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37

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1

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3

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1

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2

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1

Isotope-Labeled Compounds

1

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5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-141591
    CYT296

    		Others Others
    CYT296 is a target chromatin de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research .
    CYT296
  • HY-B0450
    Ciclopirox
    5+ Cited Publications

    HOE296b

    		 Fungal Bacterial Ferroptosis Autophagy Infection Inflammation/Immunology Cancer
    Ciclopirox (HOE296b) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox also has anticancer and anti-inflammatory effect .
    Ciclopirox
  • HY-134559
    TKIM

    		Potassium Channel Neurological Disease
    TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1 .
    TKIM
  • HY-R00505A
    hsa-miR-296-3p agomir

    		MicroRNA Cancer
    hsa-miR-296-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-296-3p agomir
    hsa-miR-296-3p agomir
  • HY-118269
    OSI-296

    		c-Met/HGFR Cancer
    OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated .
    OSI-296
  • HY-107605
    UBP296

    		iGluR Neurological Disease
    UBP296 is a potent and selective antagonist of GLUK5-containing kainate receptor in the spinal cord. UBP296 reversibly blocks ATPA-induced depressions of synaptic transmission, and affects AMPA receptor-mediated synaptic transmission directly in rat hippocampal slices .
    UBP296
  • HY-106914
    Sinitrodil

    ITF 296

    		 Others Cardiovascular Disease
    Sinitrodil (ITF 296) is an orally active organic nitrate with anti-ischaemic effect. Sinitrodil can be used for acute and chronic heart diseases research .
    Sinitrodil
  • HY-R00505
    hsa-miR-296-3p mimic

    		MicroRNA Cancer
    hsa-miR-296-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    hsa-miR-296-3p mimic
    hsa-miR-296-3p mimic
  • HY-B0450AG
    Ciclopirox olamine

    Ciclopirox ethanolamine; HOE 296

    		 Bacterial Fungal Ferroptosis Infection
    Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .
    Ciclopirox olamine
  • HY-RI00505
    hsa-miR-296-3p inhibitor

    		MicroRNA Cancer
    hsa-miR-296-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    hsa-miR-296-3p inhibitor
    hsa-miR-296-3p inhibitor
  • HY-B0274
    Chlorprothixene

    		Dopamine Receptor Histamine Receptor Bacterial Neurological Disease
    Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .
    Chlorprothixene
  • HY-B0274A
    Chlorprothixene hydrochloride

    		Dopamine Receptor Histamine Receptor Bacterial Neurological Disease
    Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .
    Chlorprothixene hydrochloride
  • HY-RI00505A
    hsa-miR-296-3p antagomir

    		MicroRNA Cancer
    hsa-miR-296-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
    hsa-miR-296-3p antagomir
    hsa-miR-296-3p antagomir
  • HY-B0274R
    Chlorprothixene (Standard)

    		Dopamine Receptor Histamine Receptor Bacterial Neurological Disease
    Chlorprothixene (Standard) is the analytical standard of Chlorprothixene. This product is intended for research and analytical applications. Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .
    Chlorprothixene (Standard)
  • HY-B0274AR
    Chlorprothixene hydrochloride (Standard)

    		Dopamine Receptor Histamine Receptor Bacterial Neurological Disease
    Chlorprothixene (hydrochloride) (Standard) is the analytical standard of Chlorprothixene (hydrochloride). This product is intended for research and analytical applications. Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity .
    Chlorprothixene hydrochloride (Standard)
  • HY-169026
    DCN1-IN-2

    		TGF-beta/Smad Cardiovascular Disease
    DCN1-IN-2 is a DCN1 inhibitor with an IC50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3 .
    DCN1-IN-2
  • HY-Y1311
    Malic acid
    2 Publications Verification

    Hydroxybutanedioic acid; E 296

    		 Endogenous Metabolite Others
    Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.
    Malic acid
  • HY-108035
    (-)-JM-1232

    MR04A3

    		 GABA Receptor Neurological Disease
    (-)-JM-1232 (MR04A3) targets GABA A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA A receptors. (-)-JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI50 values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-)-JM-1232 can be used in research related to pain and analgesia .
    (-)-JM-1232
  • HY-B0450A
    Ciclopirox olamine
    5+ Cited Publications

    Ciclopirox ethanolamine; HOE 296

    		 Fungal Bacterial Ferroptosis Infection Cancer
    Ciclopirox olamine (Ciclopirox ethanolamine) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox olamine also has anticancer and anti-inflammatory effect .
    Ciclopirox olamine
  • HY-19396
    Ingliforib
    1 Publications Verification

    CP 368296; GPi 296

    		 Others Cardiovascular Disease
    Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC50s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.
    Ingliforib
  • HY-W250303
    Malic acid disodium salt

