2. JAK/STAT Signaling Stem Cell/Wnt Anti-infection
  3. STAT Bacterial
  4. Ochromycinone

Ochromycinone  (Synonyms: (Rac)-STA-21)

Cat. No.: HY-18061 Purity: 98.13%
COA Handling Instructions

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Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity.

For research use only. We do not sell to patients.

Ochromycinone Chemical Structure

Ochromycinone Chemical Structure

CAS No. : 111540-00-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 187 In-stock
Solution
10 mM * 1 mL in DMSO USD 187 In-stock
Solid
1 mg USD 120 In-stock
5 mg USD 170 In-stock
10 mg USD 290 In-stock
25 mg USD 610 In-stock
50 mg USD 1050 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Ochromycinone:

Ochromycinone Related Antibodies

Top Publications Citing Use of Products

    Ochromycinone purchased from MedChemExpress. Usage Cited in: Nutrients. 2016 May 11;8(5). pii: E280.  [Abstract]

    Levels of p-STAT3 are determined by Western blotting and the levels of IL-6 and IL-8 are determined by ELISA assay, in MΦ cultures. Effect of treatment with IL-1β, IL-6, aIL-6 or STA21. Co, control. Representative data from one of three experiments are shown.

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    STAT3 STAT5 STAT6 STAT1

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity[1][2].

    IC50 & Target[2]

    STAT3

     

    In Vitro

    STA-21 inhibits STAT3 DNA binding activity, STAT3 dimerization, and STAT3-dependent luciferase activity. Moreover, STA-21 reduces the survival of breast carcinoma cells with constitutive STAT3 signaling but has minimal effect on the cells in which constitutive STAT3 signaling is absent[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ochromycinone Related Antibodies
    Molecular Weight

    306.31

    Formula

    C19H14O4
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    CC(CC1=O)CC2=C1C3=C(C=C2)C(C4=C(O)C=CC=C4C3=O)=O
    Structure Classification
    Initial Source

    Indonesian Streptomyces sp
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 16.67 mg/mL (54.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2647 mL 16.3233 mL 32.6467 mL
    5 mM 0.6529 mL 3.2647 mL 6.5293 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 1.67 mg/mL (5.45 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 98.29%

    COA (254 KB) HNMR (181 KB) LCMS (112 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.2647 mL 16.3233 mL 32.6467 mL 81.6167 mL
    5 mM 0.6529 mL 3.2647 mL 6.5293 mL 16.3233 mL
    10 mM 0.3265 mL 1.6323 mL 3.2647 mL 8.1617 mL
    15 mM 0.2176 mL 1.0882 mL 2.1764 mL 5.4411 mL
    20 mM 0.1632 mL 0.8162 mL 1.6323 mL 4.0808 mL
    25 mM 0.1306 mL 0.6529 mL 1.3059 mL 3.2647 mL
    30 mM 0.1088 mL 0.5441 mL 1.0882 mL 2.7206 mL
    40 mM 0.0816 mL 0.4081 mL 0.8162 mL 2.0404 mL
    50 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL
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    Ochromycinone Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ochromycinone111540-00-2(Rac)-STA-21STATBacterialSTAT3anticancerantibioticantimicrobialdimerizationDNAbindingInhibitorinhibitorinhibit

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