2. Apoptosis
  3. MDM-2/p53
  4. MI 63

MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS.

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MI 63 Chemical Structure

MI 63 Chemical Structure

CAS No. : 908027-21-4

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MI 63 Related Antibodies

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Description

MI 63 is an activator for p53, by targeting the MDM2 (Ki is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC50 is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS[1].

Cellular Effect
Cell Line Type Value Description References
A2780 GI50
1.19 μM
Compound: 2a, MI-63
Growth inhibition of human A2780 cells expressing MDM2 by SRB assay
Growth inhibition of human A2780 cells expressing MDM2 by SRB assay
[PMID: 21875801]
HCT-116 IC50
0.7 μM
Compound: 1, MI-63
Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
[PMID: 19928922]
HCT-116 GI50
1.3 μM
Compound: 2a, MI-63
Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay
Growth inhibition of human HCT116 cells expressing MDM2 by SRB assay
[PMID: 21875801]
HCT-116 GI50
11.8 μM
Compound: 2a, MI-63
Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay
Growth inhibition of p53 deficient human HCT116 cells expressing MDM2 by SRB assay
[PMID: 21875801]
HCT-116 IC50
14.4 μM
Compound: 1, MI-63
Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
[PMID: 19928922]
SAOS-2 IC50
14.1 μM
Compound: 1, MI-63
Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay
[PMID: 19928922]
SJSA-1 IC50
0.5 μM
Compound: 1, MI-63
Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay
[PMID: 19928922]
SJSA-1 GI50
0.55 μM
Compound: 2a, MI-63
Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay
Growth inhibition of human SJSA1 cells expressing MDM2 by SRB assay
[PMID: 21875801]
Molecular Weight

577.52

Formula

C29H35Cl2FN4O3
CAS No.
SMILES

O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@]31C(NC4=C3C=CC(Cl)=C4)=O)NCCN5CCOCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MI 63 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI 63908027-21-4MI63MI-63MDM-2/p53RH36RH18RH30HCT116rhabdomyosarcomaRMSERMSARMSInhibitorinhibitorinhibit

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