2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Nebivolol

Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease.

For research use only. We do not sell to patients.

Nebivolol Chemical Structure

Nebivolol Chemical Structure

CAS No. : 118457-14-0

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Based on 3 publication(s) in Google Scholar

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Nebivolol Related Antibodies

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α adrenergic receptor β adrenergic receptor

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  • References

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Description

Nebivolol (R 065824) is an orally active beta receptor blocker and has the high beta(1)-receptor affinity. Nebivolol has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease[1][2].

In Vitro

Nebivolol improves endothelial dysfunction via its strong stimulatory effects on the activity of the endothelial nitric oxide synthase and via its antioxidative properties[1].
Nebivolol (0.1 μM-10 μM, 1, 2, 4, 7 or 14 days) inhibits haCSMC or haEC proliferation with IC50 values of ~ 6.0 μM[2].
Nebivolol (0.1 μM-10 μM, 24 h) induces a moderate rate of apoptosis[2].
Nebivolol (0.1, 1, 5,10 μM, 4 days)increases NO formation and decreases endothelin-1 secretion in HaCEs[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nebivolol Related Antibodies

Cell Proliferation Assay[2]

Cell Line: haCSMCs (human coronary smooth muscle cells) and haECs (endothelial cells)
Concentration: 0.1 μM-10 μM
Incubation Time: 1, 2, 4, 7 or 14 days
Result: Reduced proliferation in HaECs and HaCSMCs in a concentration- and time-dependent.

Apoptosis Analysis[2]

Cell Line: haCSMCs and haECs
Concentration: 0.1 μM-10 μM
Incubation Time: 24 h
Result: Induced a moderate apoptosis in concentration-dependent and showed a decrease of haCSMCs in the S-phase by 66%.
Clinical Trial
Molecular Weight

405.44

Formula

C22H25F2NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C2C(CC[C@]([C@@H](O)CNC[C@H](O)[C@@]3([H])CCC(C=C(F)C=C4)=C4O3)([H])O2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (123.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4665 mL 12.3323 mL 24.6646 mL
5 mM 0.4933 mL 2.4665 mL 4.9329 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4665 mL 12.3323 mL 24.6646 mL 61.6614 mL
5 mM 0.4933 mL 2.4665 mL 4.9329 mL 12.3323 mL
10 mM 0.2466 mL 1.2332 mL 2.4665 mL 6.1661 mL
15 mM 0.1644 mL 0.8222 mL 1.6443 mL 4.1108 mL
20 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0831 mL
25 mM 0.0987 mL 0.4933 mL 0.9866 mL 2.4665 mL
30 mM 0.0822 mL 0.4111 mL 0.8222 mL 2.0554 mL
40 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.5415 mL
50 mM 0.0493 mL 0.2466 mL 0.4933 mL 1.2332 mL
60 mM 0.0411 mL 0.2055 mL 0.4111 mL 1.0277 mL
80 mM 0.0308 mL 0.1542 mL 0.3083 mL 0.7708 mL
100 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.6166 mL
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Nebivolol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nebivolol118457-14-0R 065824R065824R-065824Adrenergic ReceptorBeta Receptororalbeta receptorvasodilatoradrenergic blockinghypertensioncoronary artery diseasecongestive heart failureischemic heart diseaseInhibitorinhibitorinhibit

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