Lipopolysaccharides, from S. enterica serotype enteritidis (Synonyms: LPS, from Salmonella enterica (Serotype enteritidis))

Cat. No.: HY-D1056C1: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis are lipopolysaccharide endotoxins and TLR-4 activators derived from the enteritidis serotype of S. enterica, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. enterica serotype enteritidis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype enteritidis can induce systemic inflammatory responses, increasing levels of TNF-α, IFN-γ, IL-6, IL-10, and nitrate in plasma.

For research use only. We do not sell to patients.

Lipopolysaccharides, from S. enterica serotype enteritidis Chemical Structure

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This product is a controlled substance and not for sale in your territory.

Other Forms of Lipopolysaccharides, from S. enterica serotype enteritidis:

Lipopolysaccharides, from E. coli O55:B5 Get quote
Lipopolysaccharides, from E. coli O111:B4 Get quote
Lipopolysaccharides, from E. coli O127:B8 Get quote
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Lipopolysaccharides, from E. coli O128:B12 Get quote
Lipopolysaccharides, from E. coli K-235 Get quote
Lipopolysaccharides, from Proteus vulgaris Get quote
Lipopolysaccharides, from Proteus mirabilis Get quote
Lipopolysaccharides, from Klebsiella pneumoniae Get quote
Lipopolysaccharides, from Salmonella typhosa Get quote
Lipopolysaccharides, from S. enterica serotype minnesota Get quote
Lipopolysaccharides, from S. enterica serotype typhimurium Get quote
Lipopolysaccharides, from S. enterica serotype abortus equi Get quote
Lipopolysaccharides, from P. gingivalis Get quote
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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

TLR-4^[2]

In Vitro

Note:
To maintain the integrity of LPS, it is recommended to store LPS solution in silanized containers. This is because LPS can adhere to plastics and certain types of glass, particularly at concentrations below 0.1 mg/mL. If the LPS concentration exceeds 1 mg/mL, this adsorption effect is relatively minimal. If using glass containers, ensure that the solution is thoroughly mixed for at least 30 minutes before use to redissolve any LPS that may have adsorbed to the tube walls.

Lipopolysaccharides, from S. enterica serotype enteritidis, mediate a lesser degree of oxidative stress compared to the pathogen's flagellin and only cause kidney injury rather than liver damage. Lipopolysaccharides, from S. enterica serotype enteritidis, induce the retention of polymorphonuclear neutrophils in the lungs of mice (increased myeloperoxidase activity), whereas only LPS recruits neutrophils in the intestine^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lipopolysaccharides, from S. enterica serotype enteritidis (4 mg/kg, 0.2 mL; IV; single dose) induce significant release of TNF-α, IFN-γ, IL-6, and IL-10 in a mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BALB/c mice (8 to 10 weeks old, 25 to 30 g)^[1]
Dosage:	(1) 100 μg (4 mg/kg), given in 0.2 mL of vehicle (10 mM PBS [pH 7.4]). (2) 20 μg/mous or 10 μg of LPS plus 10 μg of flagellin/mouse.
Administration:	Intravenous injection, via the tail vein; single dose.
Result:	Induced a significant increase in MPO after 8 h in n the liver and kidney. Decreased the levels of reduced glutathione in tissue in a comparable way in the lung, gut, and kidney. Compared treatment separately, significantly enhanced the release of both cytokines when injected LPS and flagellin together.

Appearance

Solid

Color

White to off-white

SMILES

[Lipopolysaccharides, from S. enterica serotype enteritidis]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (240 KB)

Handling Instructions (2659 KB)

References

[1]. Liaudet L, et al. Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide. Infect Immun. 2002 Jan;70(1):192-8. [Content Brief]

[2]. Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32. [Content Brief]

Lipopolysaccharides, from S. enterica serotype enteritidis Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from S. enterica serotype enteritidisLPS, from Salmonella enterica (Serotype enteritidis)Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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