2. NF-κB
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  4. MnTBAP chloride

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

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MnTBAP chloride Chemical Structure

MnTBAP chloride Chemical Structure

CAS No. : 55266-18-7

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Based on 2 publication(s) in Google Scholar

MnTBAP chloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MnTBAP chloride

WB

    MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2022 Nov 17;S0891-5849(22)00992-3.  [Abstract]

    The decreased protein expression levels of the ferroptosis repressors NRF2, SLC7A11, and GPX4 after cisplatin stimuli are rescued by 84-B10 (40 µM), MnTBAP (80 µM), and Lipro-1 (2 µM) pretreat for 2 h, in TKPT cells.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2].

    IC50 & Target[1][2]

    NFκB

     

    In Vitro

    MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs)[1].
    MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    MnTBAP chloride Related Antibodies
    In Vivo

    MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: C57BL/6J mice with 5/6 nephrectomy (Nx)[1]
    Dosage: 10 mg/kg
    Administration: IP; three times per week for twelve weeks
    Result: Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
    Molecular Weight

    879.15

    Formula

    C48H28ClMnN4O8
    CAS No.
    Appearance

    Solid

    Color

    Brown to black

    SMILES

    [Cl-][Mn+3]12([N](C(C=C3)=C4C(C=C5)=CC=C5C(O)=O)=C3C(C(C=C6)=CC=C6C(O)=O)=C7C=C8)[N-]7C8=C(C(C=C9)=CC=C9C(O)=O)C%10=[N]1C(C=C%10)=C(C(C=C%11)=CC=C%11C(O)=O)C%12=CC=C4[N-]2%12
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (113.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    0.5 M NaOH : 20 mg/mL (22.75 mM; Need ultrasonic)

    1M NaOH : 10 mg/mL (11.37 mM; ultrasonic and adjust pH to 8 with NaOH)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1375 mL 5.6873 mL 11.3746 mL
    5 mM 0.2275 mL 1.1375 mL 2.2749 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 4.17 mg/mL (4.74 mM); Clear solution

      This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 4.17 mg/mL (4.74 mM); Clear solution

      This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: ≥98.0%

    COA (263 KB) HNMR (359 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    1M NaOH / 0.5 M NaOH / DMSO 1 mM 1.1375 mL 5.6873 mL 11.3746 mL 28.4366 mL
    5 mM 0.2275 mL 1.1375 mL 2.2749 mL 5.6873 mL
    10 mM 0.1137 mL 0.5687 mL 1.1375 mL 2.8437 mL
    0.5 M NaOH / DMSO 15 mM 0.0758 mL 0.3792 mL 0.7583 mL 1.8958 mL
    20 mM 0.0569 mL 0.2844 mL 0.5687 mL 1.4218 mL
    DMSO 25 mM 0.0455 mL 0.2275 mL 0.4550 mL 1.1375 mL
    30 mM 0.0379 mL 0.1896 mL 0.3792 mL 0.9479 mL
    40 mM 0.0284 mL 0.1422 mL 0.2844 mL 0.7109 mL
    50 mM 0.0227 mL 0.1137 mL 0.2275 mL 0.5687 mL
    60 mM 0.0190 mL 0.0948 mL 0.1896 mL 0.4739 mL
    80 mM 0.0142 mL 0.0711 mL 0.1422 mL 0.3555 mL
    100 mM 0.0114 mL 0.0569 mL 0.1137 mL 0.2844 mL
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    MnTBAP chloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MnTBAP55266-18-7NF-κBNuclear factor-κBNuclear factor-kappaBsuperoxidedismutaseSODscavengeranti-oxidativeBMPR-IINFκBfibroticresponsechronickidneyCKDsInhibitorinhibitorinhibit

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