2. Apoptosis Epigenetics
  3. Apoptosis Epigenetic Reader Domain
  4. Menin-MLL inhibitor-25

Menin-MLL inhibitor-25 (compound A6) is a potent Menin-MLL interaction inhibitor with an IC50 value of 0.38 µM. Menin-MLL inhibitor-25 shows anti-proliferative activity. Menin-MLL inhibitor-25 induces apoptosis and cell cycle arrest at G0/G1 phase. Menin-MLL inhibitor-25 reverses the differentiation arrest.

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Menin-MLL inhibitor-25 Chemical Structure

Menin-MLL inhibitor-25 Chemical Structure

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Menin-MLL inhibitor-25 Related Antibodies

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Description

Menin-MLL inhibitor-25 (compound A6) is a potent Menin-MLL interaction inhibitor with an IC50 value of 0.38 µM. Menin-MLL inhibitor-25 shows anti-proliferative activity. Menin-MLL inhibitor-25 induces apoptosis and cell cycle arrest at G0/G1 phase. Menin-MLL inhibitor-25 reverses the differentiation arrest[1].

In Vitro

Menin-MLL inhibitor-25 (compound A6) (0-10 µM) shows anti-proliferation activity with IC50s of 1.07, >10, 6.7 µM for MV4-11, HL-60, SU-DHL-6 cells, respectively. [1].
Menin-MLL inhibitor-25 (0.1, 1, 10 µM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase in MV4-11 cells[1].
Menin-MLL inhibitor-25 (0.1, 0.5 µM; 24, 48 h) decreases the HOXA9 and MEIS1 gene expression in a time and dose dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Menin-MLL inhibitor-25 Related Antibodies

Cell Viability Assay[1]

Cell Line: MV4-11, HL-60, SU-DHL-6 cells
Concentration: 0-10 µM
Incubation Time:
Result: Showed anti-proliferation activity with IC50s of 1.07, >10, 6.7 µM for MV4-11, HL-60, SU-DHL-6 cells, respectively.

Apoptosis Analysis[1]

Cell Line: MV4-11 cells
Concentration: 0.1, 1, 10 µM
Incubation Time: 24 h
Result: Induced apoptosis with the apoptosis rates of 6.09 %, 8.86 % and 43.08 % at 0.1, 1 and 10 μM.

Cell Cycle Analysis[1]

Cell Line: MV4-11 cells
Concentration: 0.01, 0.1, 1 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G0/G1 phase in a dose-dependent manner.

RT-PCR[1]

Cell Line: MV4-11 cells
Concentration: 0.1, 0.5 µM
Incubation Time: 24, 48 h
Result: Decreasesd the gene expression of HOXA9 and MEIS1 in a time and dose dependent manner.
Molecular Weight

481.57

Formula

C28H28FN7
SMILES

N#CC1=CC=C(N2CC(CN3CCC(N4C=C(C5=CC=C(F)C=C5)C6=C(N)N=CN=C64)CC3)C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Menin-MLL inhibitor-25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Menin-MLL inhibitor-25ApoptosisEpigenetic Reader DomainMV4-11 cellsapoptosisG0/G1anti-proliferativedifferentiation arrestInhibitorinhibitorinhibit

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