TRIM29 - tripartite motif containing 29 Gene

Homo sapiens

Also known as ATDC

Gene ID: 23650 | Gene type: protein coding

About TRIM29

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:120,111,286-120,138,113 (from NCBI)

This gene has 21 transcripts (splice variants), 118 orthologues and 80 paralogues. Biased expression in esophagus (RPKM 274.4), skin (RPKM 264.0) and 4 other tissues.

Summary

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]

TRIM29 Products(2)

mRNA	Protein	Name
NM_001330382.2	NP_001317311.1	tripartite motif-containing protein 29 isoform 2
NM_012101.4	NP_036233.2	tripartite motif-containing protein 29 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM29 Protein Structure

zf-B_box

0
100
200
300
400
500
588 a.a.

Protein Preferred Names

Protein Names

tripartite motif-containing protein 29

ataxia-telangiectasia group D-associated protein

TRIM29 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRIM29	Q14134	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	TRIM29	Q14134	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	TRIM29	Q14134	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	TRIM29	Q14134	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	TRIM29	Q14134	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	TRIM29	Q14134	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	TRIM29	Q14134	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	TRIM29	Q14134	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	TRIM29	Q14134	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	TRIM29	Q14134	ANKS1A	Homo sapiens	Q49AR9	Y2H Array	32296183
Intra	TRIM29	Q14134	ANKS1A	Homo sapiens	Q49AR9	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	TRIM29	Q14134	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	TRIM29	Q14134	ACTN3	Homo sapiens	Q08043	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	ACTN3	Homo sapiens	Q08043	Y2H Array	32296183
Intra	TRIM29	Q14134	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	TRIM29	Q14134	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	TRIM29	Q14134	GOLGA2	Homo sapiens	Q08379	Y2H	21516116
Intra	TRIM29	Q14134	KRT5	Homo sapiens	P13647	Anti Bait CoIP	37671092
Intra	TRIM29	Q14134	TRIM29	Homo sapiens	Q14134	Y2H Array	32296183
Intra	TRIM29	Q14134	CEP70	Homo sapiens	Q8NHQ1	Y2H Pooling	16189514
Intra	TRIM29	Q14134	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	25416956
Intra	TRIM29	Q14134	TRIM29	Homo sapiens	Q14134	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	32296183
Intra	TRIM29	Q14134	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	TRIM29	Q14134	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	32296183
Intra	TRIM29	Q14134	TRIM29	Homo sapiens	Q14134	Y2H Pooling	16189514
Intra	TRIM29	Q14134	TRIM29	Homo sapiens	Q14134	Y2H Array	20211142
Intra	TRIM29	Q14134	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Prey Pooling	32296183
Intra	TRIM29	Q14134	TRIM29	Homo sapiens	Q14134	Validated Y2H	32296183
Intra	TRIM29	Q14134	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	25416956
Intra	TRIM29	Q14134	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	19249679
Intra	TRIM29	Q14134	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	TRIM29	Q14134	TRIM23	Homo sapiens	P36406	Y2H Array	25416956
Intra	TRIM29	Q14134	DVL2	Homo sapiens	O14641	Anti Bait CoIP	19249679
Intra	TRIM29	Q14134	DVL2	Homo sapiens	O14641	IF	19249679
Intra	TRIM29	Q14134	LZTS2	Homo sapiens	Q9BRK4	Y2H Pooling	16189514
Intra	TRIM29	Q14134	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	TRIM29	Q14134	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	TRIM29	Q14134	TRIP6	Homo sapiens	Q15654	Y2H Array	25416956
Intra	TRIM29	Q14134	TRIP6	Homo sapiens	Q15654	Validated Y2H	25416956
Intra	TRIM29	Q14134	GCC1	Homo sapiens	Q96CN9	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128481	SB24011	Activator	/	Unkown
HY-RS15034	TRIM29 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIM29	VGNC	VGNC:36325
Mus musculus	TRIM29	MGD	MGI:1919419
Felis catus	TRIM29	VGNC	VGNC:66532
Rattus norvegicus	TRIM29	RGD	RGD:1307858
Macaca mulatta	TRIM29	VGNC	VGNC:79069
Canis familiaris	TRIM29	VGNC	VGNC:47812

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