2. Gene
  3. CDS2 - CDP-diacylglycerol synthase 2 Gene

CDS2 - CDP-diacylglycerol synthase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8760 | Gene type: protein coding

About CDS2

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:5,127,008-5,197,887 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 21.0), heart (RPKM 9.4) and 24 other tissues.

Summary

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an Enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This Enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this Enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

CDS2 Products(1)

mRNA Protein Name
NM_003818.4 NP_003809.1 phosphatidate cytidylyltransferase 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidate cytidylyltransferase activity IDA
IDA: Inferred from direct assay
25375833 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CDP-diacylglycerol biosynthetic process IDA
IDA: Inferred from direct assay
25375833 GOA
involved in lipid droplet formation IMP
IMP: Inferred from mutant phenotype
26946540 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
25375833 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDS2 Protein Structure

CTP_transf_1

CTP_transf_1: Cytidylyltransferase family (70 - 400)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

phosphatidate cytidylyltransferase 2

CDP-DAG synthase 2

CDS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CDS2 O95674 IL10RA Homo sapiens Q13651
Y2H Prey Pooling
32296183
Intra CDS2 O95674 IL10RA Homo sapiens Q13651
Validated Y2H
32296183
Intra CDS2 O95674 IL10RA Homo sapiens Q13651
Y2H Array
32296183
Intra CDS2 O95674 JSRP1 Homo sapiens Q96MG2
Validated Y2H
32296183
Intra CDS2 O95674 JSRP1 Homo sapiens Q96MG2
Y2H Array
32296183
Intra CDS2 O95674 JSRP1 Homo sapiens Q96MG2
Y2H Prey Pooling
32296183
Intra CDS2 O95674 HIBADH Homo sapiens P31937
Y2H Array
32296183
Intra CDS2 O95674 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
Intra CDS2 O95674 HIBADH Homo sapiens P31937
Validated Y2H
32296183
Intra CDS2 O95674 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra CDS2 O95674 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra CDS2 O95674 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra CDS2 O95674 MR1 Homo sapiens Q95460-2
Y2H Prey Pooling
32296183
Intra CDS2 O95674 MR1 Homo sapiens Q95460-2
Validated Y2H
32296183
Intra CDS2 O95674 MR1 Homo sapiens Q95460-2
Y2H Array
32296183
Intra CDS2 O95674 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra CDS2 O95674 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra CDS2 O95674 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra CDS2 O95674 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra CDS2 O95674 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra CDS2 O95674 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra CDS2 O95674 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra CDS2 O95674 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra CDS2 O95674 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra CDS2 O95674 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra CDS2 O95674 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra CDS2 O95674 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra CDS2 O95674 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra CDS2 O95674 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra CDS2 O95674 RNF122 Homo sapiens Q9H9V4
Y2H Prey Pooling
32296183
Intra CDS2 O95674 RNF122 Homo sapiens Q9H9V4
Validated Y2H
32296183
Intra CDS2 O95674 RNF122 Homo sapiens Q9H9V4
Y2H Array
32296183
Intra CDS2 O95674 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra CDS2 O95674 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra CDS2 O95674 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra CDS2 O95674 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra CDS2 O95674 TSPAN12 Homo sapiens O95859
Validated Y2H
32296183
Intra CDS2 O95674 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra CDS2 O95674 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra CDS2 O95674 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra CDS2 O95674 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra CDS2 O95674 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra CDS2 O95674 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra CDS2 O95674 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra CDS2 O95674 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra CDS2 O95674 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra CDS2 O95674 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra CDS2 O95674 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra CDS2 O95674 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra CDS2 O95674 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra CDS2 O95674 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra CDS2 O95674 GSN Homo sapiens P06396
Y2H Array
32814053
Intra CDS2 O95674 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra CDS2 O95674 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra CDS2 O95674 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra CDS2 O95674 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra CDS2 O95674 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra CDS2 O95674 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra CDS2 O95674 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra CDS2 O95674 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra CDS2 O95674 HTT Homo sapiens P42858
Y2H Array
32814053
Intra CDS2 O95674 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra CDS2 O95674 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra CDS2 O95674 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra CDS2 O95674 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra CDS2 O95674 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra CDS2 O95674 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra CDS2 O95674 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra CDS2 O95674 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra CDS2 O95674 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra CDS2 O95674 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra CDS2 O95674 MYG1 Homo sapiens Q9HB07
Y2H Prey Pooling
32296183
Intra CDS2 O95674 MYG1 Homo sapiens Q9HB07
Y2H Array
32296183
Intra CDS2 O95674 MYG1 Homo sapiens Q9HB07
Validated Y2H
32296183
Intra CDS2 O95674 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra CDS2 O95674 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra CDS2 O95674 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra CDS2 O95674 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra CDS2 O95674 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra CDS2 O95674 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02425 CDS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-106828 E2-CDS / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CDS2 VGNC VGNC:70995
Bos taurus CDS2 VGNC VGNC:27156
Mus musculus CDS2 MGD MGI:1332236
Rattus norvegicus CDS2 RGD RGD:621186
Canis familiaris CDS2 VGNC VGNC:39081
Felis catus CDS2 VGNC VGNC:60720