EBAG9 - estrogen receptor binding site associated antigen 9 Gene

Homo sapiens

Also known as EB9; PDAF

Gene ID: 9166 | Gene type: protein coding

About EBAG9

Cytogenetic location: 8q23.2 Genomic coordinates (GRCh38): 8:109,539,702-109,565,996 (from NCBI)

This gene has 13 transcripts (splice variants) and 227 orthologues. Ubiquitous expression in thyroid (RPKM 14.2), adrenal (RPKM 7.5) and 25 other tissues.

Summary

This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by Estrogen Receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. [provided by RefSeq, Jul 2013]

EBAG9 Products(3)

mRNA	Protein	Name
NM_001278938.2	NP_001265867.1	receptor-binding cancer antigen expressed on SiSo cells
NM_004215.5	NP_004206.1	receptor-binding cancer antigen expressed on SiSo cells
NM_198120.3	NP_936056.1	receptor-binding cancer antigen expressed on SiSo cells

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

receptor-binding cancer antigen expressed on SiSo cells

cancer-associated surface antigen RCAS1

EBAG9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EBAG9	O00559	SLC35B4	Homo sapiens	Q969S0	Validated Y2H	32296183
Intra	EBAG9	O00559	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	EBAG9	O00559	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	EBAG9	O00559	CFHR5	Homo sapiens	Q9BXR6	Validated Y2H	32296183
Intra	EBAG9	O00559	VAPB	Homo sapiens	O95292	Validated Y2H	32296183
Intra	EBAG9	O00559	STX2	Homo sapiens	P32856-2	Validated Y2H	32296183
Intra	EBAG9	O00559	NRAC	Homo sapiens	Q8N912	Validated Y2H	32296183
Intra	EBAG9	O00559	SLC35A4	Homo sapiens	Q96G79	Validated Y2H	32296183
Intra	EBAG9	O00559	TMEM107	Homo sapiens	Q6UX40	Validated Y2H	32296183
Intra	EBAG9	O00559	SLC35A1	Homo sapiens	P78382	Validated Y2H	32296183
Intra	EBAG9	O00559	OR10AG1	Homo sapiens	Q8NH19	Validated Y2H	32296183
Intra	EBAG9	O00559	STX3	Homo sapiens	Q13277	Validated Y2H	32296183
Intra	EBAG9	O00559	REEP6	Homo sapiens	Q96HR9-2	Validated Y2H	32296183
Intra	EBAG9	O00559	TPRG1	Homo sapiens	Q6ZUI0	Validated Y2H	32296183
Intra	EBAG9	O00559	CLEC4G	Homo sapiens	Q6UXB4	Validated Y2H	32296183
Intra	EBAG9	O00559	PRAF2	Homo sapiens	O60831	Validated Y2H	32296183
Intra	EBAG9	O00559	ACSL5	Homo sapiens	Q9ULC5	Validated Y2H	32296183
Intra	EBAG9	O00559	APOL2	Homo sapiens	Q9BQE5	Validated Y2H	32296183
Intra	EBAG9	O00559	CLN6	Homo sapiens	Q9NWW5	Validated Y2H	32296183
Intra	EBAG9	O00559	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	EBAG9	O00559	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	EBAG9	O00559	CIAO2A	Homo sapiens	Q9H5X1	Validated Y2H	32296183
Intra	EBAG9	O00559	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
Intra	EBAG9	O00559	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	EBAG9	O00559	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EBAG9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76881	EBAG9 Protein, Human (His)	O00559-1 (R28-S213)	≥95%

Related Diseases

Diseases

Alias

Cervical Adenocarcinoma

Adenocarcinoma Cervix Uteri	Adenocarcinoma Of Cervix
Adenocarcinoma Of The Uterine Cervix	Adenocarcinoma Of The Cervix Uteri

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Gallbladder Cancer

Gallbladder Carcinoma	Gallbladder Neoplasm
Malignant Neoplasm Of Gallbladder	Malignant Tumour Of Gallbladder
Gallbladder Ca	Localized Malignant Gallbladder Neoplasm
Malignant Tumor Of The Gallbladder	Tumor Of The Gallbladder
Cancer Of The Gallbladder	Carcinoma Gallbladder
Carcinoma Of Gallbladder	Gallbladder Neoplasms
Malignant Neoplasm Of Gallbladder Localized	Cancer Of Gallbladder
Primary Malignant Neoplasm Of Gallbladder

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Large Intestine Adenocarcinoma

Adenocarcinoma Of Large Intestine

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Adenitis	Chronic Adenitis
Acute Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04123	EBAG9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EBAG9	RGD	RGD:1307293
Felis catus	EBAG9	VGNC	VGNC:97406
Mus musculus	EBAG9	MGD	MGI:1859920
Bos taurus	EBAG9	VGNC	VGNC:97262
Canis familiaris	EBAG9	VGNC	VGNC:40174
Macaca mulatta	EBAG9	VGNC	VGNC:72029
Others	EBAG9	NCBI

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