CDC25C - cell division cycle 25C Gene

Homo sapiens

Also known as CDC25; PPP1R60

Gene ID: 995 | Gene type: protein coding

About CDC25C

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,285,265-138,338,355 (from NCBI)

This gene has 9 transcripts (splice variants), 122 orthologues and 2 paralogues. Biased expression in testis (RPKM 7.7), bone marrow (RPKM 1.3) and 8 other tissues.

Summary

This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]

CDC25C Products(8)

mRNA	Protein	Name
NM_001287582.2	NP_001274511.1	M-phase inducer phosphatase 3 isoform a
NM_001287583.2	NP_001274512.1	M-phase inducer phosphatase 3 isoform c
NM_001318098.2	NP_001305027.1	M-phase inducer phosphatase 3 isoform e
NM_001364026.1	NP_001350955.1	M-phase inducer phosphatase 3 isoform f
NM_001364027.1	NP_001350956.1	M-phase inducer phosphatase 3 isoform g
NM_001364028.1	NP_001350957.1	M-phase inducer phosphatase 3 isoform h
NM_001790.5	NP_001781.2	M-phase inducer phosphatase 3 isoform a
NM_022809.4	NP_073720.1	M-phase inducer phosphatase 3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables WW domain binding	IPI IPI: Inferred from physical interaction	10037602	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9543386	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	9543386	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G2/M transition of mitotic cell cycle	IGI IGI: Inferred from genetic interaction	2195549	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	14968113	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC25C Protein Structure

M-inducer_phosp

Rhodanese

0
100
200
300
400
473 a.a.

Protein Preferred Names

Protein Names

M-phase inducer phosphatase 3

CDC25 homolog C

CDC25C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDC25C	P30307	LZTS1	Homo sapiens	Q9Y250	Anti Tag CoIP	17349584
Intra	CDC25C	P30307	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	27880917
Intra	CDC25C	P30307	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	CDC25C	P30307	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	CDC25C	P30307	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	27880917
Intra	CDC25C	P30307	YWHAB	Homo sapiens	P31946	Pull Down	28330616
Intra	CDC25C	P30307	YWHAB	Homo sapiens	P31946	Anti Bait CoIP	19470455
Intra	CDC25C	P30307	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	27880917
Intra	CDC25C	P30307	CDK1	Homo sapiens	P06493	Anti Tag CoIP	17349584
Intra	CDC25C	P30307	CDK1	Homo sapiens	P06493	Anti Tag CoIP	27880917
Intra	CDC25C	P30307	PLK1	Homo sapiens	P53350	Pull Down	12595692
Intra	CDC25C	P30307	CHEK1	Homo sapiens	O14757	Protein Kinase Assay	16330544
Intra	CDC25C	P30307	CHEK1	Homo sapiens	O14757	Protein Kinase Assay	11836499

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100034	NSC 663284	Inhibitor	99.79%	Unkown
HY-108543	NSC 95397		≥99.0%	Unkown
HY-112356	Scytonemin	Inhibitor	99.53%	Unkown
HY-107407	SB-218078		98.3%	Unkown
HY-112776A	BN82002 hydrochloride	Inhibitor	99.36%	Unkown
HY-128769	M2N12	Inhibitor	98.19%	Unkown
HY-121065	BN-82685	Inhibitor	99.05%	Unkown
HY-132578	M5N36	Inhibitor	98.05%	Unkown
HY-112776	BN82002	Inhibitor	/	Unkown
HY-118529	JUN-1111	Inhibitor	98.57%	Unkown
HY-P10574	Phosphorylated CHKtide		/	Unkown
HY-RS02293	CDC25C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W276819	PLK1-IN-9	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC25C	VGNC	VGNC:60651
Rattus norvegicus	CDC25C	RGD	RGD:1311875
Mus musculus	CDC25C	MGD	MGI:88350
Macaca mulatta	CDC25C	VGNC	VGNC:70796
Canis familiaris	CDC25C	VGNC	VGNC:38991
Bos taurus	CDC25C	VGNC	VGNC:27064

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