Pelargonidin chloride

Name: Pelargonidin chloride
Brand: MedChemExpress
SKU: HY-W011370
Rating: 4.5 (1 reviews)

Cat. No.: HY-W011370 Purity: 98.52%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment.

For research use only. We do not sell to patients.

Pelargonidin chloride Chemical Structure

CAS No. : 134-04-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Pelargonidin chloride (10-100 µM; 1, 3, 5 days) inhibits cell viability in a time- and dose-dependent manner in JB6 P+ cells^[2].
Pelargonidin chloride (10, 30, 50 µM; 3 days) induces cell cycle arrest at sub-G1 phase in a dose-dependent manner^[2].
Pelargonidin chloride (0,10, 30, 50 µM; 5 days) increases the mRNA and protein expression of HO-1, NQO1, Nrf2 in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:	JB6 P+ cells
Concentration:	10, 30, 50, 70, 100 μM
Incubation Time:	1, 3, 5 days
Result:	Showed cytotoxicity in a time- and dose-dependent manner.

Cell Cycle Analysis^[2]

Cell Line:	JB6 P+ cells
Concentration:	10, 30, 50 µM
Incubation Time:	3 days
Result:	Induced cell cycle arrest at sub-G1 phase in a dose-dependent manner.

RT-PCR^[2]

Cell Line:	JB6 P+ cells
Concentration:	0,10, 30, 50 µM
Incubation Time:	6h, 5 days
Result:	Promoted the mRNA expression of HO-1 and NQO1 after 6 hours and 5 days.

In Vivo

Pelargonidin (3 mg/kg; ip; once) chloride improves Aβ-induced memory and learning impairment in Morris water maze (MWM), increases the antioxidant power of hippocampus homogenate^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	250-300 g, 12 weeks Wistar rats (Aβ 25-35 (1 µg/µL for 5 μL, injectes bilaterally into the hippocampi)^[3]
Dosage:	3 mg/kg
Administration:	IP; once
Result:	Significant decreased in escape latency and traveled distance in comparison to the Aβ-treated group, increased the antioxidant power of hippocampus homogenate.

Molecular Weight

306.70

Formula

C₁₅H₁₁ClO₅

CAS No.

134-04-3

Appearance

Solid

Color

Brown to reddish brown

SMILES

OC1=CC=C(C2=C(O)C=C3C(C=C(O)C=C3O)=[O+]2)C=C1.[Cl-]

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (163.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2605 mL	16.3026 mL	32.6051 mL
5 mM	0.6521 mL	3.2605 mL	6.5210 mL
10 mM	0.3261 mL	1.6303 mL	3.2605 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.10%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (249 KB) HNMR (124 KB) RP-HPLC (87 KB) MS (114 KB)

Handling Instructions (2659 KB)

References

[1]. S A van Acke, et al. Flavonoids as Scavengers of Nitric Oxide Radical.Biochem Biophys Res Commun. 1995 Sep 25;214(3):755-9. [Content Brief]

[2]. Soleimani Asl S, et al. Pelargonidin exhibits restoring effects against amyloid β-induced deficits in the hippocampus of male rats. Med J Islam Repub Iran. 2019 Dec 12;33:135. [Content Brief]

[3]. Li S, et al. Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation. Chem Biol Interact. 2019 Aug 25;309:108701. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2605 mL	16.3026 mL	32.6052 mL	81.5129 mL
	5 mM	0.6521 mL	3.2605 mL	6.5210 mL	16.3026 mL
	10 mM	0.3261 mL	1.6303 mL	3.2605 mL	8.1513 mL
	15 mM	0.2174 mL	1.0868 mL	2.1737 mL	5.4342 mL
	20 mM	0.1630 mL	0.8151 mL	1.6303 mL	4.0756 mL
	25 mM	0.1304 mL	0.6521 mL	1.3042 mL	3.2605 mL
	30 mM	0.1087 mL	0.5434 mL	1.0868 mL	2.7171 mL
	40 mM	0.0815 mL	0.4076 mL	0.8151 mL	2.0378 mL
	50 mM	0.0652 mL	0.3261 mL	0.6521 mL	1.6303 mL
	60 mM	0.0543 mL	0.2717 mL	0.5434 mL	1.3585 mL
	80 mM	0.0408 mL	0.2038 mL	0.4076 mL	1.0189 mL
	100 mM	0.0326 mL	0.1630 mL	0.3261 mL	0.8151 mL