2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. LBM22

LBM22 is a CDC2-like kinase 2 (CLK2) inhibitor with the IC50 of 3.9 nM. LBM22 has antiproliferative activity and inhibits serine/arginine-rich (SR) protein phosphorylation. LBM22 down-regulates the expression of Wnt-related proteins and anti-apoptotic proteins and can be used for study of non-small cell lung cancer.

For research use only. We do not sell to patients.

LBM22 Chemical Structure

LBM22 Chemical Structure

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LBM22 Related Antibodies

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Description

LBM22 is a CDC2-like kinase 2 (CLK2) inhibitor with the IC50 of 3.9 nM. LBM22 has antiproliferative activity and inhibits serine/arginine-rich (SR) protein phosphorylation. LBM22 down-regulates the expression of Wnt-related proteins and anti-apoptotic proteins and can be used for study of non-small cell lung cancer[1].

Molecular Weight

512.51

Formula

C28H22F2N6O2
SMILES

FC1(F)CN(CC2=CN=CC(C3=CC4=C(NN=C4C5=NC(C6=CC=CO6)=C(C7=CC=CO7)N5)C=C3)=C2)CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LBM22 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LBM22LBM 22LBM-22CDKApoptosisCyclin dependent kinaseH1299 cellsnon-small cell lung cancerInhibitorinhibitorinhibit

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