2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Lipopolysaccharides, from Proteus mirabilis

Lipopolysaccharides, from Proteus mirabilis  (Synonyms: LPS, from bacterial (Proteus mirabilis))

Cat. No.: HY-D1056B2
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Lipopolysaccharides, from Proteus mirabilis are lipopolysaccharide endotoxins and TLR-4 activators derived from Proteus mirabilis, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from Proteus mirabilis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Proteus mirabilis is a major pathogen causing urinary tract infections and may also contribute to rheumatoid arthritis. Lipopolysaccharides, from Proteus mirabilis also exhibit potential anti-tumor effects, demonstrating in vivo inhibitory activity against solid tumors such as meningosarcoma and Walker carcinosarcoma.

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Lipopolysaccharides, from Proteus mirabilis Chemical Structure

Lipopolysaccharides, from Proteus mirabilis Chemical Structure

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Lipopolysaccharides, from Proteus mirabilis Related Antibodies

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Description

Lipopolysaccharides, from Proteus mirabilis are lipopolysaccharide endotoxins and TLR-4 activators derived from Proteus mirabilis, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from Proteus mirabilis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Proteus mirabilis is a major pathogen causing urinary tract infections and may also contribute to rheumatoid arthritis. Lipopolysaccharides, from Proteus mirabilis also exhibit potential anti-tumor effects, demonstrating in vivo inhibitory activity against solid tumors such as meningosarcoma and Walker carcinosarcoma[1][2].

IC50 & Target

TLR-4[2]
In Vitro

Note:
To maintain the integrity of LPS, it is recommended to store LPS solution in silanized containers. This is because LPS can adhere to plastics and certain types of glass, particularly at concentrations below 0.1 mg/mL. If the LPS concentration exceeds 1 mg/mL, this adsorption effect is relatively minimal. If using glass containers, ensure that the solution is thoroughly mixed for at least 30 minutes before use to redissolve any LPS that may have adsorbed to the tube walls.

Serum-mediated immunity functions by activating the complement cascade, producing the membrane attack complex C5b-9, which exerts its own bactericidal activity. Lipopolysaccharides, from Proteus mirabilis are capable of activating the complement system and inducing C5b deposition. After incubation with serum for 3 hours (37 °C), Lipopolysaccharides, from Proteus mirabilis inhibit bacterial viability[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lipopolysaccharides, from Proteus mirabilis Related Antibodies
In Vivo

Lipopolysaccharides, from Proteus mirabilis (minimum effective dose 0.005 mg/kg; intravenous or intraperitoneal injection; single dose) effectively suppress solid Ehrlich carcinoma (ED=0.005 mg/kg), Sarcoma 180, Sarcoma 37, and other solid tumors in mouse and rat tumor-bearing models, causing complete regression of some tumors. However, Lipopolysaccharides, from Proteus mirabilis are ineffective against ascites-type tumors. Lipopolysaccharides, from Proteus mirabilis can block blood flow in tumor tissues, causing the injected material to be "locked out" or "locked in." Lipopolysaccharides, from Proteus mirabilis can also be combined with anti-tumor drugs such as 6-mercaptopurine (HY-13677) and Cyclophosphamide (HY-17420) to enhance the inhibitory effects on refractory tumors like Meningeal sarcoma MS-147 and Walker carcinosarcoma 256[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing solid-type Ehrlich carcinoma, Sarcoma 180, Sarcoma 37, Meningeal sarcoma MS-147, Walker carcinosarcoma 256, Adenocarcinoma 755, Yoshida sarcoma, C3H spontaneous sarcoma, Lymphoid leukemia L 1210; Rats bearing Walker carcinosarcoma 256[2].
Dosage: LPS from wild type and heptoseless mutant N-434 of Proteus mirabilis RMS-203, with doses varying in different experiments.
Administration: Intravenous or intraperitoneal injection, subcutaneous injection (for some experiments); evaluating tumor regression in 2-4 weeks.
Result: LPS from both wild type and heptoseless mutant of Proteus mirabilis RMS-203 had the same level of activity when given intravenously in the Pigment test on Ehrlich solid tumor.
Inhibited the growth of solid-type Ehrlich carcinoma, Sarcoma 180, and Sarcoma 37, and could cause complete regression of these tumors.
Exhibited a vascular effect on tumor tissues, it could not be ineffective against ascites-type tumors.
SMILES

[Lipopolysaccharides, from Proteus mirabilis]
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Lipopolysaccharides, from Proteus mirabilis Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lipopolysaccharides, from Proteus mirabilisLPS, from bacterial (Proteus mirabilis)Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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