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Results for "

α1-adrenergic receptor antagonist

" in MedChemExpress (MCE) Product Catalog:

43

Inhibitors & Agonists

2

Natural
Products

5

Isotope-Labeled Compounds

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101815
    Lidanserin

    ZK-33839

    		 5-HT Receptor Adrenergic Receptor Neurological Disease Endocrinology
    Lidanserin (ZK-33839) acts as a 5-HT2A and α1-adrenergic receptor antagonist.
    Lidanserin
  • HY-121186
    Bevantolol hydrochloride

    		Adrenergic Receptor Calcium Channel Cardiovascular Disease Neurological Disease Metabolic Disease
    Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca 2+ antagonist .
    Bevantolol hydrochloride
  • HY-B0781S
    Promethazine-d4 hydrochloride

    		Histamine Receptor Neurological Disease Endocrinology
    Promethazine-d4 (hydrochloride) is the deuterium labeled Promethazine hydrochloride. Promethazine hydrochloride is the first-generation antihistamine; strong antagonist of the H1 receptor and moderate mACh receptor antagonist, moderate affinity for 5-HT2A, 5-HT2C, D2 and α1-adrenergic receptors.
    Promethazine-d4 hydrochloride
  • HY-118638
    Corynanthine

    		Adrenergic Receptor Neurological Disease
    Corynanthine is a selective α1-adrenergic receptor antagonist. Corynanthine can significantly lower intraocular pressure in rabbits .
    Corynanthine
  • HY-116379
    RS-100329

    		Adrenergic Receptor Metabolic Disease
    RS-100329 is an α1-adrenergic receptor (α1-AR) antagonist that effectively inhibits α1-adrenergic receptor-mediated contractions of lower urinary tract tissues in vitro and in vivo. RS-100329 can be used in the research of symptoms related to benign prostatic hyperplasia .
    RS-100329
  • HY-111188
    A55453

    		Adrenergic Receptor Others
    A55453 is a prazosin analogue and a potent α1-adrenergic antagonist. 125I-A55453 is a high-affinity alpha 1-adrenergic receptor probe .
    A55453
  • HY-U00367
    (4E)-SUN9221

    		Adrenergic Receptor 5-HT Receptor Cardiovascular Disease Endocrinology
    (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.
    (4E)-SUN9221
  • HY-B0532S
    Trifluoperazine-d8

    		Isotope-Labeled Compounds Adrenergic Receptor Dopamine Receptor Influenza Virus Autophagy Neurological Disease Cancer
    Trifluoperazine-d8 is a deuterium labeled Trifluoperazine. Trifluoperazine is an antipsychotic phenothiazine agent and a selective α1-adrenergic receptor antagonist. Trifluoperazine is also a potent dopamine D2 receptor inhibitor [1][2].
    Trifluoperazine-d8
  • HY-111984A
    Quinazosin dihydrochloride

    		Adrenergic Receptor Cardiovascular Disease
    Quinazosin dihydrochloride is an antihypertensive α1-adrenergic receptor antagonist whose activity is associated with inhibition of granulopoiesis, resulting in neutropenia and leukopenia. Quinazosin dihydrochloride exhibits dose-related myelosuppression that is correlated with the duration of suppression .
    Quinazosin dihydrochloride
  • HY-112074A
    Tiamenidine hydrochloride

    HOE 440 hydrochloride

    		 Adrenergic Receptor Cardiovascular Disease
    Tiamenidine hydrochloride (HOE 440 hydrochloride) is a centrally acting α1-adrenergic receptor antagonist with hypotensive activity. Tiamenidine hydrochloride regulates blood pressure levels by binding to α1 receptors. Tiamenidine hydrochloride can be used in the study of hypertension .
    Tiamenidine hydrochloride
  • HY-121186R
    Bevantolol (hydrochloride) (Standard)

