

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Hormone Producing Pituitary Cancer

Growth Hormone Producing Pituitary Tumor	Pituitary Tumors, Hormone Producing
Somatotropinoma	Growth Hormone-Producing Pituitary Gland Neoplasm

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Hydrolethalus Syndrome 1

Hydrolethalus Syndrome	HLS1
Salonen-Herva-Norio Syndrome	Hls
Hydrolethalus	Hydrolethalus Syndrome, Type 1

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland	Endocrine Active Pituitary Adenoma
Secreting Pituitary Adenoma	Pituitary Adenoma, Functioning

Hyperpituitarism

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma	Growth Hormone-Secreting Pituitary Adenoma
Growth Hormone Producing Adenoma Of The Pituitary	Growth Hormone Secreting Adenoma Of Pituitary

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0036	Octreotide	Agonist	99.64%	Unkown
HY-P0036B	Octreotide pamoate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0024	Veldoreotide	Activator	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1932	Cortistatin-14		99.21%	Unkown
HY-P1203	BIM-23056	Antagonist	99.94%	Unkown
HY-P4452	PRL 2915	Antagonist	99.57%	Unkown
HY-P3618	Cortistatin-29 (reduced)		99.22%	Unkown
HY-P0024A	Veldoreotide TFA	Agonist	98.37%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P1203A	BIM-23056 TFA	Antagonist	/	Unkown
HY-P2150	Cortistatin-29		/	Unkown
HY-123335	L-796,778	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SSTR3	MGD	MGI:98329
Canis familiaris	SSTR3	VGNC	VGNC:46845
Rattus norvegicus	SSTR3	RGD	RGD:620308
Macaca mulatta	SSTR3	VGNC	VGNC:77894
Bos taurus	SSTR3	VGNC	VGNC:35327
Felis catus	SSTR3	VGNC	VGNC:65712

Name
Email *

	Sorry, but the email address you supplied was invalid.