2. Gene
  3. UBE2L6 - ubiquitin conjugating enzyme E2 L6 Gene

UBE2L6 - ubiquitin conjugating enzyme E2 L6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RIG-B; UBCH8

Gene ID: 9246 | Gene type: protein coding

About UBE2L6

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,551,662-57,567,935 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues and 12 paralogues. Ubiquitous expression in spleen (RPKM 48.8), lymph node (RPKM 38.4) and 24 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is highly similar in primary structure to the Enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

UBE2L6 Products(2)

mRNA Protein Name
NM_004223.5 NP_004214.1 ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1
NM_198183.3 NP_937826.1 ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 2

UBE2L6 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (6 - 143)

  • 0
  • 100
  • 153 a.a.
Protein Preferred Names Protein Names

ubiquitin/ISG15-conjugating enzyme E2 L6

E2 ubiquitin-conjugating enzyme L6

Recombinant UBE2L6 Proteins

Cat. No. Product Name Accession Purity
HY-P71020 UBE2L6 Protein, Human (His) O14933 (M1-S153) ≥95%

Related Diseases

Diseases Alias
Immunodeficiency 38 With Basal Ganglia Calcification

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency

IMD38

Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive

Immunodeficiency 38

Isg15 Deficiency, Autosomal Recessive

Immunodeficiency 38, With Basal Ganglia Calcification

Autosomal Recessive Isg15 Deficiency

Msmd Due To Complete Isg15 Deficiency

Immunodeficiency, Type 38
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15354 UBE2L6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBE2L6 VGNC VGNC:36588
Rattus norvegicus UBE2L6 RGD RGD:1307960
Canis familiaris UBE2L6 VGNC VGNC:48058
Mus musculus UBE2L6 MGD MGI:1914500
Macaca mulatta UBE2L6 VGNC VGNC:78698
Felis catus UBE2L6 VGNC VGNC:66761
Others UBE2L6 NCBI