    		Adrenergic Receptor Calcium Channel Neurological Disease Metabolic Disease
    Bevantolol (hydrochloride) (Standard) is the analytical standard of Bevantolol (hydrochloride). This product is intended for research and analytical applications. Bevantolol hydrochloride is a selective β1 and α1-adrenergic receptor antagonist with pKi values of 7.83, 6.9 in rat cerebral cortex, respectively. Bevantolol hydrochloride is a potent Ca 2+ antagonist .
    Bevantolol (hydrochloride) (Standard)
  • HY-106617A
    Etoperidone hydrochloride

    		5-HT Receptor Adrenergic Receptor Neurological Disease
    Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .
    Etoperidone hydrochloride
  • HY-106617
    Etoperidone

    		5-HT Receptor Adrenergic Receptor Neurological Disease
    Etoperidone, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .
    Etoperidone
  • HY-12962
    NMDA-IN-1

    		iGluR Neurological Disease
    NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.
    NMDA-IN-1
  • HY-103413
    Eticlopride hydrochloride

    		Dopamine Receptor Neurological Disease
    Eticlopride hydrochloride, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Antipsychotic agent .
    Eticlopride hydrochloride
  • HY-B0532
    Trifluoperazine

    		Dopamine Receptor Adrenergic Receptor P-glycoprotein CaMK Influenza Virus Autophagy Neurological Disease
    Trifluoperazine, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine is a potent α1-adrenergic receptor antagonist. Trifluoperazine is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine can be used for the research of schizophrenia. Trifluoperazine acts as a reversible inhibitor of influenza virus morphogenesis .
    Trifluoperazine
  • HY-B0532A
    Trifluoperazine dihydrochloride
    5+ Cited Publications

    		 Dopamine Receptor Adrenergic Receptor CaMK P-glycoprotein Influenza Virus Autophagy Neurological Disease Cancer
    Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis .
    Trifluoperazine dihydrochloride
  • HY-19686
    Ipsapirone

    TVX Q 7821 free base

    		 5-HT Receptor Neurological Disease
    Ipsapirone (TVX Q 7821) is an anxiolytic compound and a 5-HT1A receptor partial agonist. Ipsapirone (TVX Q 7821) also exhibits 5-HT1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the α1-adrenergic function .
    Ipsapirone
  • HY-19686A
    Ipsapirone hydrochloride

    TVX Q 7821

    		 5-HT Receptor Neurological Disease
    Ipsapirone hydrochloride (TVX Q 7821) is an anxiolytic compound and a 5-HT1A receptor partial agonist. Ipsapirone hydrochloride (TVX Q 7821) also exhibits 5-HT1A receptor antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the α1-adrenergic function .
    Ipsapirone hydrochloride
  • HY-103093
    Zotepine

    		5-HT Receptor Histamine Receptor Adrenergic Receptor Dopamine Receptor Neurological Disease
    Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo .
    Zotepine
  • HY-B0532AS
    Trifluoperazine-d3 dihydrochloride

    		Isotope-Labeled Compounds Dopamine Receptor Adrenergic Receptor CaMK P-glycoprotein Influenza Virus Autophagy Neurological Disease Cancer
    Trifluoperazine-d3 (dihydrochloride) is deuterium labeled Trifluoperazine (dihydrochloride). Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis[1][2][3][4][5].
    Trifluoperazine-d3 dihydrochloride
  • HY-B0532B
    Trifluoperazine dimaleate

    		Dopamine Receptor Adrenergic Receptor P-glycoprotein CaMK Influenza Virus Autophagy Infection Neurological Disease Cancer
    Trifluoperazine dimaleate, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dimaleate is a potent α1-adrenergic receptor antagonist. Trifluoperazine dimaleate is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dimaleate is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dimaleate can be used for the research of schizophrenia. Trifluoperazine dimaleate acts as a reversible inhibitor of influenza virus morphogenesis .
    Trifluoperazine dimaleate
  • HY-10349A
    WAY-100635 maleate
    5+ Cited Publications

    		 5-HT Receptor Dopamine Receptor Neurological Disease
    WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4 receptor agonist .
    WAY-100635 maleate
  • HY-B0532AR
    Trifluoperazine (dihydrochloride) (Standard)

