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  2. UBE2L6 - ubiquitin conjugating enzyme E2 L6 Gene

UBE2L6 - ubiquitin conjugating enzyme E2 L6 Gene

Homo sapiens

Also known as RIG-B; UBCH8

Gene ID: 9246 | Gene type: protein coding

About UBE2L6

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,551,662-57,567,935 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues and 12 paralogues. Ubiquitous expression in spleen (RPKM 48.8), lymph node (RPKM 38.4) and 24 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is highly similar in primary structure to the Enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

UBE2L6 Products(2)

mRNA Protein Name
NM_004223.5 NP_004214.1 ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1
NM_198183.3 NP_937826.1 ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ISG15 transferase activity IDA
IDA: Inferred from direct assay
15131269 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10085091 GOA
enables ubiquitin binding EXP
EXP: Inferred from Experiment
15485925 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ISG15-protein conjugation IDA
IDA: Inferred from direct assay
15131269 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
28724761 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2L6 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (6 - 143)

  • 0
  • 100
  • 153 a.a.
Protein Preferred Names Protein Names

ubiquitin/ISG15-conjugating enzyme E2 L6

E2 ubiquitin-conjugating enzyme L6

UBE2L6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBE2L6 O14933 RNF144B Homo sapiens Q7Z419 16427630
Intra
UBE2L6 O14933 DTX3 Homo sapiens Q8N9I9 32296183
Intra
UBE2L6 O14933 DTX3 Homo sapiens Q8N9I9 32296183
Intra
UBE2L6 O14933 DTX3 Homo sapiens Q8N9I9 32296183
Intra
UBE2L6 O14933 MID1 Homo sapiens O15344 32296183
Intra
UBE2L6 O14933 MID1 Homo sapiens O15344 32296183
Intra
UBE2L6 O14933 MID1 Homo sapiens O15344 32296183
Intra
UBE2L6 O14933 TRIM8 Homo sapiens Q9BZR9 19549727
Intra
UBE2L6 O14933 TRIM8 Homo sapiens Q9BZR9 32296183
Intra
UBE2L6 O14933 TRIM8 Homo sapiens Q9BZR9 32296183
Intra
UBE2L6 O14933 TRIM8 Homo sapiens Q9BZR9 32296183
Intra
UBE2L6 O14933 RBCK1 Homo sapiens Q9BYM8 25416956
Intra
UBE2L6 O14933 RBCK1 Homo sapiens Q9BYM8 32296183
Intra
UBE2L6 O14933 RBCK1 Homo sapiens Q9BYM8 32296183
Intra
UBE2L6 O14933 RBCK1 Homo sapiens Q9BYM8 32296183
Intra
UBE2L6 O14933 LONRF1 Homo sapiens Q17RB8 32296183
Intra
UBE2L6 O14933 LONRF1 Homo sapiens Q17RB8 32296183
Intra
UBE2L6 O14933 LONRF1 Homo sapiens Q17RB8 32296183
Intra
UBE2L6 O14933 RNF19B Homo sapiens Q6ZMZ0 16709802
Intra
UBE2L6 O14933 TRIM62 Homo sapiens Q9BVG3 32296183
Intra
UBE2L6 O14933 TRIM62 Homo sapiens Q9BVG3 32296183
Intra
UBE2L6 O14933 TRIM62 Homo sapiens Q9BVG3 32296183
Intra
UBE2L6 O14933 ARIH2 Homo sapiens O95376 19549727
Intra
UBE2L6 O14933 ARIH2 Homo sapiens O95376 25416956
Intra
UBE2L6 O14933 ARIH2 Homo sapiens O95376 33961781
Intra
UBE2L6 O14933 ARIH2 Homo sapiens O95376 32296183
Intra
UBE2L6 O14933 ARIH2 Homo sapiens O95376
Y2H
19549727
Intra
UBE2L6 O14933 ARIH2 Homo sapiens O95376 32296183
Intra
UBE2L6 O14933 ARIH2 Homo sapiens O95376 32296183
Intra
UBE2L6 O14933 ARIH2 Homo sapiens O95376 31515488
Intra
UBE2L6 O14933 RNF216 Homo sapiens Q9NWF9 32296183
Intra
UBE2L6 O14933 RNF216 Homo sapiens Q9NWF9 32296183
Intra
UBE2L6 O14933 RNF216 Homo sapiens Q9NWF9 32296183
Intra
UBE2L6 O14933 LITAF Homo sapiens Q99732 32814053
Intra
UBE2L6 O14933 LITAF Homo sapiens Q99732 32814053
Intra
UBE2L6 O14933 LITAF Homo sapiens Q99732 32814053
Cross
UBE2L6 O14933 Rnf40 Rattus norvegicus Q8CJB9 12121982
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2L6 Proteins

Cat. No. Product Name Accession Purity
HY-P71020 UBE2L6 Protein, Human (His) O14933 (M1-S153) ≥95%

Related Diseases

Diseases Alias
Immunodeficiency 38 With Basal Ganglia Calcification

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency

IMD38

Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive

Immunodeficiency 38

Isg15 Deficiency, Autosomal Recessive

Immunodeficiency 38, With Basal Ganglia Calcification

Autosomal Recessive Isg15 Deficiency

Msmd Due To Complete Isg15 Deficiency

Immunodeficiency, Type 38

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus UBE2L6 VGNC VGNC:36588
Rattus norvegicus UBE2L6 RGD RGD:1307960
Canis familiaris UBE2L6 VGNC VGNC:48058
Mus musculus UBE2L6 MGD MGI:1914500
Macaca mulatta UBE2L6 VGNC VGNC:78698
Felis catus UBE2L6 VGNC VGNC:66761
Others UBE2L6 NCBI