2. NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Keap1-Nrf2 NF-κB Mitochondrial Metabolism Apoptosis
  4. (Rac)-Salvianic acid A sodium

(Rac)-Salvianic acid A sodium  (Synonyms: (Rac)-Danshensu sodium; (Rac)-Tanshinol sodium)

Cat. No.: HY-N0106 Purity: ≥98.0%
SDS COA Handling Instructions

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(Rac)-Salvianic acid A sodium is the racemic form of Salvianic acid A (HY-N1913). Salvianic acid A is an orally active phenolic compound that induces Nrf2/HO-1 activation and inhibits the NF-κB pathway, and it also activates the mitochondrial antioxidant defense system (Mitochondrial Metabolism). Salvianic acid A exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties (Apoptosis), demonstrating potential for research into inflammation and cardiovascular diseases.

For research use only. We do not sell to patients.

(Rac)-Salvianic acid A sodium Chemical Structure

(Rac)-Salvianic acid A sodium Chemical Structure

CAS No. : 67920-52-9

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 61 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-Salvianic acid A sodium:

(Rac)-Salvianic acid A sodium Related Antibodies

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1 Publications Citing Use of MCE (Rac)-Salvianic acid A sodium

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Description

(Rac)-Salvianic acid A sodium is the racemic form of Salvianic acid A (HY-N1913). Salvianic acid A is an orally active phenolic compound that induces Nrf2/HO-1 activation and inhibits the NF-κB pathway, and it also activates the mitochondrial antioxidant defense system (Mitochondrial Metabolism). Salvianic acid A exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties (Apoptosis), demonstrating potential for research into inflammation and cardiovascular diseases[1][2][3][4][5][6][7].

In Vitro

Salvianic acid A (6-36 μM, 24 h) inhibits the decrease in vascular endothelial cell viability induced by Lipopolysaccharide (HY-D1056) in a dose-dependent manner[6].
Salvianic acid A (10 or 20 μM, 24 h) inhibits Lipopolysaccharide (HY-D1056)-induced apoptosis through regulating glutathione peroxidase activity and malondialdehyde level in vascular endothelial cells[6].
Salvianic acid A sodium (25 or 50 μM, 24 h) protects human umbilical vein endothelial cells against tert-butyl hydroperoxide induced oxidative injury via mitochondria-dependent pathway[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-Salvianic acid A sodium Related Antibodies

Cell Viability Assay[6]

Cell Line: Lipopolysaccharide (HY-D1056)-induced human umbilical vein endothelial cells
Concentration: 6-36 μM
Incubation Time: 24 h
Result: Inhibited the decrease in cell viability in a dose-dependent manner.

Apoptosis Analysis[7]

Cell Line: Tert-butyl hydroperoxide induced human umbilical vein endothelial cell
Concentration: 0, 25, 50, 100, 200 μM
Incubation Time: 24 h
Result: Protected HUVEC cells against apoptosis induced by tert-butyl hydroperoxide.

Western Blot Analysis[7]

Cell Line: Tert-butyl hydroperoxide induced human umbilical vein endothelial cell
Concentration: 25 or 50 μM
Incubation Time: 24 h
Result: Reversed the downregulation of MnSOD and Bcl-2 levels and the release of Cyt-c from mitochondria caused by tert-butyl hydroperoxide damage.
In Vivo

Salvianic acid A (3 or 10 mg/kg, p.o., once daily for 6 weeks) suppresses inflammatory reactions and inhibits oxidative stress in atherosclerosis (AS) rats induced by a high-fat diet, showing protective effects against atherosclerosis[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Atherosclerosis (AS) model induced by a high-fat diet in Sprague-Dawley rats (180-220 g)[4]
Dosage: 3 or 10 mg/kg
Administration: Oral gavage (p.o.), once daily for 6 weeks
Result: Inhibited atherosclerotic lesion progression and reduced aortic lipid deposition by 58.2% and 72.8% in high-fat diet-induced AS rats.
Improved lipid profiles by lowering triglyceri/brdes, total cholesterol, and LDL cholesterol while significantly increasing HDL cholesterol in AS rats.
Enhanced antioxidant enzyme activity, upregulated the Nrf2/HO-1 pathway, and reduced the expression of p47phox and p22phox.
Molecular Weight

220.15

Formula

C9H9NaO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(O)C=CC(CC(C(O[Na])=O)O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (454.24 mM; Need ultrasonic)

DMSO : 100 mg/mL (454.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5424 mL 22.7118 mL 45.4236 mL
5 mM 0.9085 mL 4.5424 mL 9.0847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.36 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (11.36 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (227.12 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (247 KB) HNMR (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.5424 mL 22.7118 mL 45.4236 mL 113.5589 mL
5 mM 0.9085 mL 4.5424 mL 9.0847 mL 22.7118 mL
10 mM 0.4542 mL 2.2712 mL 4.5424 mL 11.3559 mL
15 mM 0.3028 mL 1.5141 mL 3.0282 mL 7.5706 mL
20 mM 0.2271 mL 1.1356 mL 2.2712 mL 5.6779 mL
25 mM 0.1817 mL 0.9085 mL 1.8169 mL 4.5424 mL
30 mM 0.1514 mL 0.7571 mL 1.5141 mL 3.7853 mL
40 mM 0.1136 mL 0.5678 mL 1.1356 mL 2.8390 mL
50 mM 0.0908 mL 0.4542 mL 0.9085 mL 2.2712 mL
60 mM 0.0757 mL 0.3785 mL 0.7571 mL 1.8926 mL
80 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4195 mL
100 mM 0.0454 mL 0.2271 mL 0.4542 mL 1.1356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(Rac)-Salvianic acid A sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Salvianic acid A67920-52-9(Rac)-Danshensu(Rac)-TanshinolKeap1-Nrf2NF-κBMitochondrial MetabolismApoptosisNuclear factor-κBNuclear factor-kappaBOrallyHO-1antioxidant defense mechanismanti-oxidationanti-apoptosislung inflammatoryCOVID-19cardiovascularcerebrovascularInhibitorinhibitorinhibit

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