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Sodium 2-mercaptoethanesulfonate  (Synonyms: Sodium 2-mercaptoethanesulfonate; Mesnum)

Cat. No.: HY-13679 Purity: 99.78%
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Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide.

For research use only. We do not sell to patients.

Sodium 2-mercaptoethanesulfonate Chemical Structure

Sodium 2-mercaptoethanesulfonate Chemical Structure

CAS No. : 19767-45-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 61 In-stock
Solution
10 mM * 1 mL in Water USD 61 In-stock
Solid
500 mg USD 55 In-stock
5 g USD 66 In-stock
10 g USD 105 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Sodium 2-mercaptoethanesulfonate:

Sodium 2-mercaptoethanesulfonate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sodium 2-mercaptoethanesulfonate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide[1][2].

Cellular Effect
Cell Line Type Value Description References
HL-60 CC50
> 400 μM
Compound: mesna
Cytotoxicity against human HL60 cells in presence of RPMI1640 containing 10% fetal bovine serum by trypan blue exclusion test
Cytotoxicity against human HL60 cells in presence of RPMI1640 containing 10% fetal bovine serum by trypan blue exclusion test
[PMID: 17499885]
HSC-2 CC50
> 400 μM
Compound: mesna
Cytotoxicity against human HSC2 by MTT method
Cytotoxicity against human HSC2 by MTT method
[PMID: 17499885]
HSC-4 CC50
> 400 μM
Compound: mesna
Cytotoxicity against human HSC4 cells by MTT method
Cytotoxicity against human HSC4 cells by MTT method
[PMID: 17499885]
L1210 IC50
> 200 μM
Compound: Mesna
Concentration required to reduce the viability of L1210 cells by 50% after 1-h incubation at 37 degrees C
Concentration required to reduce the viability of L1210 cells by 50% after 1-h incubation at 37 degrees C
[PMID: 1992116]
In Vitro

Mesna (1-1000 μM) reduces H2O2, HOCl and OH concentrations in a dose-dependent manner, with an IC50 of 32, 21, and 305 μM, respectively in cell-free experiments[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium 2-mercaptoethanesulfonate Related Antibodies
In Vivo

Mesna (150 mg/kg; a single i.p.) protects the rat brain against traumatic injury[1].
Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI)[1]
Dosage: 150 mg/kg
Administration: A single i.p.
Result: Decreased tissue malondialdehyde levels.
Increased the activity of glutathione peroxidase and superoxide dismutase.
Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase.
Protected the brain tissues well from injury.
Molecular Weight

164.18

Formula

C2H5NaO3S2
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

SCCS(=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1522.72 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 50 mg/mL (304.54 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0909 mL 30.4544 mL 60.9088 mL
5 mM 1.2182 mL 6.0909 mL 12.1818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (609.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.78%

SDS (393 KB)

COA (248 KB) HNMR (224 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.0909 mL 30.4544 mL 60.9088 mL 152.2719 mL
5 mM 1.2182 mL 6.0909 mL 12.1818 mL 30.4544 mL
10 mM 0.6091 mL 3.0454 mL 6.0909 mL 15.2272 mL
15 mM 0.4061 mL 2.0303 mL 4.0606 mL 10.1515 mL
20 mM 0.3045 mL 1.5227 mL 3.0454 mL 7.6136 mL
25 mM 0.2436 mL 1.2182 mL 2.4364 mL 6.0909 mL
30 mM 0.2030 mL 1.0151 mL 2.0303 mL 5.0757 mL
40 mM 0.1523 mL 0.7614 mL 1.5227 mL 3.8068 mL
50 mM 0.1218 mL 0.6091 mL 1.2182 mL 3.0454 mL
60 mM 0.1015 mL 0.5076 mL 1.0151 mL 2.5379 mL
80 mM 0.0761 mL 0.3807 mL 0.7614 mL 1.9034 mL
100 mM 0.0609 mL 0.3045 mL 0.6091 mL 1.5227 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium 2-mercaptoethanesulfonate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium 2-mercaptoethanesulfonate19767-45-4 MesnumOthersantioxidantcytoprotectivechemotherapytoxicityhemorrhagiccystitiscyclophosphamideInhibitorinhibitorinhibit

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