    		Dopamine Receptor Adrenergic Receptor CaMK P-glycoprotein Influenza Virus Autophagy Neurological Disease Cancer
    Trifluoperazine (dihydrochloride) (Standard) is the analytical standard of Trifluoperazine (dihydrochloride). This product is intended for research and analytical applications. Trifluoperazine dihydrochloride, an antipsychotic agent, acts by blocking central dopamine receptors. Trifluoperazine dihydrochloride is a potent α1-adrenergic receptor antagonist. Trifluoperazine dihydrochloride is a potent NUPR1 inhibitor exerting anticancer activity. Trifluoperazine dihydrochloride is a calmodulin inhibitor, and also inhibits P-glycoprotein. Trifluoperazine dihydrochloride can be used for the research of schizophrenia. Trifluoperazine dihydrochloride acts as a reversible inhibitor of influenza virus morphogenesis .
    Trifluoperazine (dihydrochloride) (Standard)
  • HY-B0193A
    Prazosin hydrochloride
    Maximum Cited Publications
    12 Publications Verification

    		 Adrenergic Receptor Autophagy Cardiovascular Disease Endocrinology Cancer
    Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively .
    Prazosin hydrochloride
  • HY-103093R
    Zotepine (Standard)

    		5-HT Receptor Histamine Receptor Adrenergic Receptor Dopamine Receptor Neurological Disease
    Zotepine (Standard) is the analytical standard of Zotepine. This product is intended for research and analytical applications. Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo .
    Zotepine (Standard)
  • HY-10349
    WAY-100635
    5+ Cited Publications

    		 5-HT Receptor Dopamine Receptor Neurological Disease
    WAY-100635 is a potent and selective 5-HT1A Receptor antagonist with a pIC50 of 8.87, an apparent pA2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D4 receptor agonist .
    WAY-100635
  • HY-B0193AR
    Prazosin hydrochloride (Standard)

    		Adrenergic Receptor Autophagy Cardiovascular Disease Endocrinology Cancer
    Prazosin (hydrochloride) (Standard) is the analytical standard of Prazosin (hydrochloride). This product is intended for research and analytical applications. Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders . Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM .Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively .
    Prazosin hydrochloride (Standard)
  • HY-U00110
    MG 1

    		Adrenergic Receptor Cardiovascular Disease Endocrinology
    MG 1 is an α1 adrenergic receptor antagonist.
    MG 1
  • HY-105798
    Butanserin

    R 53393

    		 Adrenergic Receptor Cardiovascular Disease
    Butanserin (R 53393) is a potent and selective α1-adrenoceptor antagonist for the study of cardiovascular disease .
    Butanserin
  • HY-12882
    Ifenprodil

    RC 61-91; NP-120

    		 iGluR Neurological Disease
    Ifenprodil (RC 61-91) is a noncompetitive NMDA receptor antagonist with anti-excitotoxic activity. Ifenprodil significantly improves long-term sensorimotor and spatial learning deficits in mice after acute subarachnoid hemorrhage. Ifenprodil reduces neuronal cell death in the basal cortex and CA1 region of the hippocampus induced by experimental subarachnoid hemorrhage. Ifenprodil attenuates Ca2+ overload in basal cortical cells and mitochondria, as well as brain edema in blood-brain barrier damage and early brain injury. Ifenprodil reduces the intracellular Ca2+ increase and apoptosis of primary cortical neurons under conditions of high glutamate concentrations. Ifenprodil also reduces the increase in endothelial permeability caused by high glutamate concentrations in human brain microvascular endothelial cells. Ifenprodil also inhibits GIRK channels and interacts with α1-adrenergic, 5-HT, and σ receptors .
    Ifenprodil
  • HY-B0192AS1
    Alfuzosin-d7 hydrochloride

    SL 77499-10-d7

    		 Isotope-Labeled Compounds Adrenergic Receptor Endocrinology
    Alfuzosin-d7 (hydrochloride) is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
    Alfuzosin-d7 hydrochloride
  • HY-B0192AS
    Alfuzosin-d3 hydrochloride

