TEAD1 - TEA domain transcription factor 1 Gene

Homo sapiens

Also known as AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1

Gene ID: 7003 | Gene type: protein coding

About TEAD1

Cytogenetic location: 11p15.3 Genomic coordinates (GRCh38): 11:12,674,421-12,944,737 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues, 3 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 17.6), esophagus (RPKM 16.7) and 24 other tissues.

Summary

This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

TEAD1 Products(1)

mRNA	Protein	Name
NM_021961.6	NP_068780.2	transcriptional enhancer factor TEF-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18579750	GOA
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	20123905	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	26045994	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	26045994	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9869635	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	18579750	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20123905	GOA
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	18579750	GOA
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	26045994	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20123905	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25796446	GOA
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	20123905	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TEAD-YAP complex	IDA IDA: Inferred from direct assay	20123905	GOA
part of TEAD-YAP complex	IPI IPI: Inferred from physical interaction	25384421	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD1 Protein Structure

TEA

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

transcriptional enhancer factor TEF-1

TEA domain family member 1 (SV40 transcriptional enhancer factor)

Related Diseases

Diseases

Alias

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Aicardi Syndrome

AIC	Corpus Callosum, Agenesis Of, With Chorioretinal Abnormality
Agenesis Of Corpus Callosum With Chorioretinal Abnormality	Aicardi'S Syndrome
Agenesis Of Corpus Callosum With Infantile Spasms And Ocular Abnormalities	Callosal Agenesis And Ocular Abnormalities
Chorioretinal Anomalies With Acc

Spindle Cell Rhabdomyosarcoma

Neurofibroma

Neurofibromas	Neurofibromatoses
Nerve Sheath Tumors

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal	Rhabdomyosarcoma Embryonal
Botryoid Rhabdomyosarcoma	Erms
Spindle Cell Rhabdomyosarcomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134956	VT104	Inhibitor	99.94%	Unkown
HY-134955	VT103	Inhibitor	99.26%	Unkown
HY-P2244A	YAP-TEAD-IN-1 TFA	Inhibitor	99.75%	Unkown
HY-147208	MSC-4106	Inhibitor	99.82%	Unkown
HY-147088	TEAD-IN-2	Inhibitor	98.93%	Unkown
HY-P2244	YAP-TEAD-IN-1	Inhibitor	/	Unkown
HY-161443	TEAD-IN-9	Inhibitor	/	Unkown
HY-161568	TEAD-IN-10	Inhibitor	/	Unkown
HY-161569	TEAD-IN-11	Inhibitor	/	Unkown
HY-168506	MSC-1254	Inhibitor	/	Unkown
HY-169316	YAP/TAZ inhibitor-4	Inhibitor	/	Unkown
HY-RS14342	TEAD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-168505	MSC-5046	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TEAD1	VGNC	VGNC:47228
Mus musculus	TEAD1	MGD	MGI:101876
Macaca mulatta	TEAD1	VGNC	VGNC:78301
Felis catus	TEAD1	VGNC	VGNC:66053
Bos taurus	TEAD1	VGNC	VGNC:35724
Rattus norvegicus	TEAD1	RGD	RGD:1549742

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