1. Gene
  2. TCL1A - TCL1 family AKT coactivator A Gene

TCL1A - TCL1 family AKT coactivator A Gene

Homo sapiens

Also known as TCL1

Gene ID: 8115 | Gene type: protein coding

About TCL1A

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:95,709,947-95,714,125 (from NCBI)

This gene has 9 transcripts (splice variants), 106 orthologues, 2 paralogues and is associated with 45 phenotypes. Biased expression in lymph node (RPKM 72.1), spleen (RPKM 19.8) and 2 other tissues.

Summary

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase Akt (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

TCL1A Products(2)

mRNA Protein Name
NM_001098725.2 NP_001092195.1 T-cell leukemia/lymphoma protein 1A
NM_021966.3 NP_068801.1 T-cell leukemia/lymphoma protein 1A
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IDA
IDA: Inferred from direct assay
10983986 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
10983986 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
10983986 GOA
enables protein serine/threonine kinase activator activity IMP
IMP: Inferred from mutant phenotype
10983986 GOA
Biological Process GO Annotation Evidence Reference Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10983986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCL1A Protein Structure

TCL1_MTCP1

TCL1_MTCP1: TCL1/MTCP1 family (1 - 112)

  • 0
  • 100
  • 114 a.a.
Protein Preferred Names Protein Names

T-cell leukemia/lymphoma protein 1A

T cell leukemia/lymphoma 1A

TCL1A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TCL1A P56279 TP53BP2 Homo sapiens Q13625-3 25416956
Intra
TCL1A P56279 TP53BP2 Homo sapiens Q13625-3 25416956
Intra
TCL1A P56279 AKT1 Homo sapiens B0LPE5 25416956
Intra
TCL1A P56279 AKT1 Homo sapiens B0LPE5 25416956
Intra
TCL1A P56279 AKT1 Homo sapiens B0LPE5 25416956
Intra
TCL1A P56279 CADPS Homo sapiens A2RRN7 32296183
Intra
TCL1A P56279 CADPS Homo sapiens A2RRN7 25416956
Intra
TCL1A P56279 CADPS Homo sapiens A2RRN7 32296183
Intra
TCL1A P56279 CADPS Homo sapiens A2RRN7 25416956
Intra
TCL1A P56279 NFKBID Homo sapiens Q8NI38 32296183
Intra
TCL1A P56279 NFKBID Homo sapiens Q8NI38 32296183
Intra
TCL1A P56279 NFKBID Homo sapiens Q8NI38 32296183
Intra
TCL1A P56279 REL Homo sapiens Q04864-2 32296183
Intra
TCL1A P56279 REL Homo sapiens Q04864-2 32296183
Intra
TCL1A P56279 REL Homo sapiens Q04864-2 32296183
Intra
TCL1A P56279 CCDC13 Homo sapiens Q8IYE1 32296183
Intra
TCL1A P56279 CCDC13 Homo sapiens Q8IYE1 32296183
Intra
TCL1A P56279 CCDC13 Homo sapiens Q8IYE1 32296183
Intra
TCL1A P56279 PPP1R13B Homo sapiens Q96KQ4 32296183
Intra
TCL1A P56279 PPP1R13B Homo sapiens Q96KQ4 32296183
Intra
TCL1A P56279 PPP1R13B Homo sapiens Q96KQ4 32296183
Intra
TCL1A P56279 TNKS Homo sapiens O95271 32296183
Intra
TCL1A P56279 TNKS Homo sapiens O95271 32296183
Intra
TCL1A P56279 TEPSIN Homo sapiens Q96N21 32296183
Intra
TCL1A P56279 TEPSIN Homo sapiens Q96N21 32296183
Intra
TCL1A P56279 TEPSIN Homo sapiens Q96N21 32296183
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257-2 32296183
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257-2 32296183
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257-2 32296183
Intra
TCL1A P56279 TTC33 Homo sapiens Q6PID6 32296183
Intra
TCL1A P56279 TTC33 Homo sapiens Q6PID6 25416956
Intra
TCL1A P56279 NFKBIA Homo sapiens P25963 32296183
Intra
TCL1A P56279 NFKBIA Homo sapiens P25963 32296183
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 32296183
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 25416956
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 32296183
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 32296183
Intra
TCL1A P56279 LSM3 Homo sapiens P62310 25416956
Intra
TCL1A P56279 TRAF2 Homo sapiens Q12933 32296183
Intra
TCL1A P56279 TRAF2 Homo sapiens Q12933 32296183
Intra
TCL1A P56279 TRAF2 Homo sapiens Q12933 32296183
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 32296183
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 25416956
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 27107012
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 32296183
Intra
TCL1A P56279 TRAF1 Homo sapiens Q13077 32296183
Intra
TCL1A P56279 TXLNA Homo sapiens P40222 32296183
Intra
TCL1A P56279 TXLNA Homo sapiens P40222 25416956
Intra
TCL1A P56279 TXLNA Homo sapiens P40222 32296183
Intra
TCL1A P56279 TXLNA Homo sapiens P40222 33961781
Intra
TCL1A P56279 TAX1BP1 Homo sapiens Q86VP1 32296183
Intra
TCL1A P56279 TAX1BP1 Homo sapiens Q86VP1 32296183
Intra
TCL1A P56279 TAX1BP1 Homo sapiens Q86VP1 32296183
Intra
TCL1A P56279 TCF4 Homo sapiens P15884 25416956
Intra
TCL1A P56279 TCF4 Homo sapiens P15884 25416956
Intra
TCL1A P56279 TXLNB Homo sapiens Q8N3L3 25416956
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 27107012
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 32296183
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 25416956
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 32296183
Intra
TCL1A P56279 GOLGA2 Homo sapiens Q08379 32296183
Intra
TCL1A P56279 INCA1 Homo sapiens Q0VD86 32296183
Intra
TCL1A P56279 INCA1 Homo sapiens Q0VD86 32296183
Intra
TCL1A P56279 INCA1 Homo sapiens Q0VD86 32296183
Intra
TCL1A P56279 WDR47 Homo sapiens O94967 25416956
Intra
TCL1A P56279 WDR47 Homo sapiens O94967 25416956
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 32296183
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 25416956
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 32296183
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 33961781
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 32296183
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 31515488
Intra
TCL1A P56279 CALCOCO2 Homo sapiens Q13137 16189514
Intra
TCL1A P56279 PRTFDC1 Homo sapiens Q9NRG1 25416956
Intra
TCL1A P56279 PRTFDC1 Homo sapiens Q9NRG1 32296183
Intra
TCL1A P56279 PRTFDC1 Homo sapiens Q9NRG1 32296183
Intra
TCL1A P56279 PRTFDC1 Homo sapiens Q9NRG1 32296183
Intra
TCL1A P56279 LNX1 Homo sapiens Q8TBB1 32296183
Intra
TCL1A P56279 LNX1 Homo sapiens Q8TBB1 32296183
Intra
TCL1A P56279 LNX1 Homo sapiens Q8TBB1 32296183
Intra
TCL1A P56279 NIF3L1 Homo sapiens Q9GZT8 32296183
Intra
TCL1A P56279 NIF3L1 Homo sapiens Q9GZT8 32296183
Intra
TCL1A P56279 NIF3L1 Homo sapiens Q9GZT8 32296183
Intra
TCL1A P56279 NTAQ1 Homo sapiens Q96HA8 32296183
Intra
TCL1A P56279 DDIT4L Homo sapiens Q96D03 32296183
Intra
TCL1A P56279 DDIT4L Homo sapiens Q96D03 32296183
Intra
TCL1A P56279 DDIT4L Homo sapiens Q96D03 32296183
Intra
TCL1A P56279 CEP55 Homo sapiens Q53EZ4 25416956
Intra
TCL1A P56279 CEP55 Homo sapiens Q53EZ4
Y2H
27107012
Intra
TCL1A P56279 CEP55 Homo sapiens Q53EZ4 25416956
Intra
TCL1A P56279 CEP55 Homo sapiens Q53EZ4 27107012
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 31515488
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 25416956
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 25416956
Intra
TCL1A P56279 FLACC1 Homo sapiens Q96Q35 25416956
Intra
TCL1A P56279 FLACC1 Homo sapiens Q96Q35 25416956
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257 25416956
Intra
TCL1A P56279 CARD9 Homo sapiens Q9H257 25416956
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 33961781
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 32296183
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 32296183
Intra
TCL1A P56279 DNMT3A Homo sapiens Q9Y6K1 32296183
Intra
TCL1A P56279 TRMT61A Homo sapiens Q96FX7 32296183
Intra
TCL1A P56279 TRMT61A Homo sapiens Q96FX7 32296183
Intra
TCL1A P56279 TRMT61A Homo sapiens Q96FX7 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TCL1A Proteins

