CD69 - CD69 molecule Gene

Homo sapiens

Also known as AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26

Gene ID: 969 | Gene type: protein coding

About CD69

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:9,752,486-9,760,901 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 23 paralogues. Biased expression in bone marrow (RPKM 55.9), lymph node (RPKM 41.3) and 13 other tissues.

Summary

This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

CD69 Products(1)

mRNA	Protein	Name
NM_001781.2	NP_001772.1	early activation antigen CD69

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	11101293	GOA
enables molecular sequestering activity	IDA IDA: Inferred from direct assay	37039481	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16525420	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	24752896	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of T cell migration	IDA IDA: Inferred from direct assay	37039481	GOA
involved in negative regulation of T-helper 17 cell lineage commitment	IDA IDA: Inferred from direct assay	24752896	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	37039481	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11101293	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD69 Protein Structure

Lectin_C

0
100
199 a.a.

Protein Preferred Names

Protein Names

early activation antigen CD69

C-type lectin domain family 2, member C

Recombinant CD69 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72713	CD69 Protein, Human (HEK293, His)	Q07108 (G64-K199)	≥95%

Related Diseases

Diseases

Alias

Coccidioidomycosis

Valley Fever	Primary Extrapulmonary Coccidioidomycosis
Coccidioides Immitis Infection	Coccidiosis
Coccidioides Infection	Coccidioidomycosis, Unspecified
San Joaquin Fever	California Disease
Desert Fever	Desert Rheumatism
San Joaquin Valley Fever	Enteric Coccidiosis
Primary Pulmonary Coccidioidomycosis	Acute Coccidioidomycosis
Posadas Wernicke Disease

Eosinophilic Pneumonia

Pneumonia, Eosinophilic	Pulmonary Eosinophilia
Asthmatic Pulmonary Eosinophilia	Pneumonia Eosinophilic
Simple Pulmonary Eosinophilia	Eosinophilic Asthma

Milk Allergy

Milk Allergic Reaction	Milk Hypersensitivity
Allergy Milk

Intermediate Uveitis

Uveitis, Intermediate	Chronic Cyclitis
Peripheral Uveoretinitis	Iu
Uveitis Intermediate

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Peritonitis

Retractile Mesenteritis	Sclerosing Mesenteritis
Acute Generalized Peritonitis	Primary Bacterial Peritonitis
Idiopathic Sclerosing Mesenteritis	Mesenteric Panniculitis
Peritoneal Retractile Mesenteritis	Liposclerotic Mesenteritis
Mesenteric Fibromatosis	Mesenteric Lipodystrophy
Mesenteric Lipogranuloma	Fibromatosis, Abdominal
Peritoneum Inflammation	Peritonitis Of Undetermined Cause
Peritonitis Of Unspecified Cause	Pelviperitonitis
Pelvic Peritonitis, Nos	Generalised Peritonitis Nos
Abdominal Peritonitis	Acute Idiopathic Peritonitis
Acute Lesser Sac Peritonitis	Acute Peritoneal Inflammation
Diffuse Peritonitis	Peritoneal Inflammation
Acute Primary Peritonitis	Pneumococcal Peritonitis

Uveitis

Synovitis

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Leishmaniasis

Post-Kala-Azar Dermal Leishmaniasis	Post Kala-Azar Dermal Leishmaniasis
Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis	Cutaneous Leishmaniasis
Kala-Azar	Visceral Leishmaniasis
Leishmaniasis, Cutaneous	Leishmaniasis, Visceral
Leishmania	Leishmania Infection
Leishmaniosis

Hypereosinophilic Syndrome

Eosinophilia	HES
Eosinophilic Leukocytosis	Hypereosinophilic Syndrome, Idiopathic
Idiopathic Hypereosinophilic Syndrome	Disseminated Eosinophilic Collagen Disease
Eosinophilic Disorder	Disorders With Increased Eosinophil Counts

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Psoriasis

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Carbapenem Allergy

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Primary Bacterial Infectious Disease

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155978A	RDN2150 TFA		99.49%	Unkown
HY-108944	LYP-IN-1	Inhibitor	99.78%	Unkown
HY-155978	RDN2150		/	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-145884	BTK-IN-8	Inhibitor	/	Unkown
HY-152201	BTK-IN-18	Inhibitor	/	Unkown
HY-18164	TASP0277308	Antagonist	/	Unkown
HY-RS02262	CD69 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-159123	KHK-6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD69	VGNC	VGNC:70776
Mus musculus	CD69	MGD	MGI:88343
Felis catus	CD69	VGNC	VGNC:83519
Rattus norvegicus	CD69	RGD	RGD:61318
Canis familiaris	CD69	VGNC	VGNC:38968
Bos taurus	CD69	VGNC	VGNC:27043
Macaca fascicularis	CD69	NCBI	NCBI:102141561
Others	CD69	NCBI