2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. (Rac)-WAY-161503 hydrochloride

(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects.

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(Rac)-WAY-161503 hydrochloride Chemical Structure

(Rac)-WAY-161503 hydrochloride Chemical Structure

CAS No. : 276695-22-8

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(Rac)-WAY-161503 hydrochloride Related Antibodies

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Description

(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects[1][2].

IC50 & Target[1]

5-HT2C Receptor

4 nM (Ki)

5-HT2C Receptor

12 nM (EC50)

In Vivo

(Rac)-WAY-161503 (3-30 mg/kg; i.p.; male C57BL/6J mice) hydrochloride dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Antagonized the PGE2-mediated inhibition of LPS-induced TNF-α release from rat whole blood culture, in a dose-dependent way.
Molecular Weight

308.59

Formula

C11H12Cl3N3O
CAS No.
SMILES

O=C1C(CNCC2)N2C3=C(C=C(Cl)C(Cl)=C3)N1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(Rac)-WAY-161503 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-WAY-161503276695-22-85-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2Cinositolphosphatecalciummobilizationarachidonicacidanti-obesityantidepressantInhibitorinhibitorinhibit

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