Cat. No. Product Name Accession Purity
HY-P74530 TCL1A Protein, Human (His) P56279 (A2-D114) ≥95%

TCL1A Antibodies

Cat. No. Product Name Application Reactivity
HY-P81959 T Cell Leukemia/Lymphoma Protein 1A Antibody (YA1704) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Precursor T-Cell Acute Lymphoblastic Leukemia

T-All

Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma

Precursor T-Cell Acute Lymphocytic Leukemia

Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Adult T-Cell Lymphoma/Leukemia

Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos

Prolymphocytic Leukemia

Pll

Prolymphocytic Leukaemia

Leukemia Prolymphocytic

Leukemia, Prolymphocytic

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

T-Cell Prolymphocytic Leukemia

T Cell Prolymphocytic Leukemia

Prolymphocytic Leukemia, T-Cell Type

T-Pll

T-Cell Chronic Lymphocytic Leukemia

Lymphocytic Leukemia T-Cell Chronic

Doid:0081042

Leukemia, T-Cell, Chronic

Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission

Peripheral T-Cell Lymphoma

Lymphoma T-Cell Peripheral

Lymphoma Aids Related

Primary Effusion Lymphoma

Lymphoma, Aids-Related

Aids-Related Lymphoma

Pel

Aids Related Lymphoma

Body Cavity-Based Lymphoma

Lymphoma Aids-Related

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Seminoma

Seminoma, Pure

Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064

Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Richter'S Syndrome

Richter Syndrome

Richter Transformation

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Follicular Lymphoma

Lymphoma, Follicular

Lymphoma Follicular

Brill-Symmers' Disease

Large Cell Follicular Non-Hodgkin Lymphoma

Diffuse Follicle Centre Lymphoma

Diffuse Follicular Lymphoma Nos

Follicular Nodular Non-Hodgkin Lymphoma, Unspecified

Follicular Large Cell Cleaved Or Noncleaved Lymphoma

Large Cell Follicular Noncleaved Lymphoma

Follicular Lymphoma With Or Without Diffuse Areas

Histiocytic Follicular Lymphoma

Histiocytic Nodular Lymphoma

Histiocytic Nodular Malignant Lymphoma

Large Cell Follicular Lymphoma

Large Cell Noncleaved Follicular Lymphoma

Large Cell Noncleaved Follicular Malignant Lymphoma

Nodular Reticulum Cell Sarcoma

Noncleaved Follicular Lymphoma

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus TCL1A MGD MGI:1097166
Rattus norvegicus TCL1A RGD RGD:1594686
Bos taurus TCL1A VGNC VGNC:99734
Others TCL1A NCBI