NR4A1 - nuclear receptor subfamily 4 group A member 1 Gene

Homo sapiens

Also known as HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77

Gene ID: 3164 | Gene type: protein coding

About NR4A1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,022,832-52,059,503 (from NCBI)

This gene has 22 transcripts (splice variants), 268 orthologues and 2 paralogues. Broad expression in adrenal (RPKM 103.3), ovary (RPKM 73.7) and 19 other tissues.

Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces Apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

NR4A1 Products(4)

mRNA	Protein	Name
NM_001202233.2	NP_001189162.1	nuclear receptor subfamily 4 group A member 1 isoform 2
NM_001202234.2	NP_001189163.1	nuclear receptor subfamily 4 group A member 1 isoform 3
NM_002135.5	NP_002126.2	nuclear receptor subfamily 4 group A member 1 isoform 1
NM_173157.3	NP_775180.1	nuclear receptor subfamily 4 group A member 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8121493	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17139261	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	18059339	GOA
involved in cellular response to fibroblast growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18059339	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18059339	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22427340	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9315652	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	18690216	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8121493	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR4A1 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
598 a.a.

Protein Preferred Names

Protein Names

nuclear receptor subfamily 4 group A member 1

ST-59

NR4A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NR4A1	P22736	KRTAP10-5	Homo sapiens	P60370	Y2H Prey Pooling	25416956
Intra	NR4A1	P22736	PGBD1	Homo sapiens	Q96JS3	Y2H Array	25416956
Intra	NR4A1	P22736	PGBD1	Homo sapiens	Q96JS3	Y2H Prey Pooling	25416956
Cross	NR4A1	P22736	E2	Human papillomavirus	P03120	SLC	22761572
Intra	NR4A1	P22736	LONRF1	Homo sapiens	Q17RB8	Y2H Prey Pooling	25416956
Intra	NR4A1	P22736	IFI27	Homo sapiens	P40305-2	Anti Bait CoIP	22427340
Intra	NR4A1	P22736	IFI27	Homo sapiens	P40305-2	Y2H	22427340
Intra	NR4A1	P22736	IFI27	Homo sapiens	P40305-2	FRET	22427340
Intra	NR4A1	P22736	IFI27	Homo sapiens	P40305-2	IF	22427340
Intra	NR4A1	P22736	MATR3	Homo sapiens	P43243	Display Tech	20195357
Intra	NR4A1	P22736	TUBB4A	Homo sapiens	P04350	Display Tech	20195357
Intra	NR4A1	P22736	XPO1	Homo sapiens	O14980	Anti Bait CoIP	22427340
Intra	NR4A1	P22736	TP53	Homo sapiens	P04637	Pull Down	17139261
Intra	NR4A1	P22736	TP53	Homo sapiens	P04637	Anti Tag CoIP	17139261
Intra	NR4A1	P22736	GK	Homo sapiens	P32189	Y2H	21988832
Intra	NR4A1	P22736	GK	Homo sapiens	P32189	Anti Tag CoIP	21988832
Intra	NR4A1	P22736	STAT3	Homo sapiens	P40763	Anti Tag CoIP	21988832
Intra	NR4A1	P22736	CDKN2D	Homo sapiens	P55273	Validated Y2H	25416956
Intra	NR4A1	P22736	CDKN2D	Homo sapiens	P55273	Y2H Prey Pooling	25416956
Intra	NR4A1	P22736	CDKN2D	Homo sapiens	P55273	Y2H Array	31515488
Intra	NR4A1	P22736	BCL2	Homo sapiens	P10415	CD	18835031
Intra	NR4A1	P22736	PRMT1	Homo sapiens	Q99873	CH-IP	19095693
Intra	NR4A1	P22736	PRMT1	Homo sapiens	Q99873	Anti Bait CoIP	19095693
Intra	NR4A1	P22736	PRMT1	Homo sapiens	Q99873	Anti Tag CoIP	19095693

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pseudohypoaldosteronism

Pyomyositis

Tropical Pyomyositis	Myositis Tropicans
Myositis Purulenta Tropica	Pm
Suppurative Myositis	Purulent Myositis

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

46,Xy Sex Reversal 2

Dosage-Sensitive Sex Reversal	Dss
SRXY2	46,Xy Sex Reversal, Dax1-Related
46xy Sex Reversal 2, Dosage-Sensitive	46,Xy Sex Reversal Dax1-Related

Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h	CSNB1H
Congenital Stationary Night Blindness Type 1h	Night Blindness, Congenital Stationary, 1h

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Rhabdomyosarcoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1624	Teduglutide	Activator	99.94%	Unkown
HY-P1624A	Teduglutide TFA	Activator	/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2148	Cytosporone B	Agonist	98.63%	Unkown
HY-112055	DIM-C-pPhOH		99.05%	Unkown
HY-112056	DIM-C-pPhCO2Me	Antagonist	99.47%	Unkown
HY-RS09550	NR4A1 Human Pre-designed siRNA Set A		/	Unkown
HY-159779	NR-V04	Degrader	/	Unkown
HY-160498	Amoitone B	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NR4A1	VGNC	VGNC:32245
Canis familiaris	NR4A1	VGNC	VGNC:43954
Mus musculus	NR4A1	MGD	MGI:1352454
Rattus norvegicus	NR4A1	RGD	RGD:620029
Felis catus	NR4A1	VGNC	VGNC:68554
Macaca mulatta	NR4A1	VGNC	VGNC:75517

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