2. Cell Cycle/DNA Damage Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  3. HSP Potassium Channel
  4. NDNA4

NDNA4 (compound 17) is a selective inhibitor of Hsp90α (IC50: 0.34 μM). NDNA4 is a permanently charged analog with low membrane permeability and low cytotoxicity against Ovcar-8 and MCF-10A ((IC50 >100 μM)). NDNA4 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins.

For research use only. We do not sell to patients.

NDNA4 Chemical Structure

NDNA4 Chemical Structure

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NDNA4 Related Antibodies

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

NDNA4 (compound 17) is a selective inhibitor of Hsp90α (IC50: 0.34 μM). NDNA4 is a permanently charged analog with low membrane permeability and low cytotoxicity against Ovcar-8 and MCF-10A ((IC50 >100 μM)). NDNA4 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins[1].

IC50 & Target

IC50: 0.34 μM (Hsp90α)[1]
Molecular Weight

604.68

Formula

C31H35F3N2O5S
SMILES

C[N+](C)(C)CCCOC1=CC2=C(CN(C(C3=CC=C(O)C(SC4=CC=C(C)C(C)=C4)=C3)=O)C2)C=C1.O=C([O-])C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NDNA4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDNA4NDNA 4NDNA-4HSPPotassium ChannelHeat shock proteinsKcsAPermanently charged analogsLow membrane permeabilityOvcar-8MCF-10AInhibitorinhibitorinhibit

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