NR4A1 - nuclear receptor subfamily 4 group A member 1 Gene

Homo sapiens

Also known as HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77

Gene ID: 3164 | Gene type: protein coding

About NR4A1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,022,832-52,059,503 (from NCBI)

This gene has 22 transcripts (splice variants), 268 orthologues and 2 paralogues. Broad expression in adrenal (RPKM 103.3), ovary (RPKM 73.7) and 19 other tissues.

Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

NR4A1 Products(4)

mRNA	Protein	Name
NM_001202233.2	NP_001189162.1	nuclear receptor subfamily 4 group A member 1 isoform 2
NM_001202234.2	NP_001189163.1	nuclear receptor subfamily 4 group A member 1 isoform 3
NM_002135.5	NP_002126.2	nuclear receptor subfamily 4 group A member 1 isoform 1
NM_173157.3	NP_775180.1	nuclear receptor subfamily 4 group A member 1 isoform 1

NR4A1 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
598 a.a.

Protein Preferred Names

Protein Names

nuclear receptor subfamily 4 group A member 1

ST-59

Related Diseases

Diseases

Alias

Pseudohypoaldosteronism

Pyomyositis

Tropical Pyomyositis	Myositis Tropicans
Myositis Purulenta Tropica	Pm
Suppurative Myositis	Purulent Myositis

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

46,Xy Sex Reversal 2

Dosage-Sensitive Sex Reversal	Dss
SRXY2	46,Xy Sex Reversal, Dax1-Related
46xy Sex Reversal 2, Dosage-Sensitive	46,Xy Sex Reversal Dax1-Related

Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h	CSNB1H
Congenital Stationary Night Blindness Type 1h	Night Blindness, Congenital Stationary, 1h

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Rhabdomyosarcoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1624	Teduglutide	Activator	99.94%	Unkown
HY-P1624A	Teduglutide TFA	Activator	/	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2148	Cytosporone B	Agonist	98.63%	Unkown
HY-112055	DIM-C-pPhOH		99.05%	Unkown
HY-112056	DIM-C-pPhCO2Me	Antagonist	99.47%	Unkown
HY-RS09550	NR4A1 Human Pre-designed siRNA Set A		/	Unkown
HY-160498	Amoitone B	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NR4A1	VGNC	VGNC:32245
Canis familiaris	NR4A1	VGNC	VGNC:43954
Mus musculus	NR4A1	MGD	MGI:1352454
Rattus norvegicus	NR4A1	RGD	RGD:620029
Felis catus	NR4A1	VGNC	VGNC:68554
Macaca mulatta	NR4A1	VGNC	VGNC:75517

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