SPSB2 - splA/ryanodine receptor domain and SOCS box containing 2 Gene

Homo sapiens

Also known as SSB2; GRCC9

Gene ID: 84727 | Gene type: protein coding

About SPSB2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,870,935-6,873,303 (from NCBI)

This gene has 5 transcripts (splice variants), 148 orthologues and 4 paralogues. Broad expression in brain (RPKM 50.3), appendix (RPKM 44.2) and 19 other tissues.

Summary

This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SPSB2 Products(3)

mRNA	Protein	Name
NM_001146316.2	NP_001139788.1	SPRY domain-containing SOCS box protein 2
NM_001319670.2	NP_001306599.1	SPRY domain-containing SOCS box protein 2
NM_032641.4	NP_116030.1	SPRY domain-containing SOCS box protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15601820	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IPI IPI: Inferred from physical interaction	21199876	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	21199876	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21199876	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	21199876	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPSB2 Protein Structure

SPRY

SOCS_box

0
100
200
263 a.a.

Protein Preferred Names

Protein Names

SPRY domain-containing SOCS box protein 2

SPRY domain-containing SOCS box protein SSB-2

Related Diseases

Diseases

Alias

Congenital Muscular Dystrophy-Dystroglycanopathy A7

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A7	Mddga7
Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease Ispd-Related	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A7

Acute Contagious Conjunctivitis

Pink Eye	Contagious Opthalmia
Pinkeye	Conjunctivitis
Keratoconjunctivitis Due To Mycoplasma Conjunctivae

Acute Conjunctivitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13727	SPSB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPSB2	VGNC	VGNC:50141
Rattus norvegicus	SPSB2	RGD	RGD:1310854
Macaca mulatta	SPSB2	VGNC	VGNC:100107
Felis catus	SPSB2	VGNC	VGNC:65655
Mus musculus	SPSB2	MGD	MGI:1315199
Canis familiaris	SPSB2	VGNC	VGNC:49871

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