2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Lipopolysaccharides, from Klebsiella pneumoniae

Lipopolysaccharides, from Klebsiella pneumoniae  (Synonyms: LPS, from bacterial (Klebsiella pneumoniae))

Cat. No.: HY-D1056B3
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Lipopolysaccharides, from Klebsiella, are lipopolysaccharide endotoxins. Lipopolysaccharides, from Klebsiella pneumoniae, consist of three parts: lipid A, core oligosaccharide, and O-specific antigen or O-side chain. In smooth LPS, the core region is divided into two areas: the inner core near the lipid A and the outer core that provides attachment sites for the O-antigen. In the lipopolysaccharide of Klebsiella pneumoniae, the l,d-HeppII at the O-3 position can be replaced by an α-d-galacturonic acid residue (α-d-GalpA). In most studied Enterobacteriaceae, the core LPS contains inner core phosphorylation modifications, but the core LPS of Klebsiella pneumoniae lacks this modification. The unique core structure plays an important role in the outer membrane permeability and pathogenesis of Klebsiella pneumoniae.

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Lipopolysaccharides, from Klebsiella pneumoniae Chemical Structure

Lipopolysaccharides, from Klebsiella pneumoniae Chemical Structure

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Lipopolysaccharides, from Klebsiella pneumoniae Related Antibodies

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Description

Lipopolysaccharides, from Klebsiella, are lipopolysaccharide endotoxins. Lipopolysaccharides, from Klebsiella pneumoniae, consist of three parts: lipid A, core oligosaccharide, and O-specific antigen or O-side chain. In smooth LPS, the core region is divided into two areas: the inner core near the lipid A and the outer core that provides attachment sites for the O-antigen. In the lipopolysaccharide of Klebsiella pneumoniae, the l,d-HeppII at the O-3 position can be replaced by an α-d-galacturonic acid residue (α-d-GalpA). In most studied Enterobacteriaceae, the core LPS contains inner core phosphorylation modifications, but the core LPS of Klebsiella pneumoniae lacks this modification. The unique core structure plays an important role in the outer membrane permeability and pathogenesis of Klebsiella pneumoniae[1][2][3][4][5].

IC50 & Target

TLR-4[2]
Appearance

Solid

Color

White to off-white

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[Lipopolysaccharides, from Klebsiella pneumoniae]
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Room temperature in continental US; may vary elsewhere.
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Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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H2O : 5 mg/mL (Need ultrasonic and warming)

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Lipopolysaccharides, from Klebsiella pneumoniae Related Classifications

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Keywords:

Lipopolysaccharides, from Klebsiella pneumoniaeLPS, from bacterial (Klebsiella pneumoniae)Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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