2. Metabolic Enzyme/Protease Apoptosis PI3K/Akt/mTOR Epigenetics
  3. Apoptosis Mitochondrial Metabolism AMPK
  4. Phenformin

Phenformin  (Synonyms: Phenethylbiguanide)

Cat. No.: HY-16397 Purity: 99.72%
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Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis.

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Phenformin Chemical Structure

Phenformin Chemical Structure

CAS No. : 114-86-3

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50 mg USD 218 In-stock
100 mg USD 318 In-stock
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Based on 7 publication(s) in Google Scholar

Other Forms of Phenformin:

Phenformin Related Antibodies

Top Publications Citing Use of Products

    Phenformin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Aug;128:110216.  [Abstract]

    Western blot analysis of p-AMPK, LC3B-I/II and NLRP3 after PSCs are pretreated with phenformin (Phe, AMPK activator) for 1 h followed by incubation with or without 10 μg/mL SSa for 24 h.

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    NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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    Description

    Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].

    Molecular Weight

    205.26

    Formula

    C10H15N5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NC(NC(NCCC1=CC=CC=C1)=N)=N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    RT, protect from light

    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    H2O : 350 mg/mL (1705.15 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.8719 mL 24.3594 mL 48.7187 mL
    5 mM 0.9744 mL 4.8719 mL 9.7437 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.8719 mL 24.3593 mL 48.7187 mL 121.7967 mL
    5 mM 0.9744 mL 4.8719 mL 9.7437 mL 24.3593 mL
    10 mM 0.4872 mL 2.4359 mL 4.8719 mL 12.1797 mL
    15 mM 0.3248 mL 1.6240 mL 3.2479 mL 8.1198 mL
    20 mM 0.2436 mL 1.2180 mL 2.4359 mL 6.0898 mL
    25 mM 0.1949 mL 0.9744 mL 1.9487 mL 4.8719 mL
    30 mM 0.1624 mL 0.8120 mL 1.6240 mL 4.0599 mL
    40 mM 0.1218 mL 0.6090 mL 1.2180 mL 3.0449 mL
    50 mM 0.0974 mL 0.4872 mL 0.9744 mL 2.4359 mL
    60 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0299 mL
    80 mM 0.0609 mL 0.3045 mL 0.6090 mL 1.5225 mL
    100 mM 0.0487 mL 0.2436 mL 0.4872 mL 1.2180 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Phenformin Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Phenformin114-86-3PhenethylbiguanideApoptosisMitochondrial MetabolismAMPKAMP-activated protein kinasetype 2 diabetes mellitusInhibitorinhibitorinhibit

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