    SL 77499-10-d3

    		 Isotope-Labeled Compounds Adrenergic Receptor Endocrinology
    Alfuzosin-d3 hydrochloride is the deuterium labeled Alfuzosin hydrochloride. Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).
    Alfuzosin-d3 hydrochloride
  • HY-101690
    QF0301B

    		Adrenergic Receptor Cardiovascular Disease Endocrinology
    QF0301B is an α1 adrenergic receptor antagonist and a low α2 adrenoceptor, 5-HT2A, and histamine H1 receptor blocker.
    QF0301B
  • HY-12717
    Phentolamine
    4 Publications Verification

    		 Adrenergic Receptor Endocrinology Cancer
    Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction .
    Phentolamine
  • HY-N2037
    Higenamine
    3 Publications Verification

    Norcoclaurine; Demethyl-Coclaurine

    		 MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis Cardiovascular Disease Endocrinology
    Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
    Higenamine
  • HY-100980
    HEAT hydrochloride

    BE2254 hydrochloride

    		 Adrenergic Receptor Neurological Disease Cancer
    HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively .
    HEAT hydrochloride
  • HY-10791
    Ritanserin
    3 Publications Verification

    R 55667

    		 5-HT Receptor Histamine Receptor Dopamine Receptor Adrenergic Receptor Neurological Disease
    Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors .
    Ritanserin
  • HY-12717R
    Phentolamine (Standard)

    		Adrenergic Receptor Endocrinology
    Phentolamine (Standard) is the analytical standard of Phentolamine. This product is intended for research and analytical applications. Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction .
    Phentolamine (Standard)
  • HY-137387
    Carvedilol Glucuronide

    		Drug Metabolite Cardiovascular Disease Others
    Carvedilol Glucuronide is the metabolite of Carvedilol (HY-B0006). Carvedilol (BM 14190) is an antagonist for β/α-1 adrenergic receptor. Carvedilol inhibits lipid peroxidation with an IC50 of 5 μM. Carvedilol is an antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome .
    Carvedilol Glucuronide
  • HY-N0584B
    Anisodamine hydrochloride

    6-Hydroxyhyoscyamine hydrochloride

    		 Adrenergic Receptor Inflammation/Immunology Cancer
    Anisodamine hydrochloride is an anticholinergic and α1 adrenergic receptor antagonist. Anisodamine hydrochloride can be used for improving blood flow in circulatory disorders such as septic shock, Anisodamine hydrochloride displays a spectrum of pharmacological effects similar to Atropine (HY-B1205) and Sopolamine (HY-B2065) including inhibition of salivation, gastrointestinal and sweat secretion, gastrointestinal motility, respiratory secretion and urinary bladder contraction in vivo .
    Anisodamine hydrochloride
  • HY-B1435A
    Moxisylyte

    Thymoxamine

    		 Others Neurological Disease
    Moxisylyte (Thymoxamine) is an alpha 1-selective antagonist with activity that improves bladder emptying. Moxisylyte is used to suppress urinary difficulties in patients with multiple system atrophy (MSA) by blocking alpha 1-adrenergic receptors to reduce the amount of residual urine after urination. Moxisylyte is also used to suppress erectile dysfunction and can improve blood circulation problems caused by Raynaud's syndrome in the short term. In addition, Moxisylyte can be applied topically to the eye to reverse the mydriasis caused by phenylephrine and other sympathetic stimulants .
    Moxisylyte
  • HY-136693
    L-654284

    		Others Neurological Disease
    L-654284 is an α2-adrenergic receptor antagonist with significant selectivity. L-654284 competes with the binding of 3H-clonidine and 3H-rauwolscine in vitro and shows Ki values of 0.8 nM and 1.1 nM, respectively. L-654284 can block the protrusion effect of clonidine in isolated vas deferens in rats, with a pA2 value of 9.1. L-654284 exhibits remarkable selectivity for α2 and α1 adrenergic receptors, and exhibits a Ki of 110 nM in inhibiting 3H-prazosin binding. L-654284 can significantly increase the turnover rate of norepinephrine in rat cerebral cortex in vivo, showing α2-adrenergic receptor blocking activity in the central nervous system .
    L-654284

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