KLC3 - kinesin light chain 3 Gene

Homo sapiens

Also known as KLC2; KLCt; KLC2L; KNS2B

Gene ID: 147700 | Gene type: protein coding

About KLC3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,340,750-45,351,519 (from NCBI)

This gene has 7 transcripts (splice variants), 373 orthologues and 5 paralogues. Biased expression in skin (RPKM 20.7), esophagus (RPKM 4.3) and 4 other tissues.

Summary

This gene encodes a member of the Kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two Kinesin heavy chain (KHC) and two Kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating Kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]

KLC3 Products(1)

mRNA	Protein	Name
NM_177417.3	NP_803136.2	kinesin light chain 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLC3 Protein Structure

Rab5-bind

TPR_1

TPR_12

TPR_10

0
100
200
300
400
504 a.a.

Protein Preferred Names

Protein Names

kinesin light chain 3

kinesin light chain 2

KLC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KLC3	Q6P597	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	KLC3	Q6P597	BICDL2	Homo sapiens	A1A5D9	Y2H Array	31515488
Intra	KLC3	Q6P597	BICDL2	Homo sapiens	A1A5D9	Validated Y2H	25416956
Intra	KLC3	Q6P597	BICDL2	Homo sapiens	A1A5D9	Y2H Array	25416956
Intra	KLC3	Q6P597	ZNF572	Homo sapiens	Q7Z3I7	Y2H Array	25416956
Intra	KLC3	Q6P597	ZNF572	Homo sapiens	Q7Z3I7	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
Intra	KLC3	Q6P597	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	25416956
Intra	KLC3	Q6P597	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	KLC3	Q6P597	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	KLC3	Q6P597	MBIP	Homo sapiens	Q9NS73-5	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	QARS1	Homo sapiens	P47897-2	Y2H Array	25416956
Intra	KLC3	Q6P597	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	KLC3	Q6P597	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	KLC3	Q6P597	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	KLC3	Q6P597	SNAP47	Homo sapiens	Q5SQN1	Validated Y2H	25416956
Intra	KLC3	Q6P597	SNAP47	Homo sapiens	Q5SQN1	Y2H Array	25416956
Intra	KLC3	Q6P597	SNAP47	Homo sapiens	Q5SQN1	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	PDE4DIP	Homo sapiens	Q5VU43	Y2H Array	25416956
Intra	KLC3	Q6P597	TSNAX	Homo sapiens	Q99598	Anti Tag CoIP	33961781
Intra	KLC3	Q6P597	TSNAX	Homo sapiens	Q99598	Validated Y2H	25416956
Intra	KLC3	Q6P597	TSNAX	Homo sapiens	Q99598	Y2H Array	25416956
Intra	KLC3	Q6P597	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	KLC3	Q6P597	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	KLC3	Q6P597	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	KLC3	Q6P597	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	KLC3	Q6P597	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	KLC3	Q6P597	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	KLC3	Q6P597	VPS52	Homo sapiens	Q8N1B4	Y2H Array	25416956
Intra	KLC3	Q6P597	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	KLC3	Q6P597	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	KLC3	Q6P597	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	KLC3	Q6P597	BBS5	Homo sapiens	Q8N3I7	Y2H Array	25416956
Intra	KLC3	Q6P597	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
Intra	KLC3	Q6P597	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	KLC3	Q6P597	QARS1	Homo sapiens	P47897	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	KLC3	Q6P597	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	KLC3	Q6P597	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	KLC3	Q6P597	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	KLC3	Q6P597	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	KLC3	Q6P597	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	KLC3	Q6P597	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	33961781
Intra	KLC3	Q6P597	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	KLC3	Q6P597	HSPA2	Homo sapiens	P54652	Y2H Pooling	32814053
Intra	KLC3	Q6P597	HSPA2	Homo sapiens	P54652	Validated Y2H	32814053
Intra	KLC3	Q6P597	HSPA2	Homo sapiens	P54652	Y2H Array	32814053
Intra	KLC3	Q6P597	YWHAG	Homo sapiens	P61981	SLC	36931259
Intra	KLC3	Q6P597	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	KLC3	Q6P597	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	KLC3	Q6P597	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	KLC3	Q6P597	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	KLC3	Q6P597	STX11	Homo sapiens	O75558	Validated Y2H	25416956
Intra	KLC3	Q6P597	STX11	Homo sapiens	O75558	Y2H Array	25416956
Intra	KLC3	Q6P597	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
Intra	KLC3	Q6P597	NDC80	Homo sapiens	O14777	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	KRT15	Homo sapiens	P19012	Validated Y2H	25416956
Intra	KLC3	Q6P597	DTX2	Homo sapiens	Q86UW9	Validated Y2H	25416956
Intra	KLC3	Q6P597	DTX2	Homo sapiens	Q86UW9	Y2H Array	25416956
Intra	KLC3	Q6P597	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
Intra	KLC3	Q6P597	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
Intra	KLC3	Q6P597	CCNH	Homo sapiens	P51946	Y2H Array	31515488
Intra	KLC3	Q6P597	CCNH	Homo sapiens	P51946	Validated Y2H	25416956
Intra	KLC3	Q6P597	CCNH	Homo sapiens	P51946	Y2H Array	25416956
Intra	KLC3	Q6P597	CBY2	Homo sapiens	Q8NA61	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	ABI3	Homo sapiens	Q9P2A4	Y2H Array	25416956
Intra	KLC3	Q6P597	ABI3	Homo sapiens	Q9P2A4	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	25416956
Intra	KLC3	Q6P597	IMP3	Homo sapiens	Q9NV31	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	IMP3	Homo sapiens	Q9NV31	Validated Y2H	25416956
Intra	KLC3	Q6P597	IMP3	Homo sapiens	Q9NV31	Y2H Array	25416956
Intra	KLC3	Q6P597	WAC	Homo sapiens	Q9BTA9	Y2H Prey Pooling	25416956
Intra	KLC3	Q6P597	WAC	Homo sapiens	Q9BTA9	Y2H Array	25416956
Intra	KLC3	Q6P597	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	KLC3	Q6P597	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	KLC3	Q6P597	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	KLC3	Q6P597	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome	SPOAN
Spastic Paraplegia, Optic Atropy, And Neuropathy	Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07328	KLC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KLC3	MGD	MGI:1277971
Macaca mulatta	KLC3	VGNC	VGNC:73870
Canis familiaris	KLC3	VGNC	VGNC:42428
Felis catus	KLC3	VGNC	VGNC:63128
Rattus norvegicus	KLC3	RGD	RGD:621432
Bos taurus	KLC3	VGNC	VGNC:30624

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