2. Apoptosis
  3. MDM-2/p53
  4. MI 63

MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS.

For research use only. We do not sell to patients.

MI 63 Chemical Structure

MI 63 Chemical Structure

CAS No. : 908027-21-4

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MI 63 Related Antibodies

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Description

MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS[1].

Molecular Weight

577.52

Formula

C29H35Cl2FN4O3
CAS No.
SMILES

O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MI 63 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI 63908027-21-4MI63MI-63MDM-2/p53RH36RH18RH30HCT116rhabdomyosarcomaRMSERMSARMSInhibitorinhibitorinhibit

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