2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Lipopolysaccharides, from P. aeruginosa 10

Lipopolysaccharides, from P. aeruginosa 10  (Synonyms: LPS, from Pseudomonas aeruginosa (10))

Cat. No.: HY-D1056E
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Lipopolysaccharides from P. aeruginosa (Pseudomonas aeruginosa) 10 are lipopolysaccharide endotoxins and TLR4 activators derived from Pseudomonas aeruginosa 10, and are classified as S-type LPS. Lipopolysaccharides from P. aeruginosa 10 exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. The lipopolysaccharides of P. aeruginosa 10 have a fatty acid composition distinct from common enterobacteria, an exceptionally high degree of phosphorylation (triphosphate residues have been detected), and a unique outer region of the core oligosaccharide. Additionally, their O-specific side chains are typically rich in novel aminosugars. Lipopolysaccharides from P. aeruginosa 10 demonstrate susceptibility to viruses, with the level of susceptibility determined by the content of high molecular weight polysaccharides in their composition. The absence of high molecular weight polysaccharides increases their sensitivity to bacteriophages.

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Lipopolysaccharides, from P. aeruginosa 10 Chemical Structure

Lipopolysaccharides, from P. aeruginosa 10 Chemical Structure

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Lipopolysaccharides, from P. aeruginosa 10 Related Antibodies

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Description

Lipopolysaccharides from P. aeruginosa (Pseudomonas aeruginosa) 10 are lipopolysaccharide endotoxins and TLR4 activators derived from Pseudomonas aeruginosa 10, and are classified as S-type LPS. Lipopolysaccharides from P. aeruginosa 10 exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. The lipopolysaccharides of P. aeruginosa 10 have a fatty acid composition distinct from common enterobacteria, an exceptionally high degree of phosphorylation (triphosphate residues have been detected), and a unique outer region of the core oligosaccharide. Additionally, their O-specific side chains are typically rich in novel aminosugars. Lipopolysaccharides from P. aeruginosa 10 demonstrate susceptibility to viruses, with the level of susceptibility determined by the content of high molecular weight polysaccharides in their composition. The absence of high molecular weight polysaccharides increases their sensitivity to bacteriophages[1][2][3].

IC50 & Target

TLR-4[2]
In Vitro

Note:
To maintain the integrity of LPS, it is recommended to store LPS solution in silanized containers. This is because LPS can adhere to plastics and certain types of glass, particularly at concentrations below 0.1 mg/mL. If the LPS concentration exceeds 1 mg/mL, this adsorption effect is relatively minimal. If using glass containers, ensure that the solution is thoroughly mixed for at least 30 minutes before use to redissolve any LPS that may have adsorbed to the tube walls.

P. aeruginosa 10 can simultaneously produce two types of O-antigens: common polysaccharide antigen (CPA) and O-specific antigen (OSA). CPA has a common conserved structure, composed of repeating units of "→3)d-Rha(α1→3)d-Rha(α1→2)d-Rha(α1→", while the structure of OSA is highly variable and serves as the determining factor for grouping the bacteria in serotyping. OSA plays a role in the early stages of biofilm development, and the evolution of CPA enables Pseudomonas aeruginosa to adapt to its environment, forming biofilms on plants and in soil[1].
The lipid A of Pseudomonas aeruginosa LPS is typically hexa-acylated and hepta-acylated, exhibiting more potent inflammatory-inducing activity compared to the typical penta-acylated lipids. Additionally, hepta-acylated lipid A is often associated with late-stage infections[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lipopolysaccharides, from P. aeruginosa 10 Related Antibodies
Appearance

Solid

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White to off-white

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[Lipopolysaccharides, from P. aeruginosa 10]
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Room temperature in continental US; may vary elsewhere.
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4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (Need ultrasonic)

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Lipopolysaccharides, from P. aeruginosa 10 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from P. aeruginosa 10LPS, from Pseudomonas aeruginosa (10)Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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