MAP3K13 - mitogen-activated protein kinase kinase kinase 13 Gene

Homo sapiens

Also known as LZK; MLK; MEKK13

Gene ID: 9175 | Gene type: protein coding

About MAP3K13

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,282,961-185,489,094 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues, 23 paralogues and is associated with 94 phenotypes. Ubiquitous expression in adrenal (RPKM 3.8), kidney (RPKM 3.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

MAP3K13 Products(3)

mRNA	Protein	Name
NM_001242314.2	NP_001229243.1	mitogen-activated protein kinase kinase kinase 13 isoform 1
NM_001242317.2	NP_001229246.1	mitogen-activated protein kinase kinase kinase 13 isoform 2
NM_004721.5	NP_004712.1	mitogen-activated protein kinase kinase kinase 13 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables IkappaB kinase complex binding	IDA IDA: Inferred from direct assay	12492477	GOA
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11726277	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	12492477	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11163770	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11726277	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11163770	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9353328	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	9353328	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	12492477	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	9353328	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9353328	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	11726277	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	9353328	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K13 Protein Structure

Pkinase_Tyr

0
200
400
600
800
966 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase 13

leucine zipper-bearing kinase

MAP3K13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP3K13	O43283	GLO1	Homo sapiens	Q04760	Y2H Array	21988832
Intra	MAP3K13	O43283	DYNC1H1	Homo sapiens	Q14204	Pull Down	32707033
Intra	MAP3K13	O43283	CDC5L	Homo sapiens	Q99459	Pull Down	32707033
Intra	MAP3K13	O43283	KLHL20	Homo sapiens	Q9Y2M5	Anti Tag CoIP	33961781
Intra	MAP3K13	O43283	FAM120A	Homo sapiens	Q9NZB2	Pull Down	32707033
Intra	MAP3K13	O43283	HADHA	Homo sapiens	P40939	Pull Down	32707033
Intra	MAP3K13	O43283	KRR1	Homo sapiens	Q13601	Pull Down	32707033
Intra	MAP3K13	O43283	INPPL1	Homo sapiens	O15357	Anti Tag CoIP	33961781
Intra	MAP3K13	O43283	CDC42	Homo sapiens	P60953	Pull Down	32707033
Intra	MAP3K13	O43283	INA	Homo sapiens	Q16352	Pull Down	32707033
Intra	MAP3K13	O43283	STAT3	Homo sapiens	P40763	Y2H Array	21988832
Intra	MAP3K13	O43283	CYFIP2	Homo sapiens	Q96F07	Pull Down	32707033
Intra	MAP3K13	O43283	MAP3K13	Homo sapiens	O43283	Anti Tag CoIP	11163770
Intra	MAP3K13	O43283	CSNK2A1	Homo sapiens	P68400	Pull Down	32707033
Intra	MAP3K13	O43283	H2AC20	Homo sapiens	Q16777	Anti Tag CoIP	33961781
Intra	MAP3K13	O43283	PRDX3	Homo sapiens	P30048	Pull Down	32707033
Intra	MAP3K13	O43283	SMC4	Homo sapiens	Q9NTJ3	Pull Down	32707033
Intra	MAP3K13	O43283	FLNC	Homo sapiens	Q14315	Pull Down	32707033
Intra	MAP3K13	O43283	COLGALT1	Homo sapiens	Q8NBJ5	Pull Down	32707033
Intra	MAP3K13	O43283	RAD50	Homo sapiens	Q92878	Pull Down	32707033
Intra	MAP3K13	O43283	MRPS35	Homo sapiens	P82673	Pull Down	32707033
Intra	MAP3K13	O43283	P4HA1	Homo sapiens	P13674	Pull Down	32707033

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Carotid Body Cancer

Cancer Of Carotid Body	Malignant Carotid Body Paraganglioma
Malignant Carotid Body Tumor	Malignant Neoplasm Of Carotid Body

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08050	MAP3K13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAP3K13	VGNC	VGNC:31191
Felis catus	MAP3K13	VGNC	VGNC:68158
Rattus norvegicus	MAP3K13	RGD	RGD:1561227
Mus musculus	MAP3K13	MGD	MGI:2444243
Canis familiaris	MAP3K13	VGNC	VGNC:42969
Macaca mulatta	MAP3K13	VGNC	VGNC:74494

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