TEAD3 - TEA domain transcription factor 3 Gene

Homo sapiens

Also known as TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3

Gene ID: 7005 | Gene type: protein coding

About TEAD3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,473,597-35,497,079 (from NCBI)

This gene has 3 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 22.4), endometrium (RPKM 21.2) and 23 other tissues.

Summary

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]

TEAD3 Products(2)

mRNA	Protein	Name
NM_001395214.1	NP_001382143.1	transcriptional enhancer factor TEF-5 isoform 2
NM_003214.4	NP_003205.2	transcriptional enhancer factor TEF-5 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18579750	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	23946438	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in asymmetric neuroblast division	IGI IGI: Inferred from genetic interaction	23946438	GOA
involved in hippo signaling	IDA IDA: Inferred from direct assay	18579750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD3 Protein Structure

TEA

0
100
200
300
400
435 a.a.

Protein Preferred Names

Protein Names

transcriptional enhancer factor TEF-5

TEA domain family member 3

Recombinant TEAD3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71626	TEAD3 Protein, Human (His-SUMO)	Q99594 (M112-D435)	≥95%

Related Diseases

Diseases

Alias

Skin Carcinoma In Situ

Carcinoma In Situ Of Skin

Cutaneous Carcinoma In Situ

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134956	VT104	Inhibitor	99.94%	Unkown
HY-147208	MSC-4106	Inhibitor	99.82%	Unkown
HY-161568	TEAD-IN-10	Inhibitor	/	Unkown
HY-161569	TEAD-IN-11	Inhibitor	/	Unkown
HY-RS14344	TEAD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TEAD3	RGD	RGD:1311583
Mus musculus	TEAD3	MGD	MGI:109241
Bos taurus	TEAD3	VGNC	VGNC:35726
Macaca mulatta	TEAD3	VGNC	VGNC:78303
Felis catus	TEAD3	VGNC	VGNC:66055
Canis familiaris	TEAD3	VGNC	VGNC:47230
Others	TEAD3	NCBI

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