    Hydroxybutanedioic acid disodium salt; E 296 disodium salt

    		 Biochemical Assay Reagents Others
    Sodium DL-Malate is an organic compound commonly used as a food additive, buffer and nutritional supplement. It contains sodium and malic acid. Malic acid disodium salt has several properties suitable for these applications, including the ability to enhance food flavor, improve texture and regulate acidity. Additionally, it can be used as a dietary supplement due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance.
    Malic acid disodium salt
  • HY-Y1069
    (S)-Malic acid
    1 Publications Verification

    (S)-Hydroxybutanedioic acid; (S)-E 296; L-Malic acid

    		 Endogenous Metabolite Metabolic Disease
    (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
    (S)-Malic acid
  • HY-W250303A
    Malic acid disodium hydrate
    2 Publications Verification

    Hydroxybutanedioic acid disodium hydrate; Disodium DL-malate hydrate; E 296 disodium hydrate

    		 Biochemical Assay Reagents Others
    Malic acid disodium hydrate is an organic compound that is commonly used as a food additive, buffering agent, and nutritional supplement. It contains sodium and malic acid. Malic acid disodium hydrate has a variety of properties that make it suitable for these applications, including the ability to enhance food flavor, improve texture, and regulate acidity. In addition, due to its potential health benefits, including improved energy production, reduced fatigue, and enhanced athletic performance, Malic acid disodium hydrate can be used as a dietary supplement .
    Malic acid disodium hydrate
  • HY-104020A
    Philanthotoxin 74 dihydrochloride

    PhTx 74 dihydrochloride

    		 iGluR Neurological Disease
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively .
    Philanthotoxin 74 dihydrochloride
  • HY-104020B
    Philanthotoxin 74 diTFA

    PhTx 74 diTFA

    		 iGluR Neurological Disease
    Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively .
    Philanthotoxin 74 diTFA
  • HY-P10061
    Cathepsin K inhibitor 4

    		Cathepsin Cancer
    Cathepsin K inhibitor 4 is a potent carbohydrazide Cathepsin K inhibitor with IC50s of 13 nM, 269 nM, 296 nM for human, rat, mouse Cathepsin K, respectively .
    Cathepsin K inhibitor 4
  • HY-101979A
    Numidargistat dihydrochloride
    Maximum Cited Publications
    7 Publications Verification

    CB-1158 dihydrochloride; INCB01158 dihydrochloride

    		 Arginase Cancer
    Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent .
    Numidargistat dihydrochloride
  • HY-101979
    Numidargistat
    Maximum Cited Publications
    7 Publications Verification

    CB-1158; INCB01158

    		 Arginase Cancer
    Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent .
    Numidargistat
  • HY-113723
    MRS2298

    		P2Y Receptor Cardiovascular Disease
    MRS2298? is a potent acyclic P2Y1 receptor antagonist with a Ki of 29.6 nM. MRS2298 inhibits the ADP-induced aggregation of human platelets with an IC50 of 62.8 nM. MRS2298 inhibits Ca 2+ rise in platelets with an IC50 of 810 nM .
    MRS2298
  • HY-152104
    FGFR-IN-9

    		FGFR Cancer
    FGFR-IN-9 (Compound 19) is a potent, reversible and orally active FGFR inhibitor with an IC50 of 17.1, 29.6, 30.7, 46.7 and 64.3 nM against FGFR4 WT, FGFR3, FGFR4 V550L, FGFR2 and FGFR1, respectively .
    FGFR-IN-9
  • HY-12294
    PEAQX

    NVP-AAM077

    		 Caspase Apoptosis iGluR Neurological Disease
    PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures .
    PEAQX
  • HY-117782
    Anticancer agent 236

    		Others Cancer
    Anticancer agent 236 (compound JP-8g) is a broad-spectrum anticancer agent that has toxic effects on several cancer cell lines with IC50 values of 6.925 μM (MDA), 6.296 μM (U937), 6.548 μM (Jurkat), 6.373 μM (Hela), and 10.381 μM (EJ) .
    Anticancer agent 236
  • HY-B0450R
    Ciclopirox (Standard)

    		Fungal Bacterial Ferroptosis Autophagy Infection Inflammation/Immunology Cancer
    Ciclopirox (Standard) is the analytical standard of Ciclopirox. This product is intended for research and analytical applications. Ciclopirox (HOE296b) is a synthetic and orally active antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic. Ciclopirox also has anticancer and anti-inflammatory effect .
    Ciclopirox (Standard)
  • HY-12294A
    PEAQX tetrasodium hydrate
    5 Publications Verification

    NVP-AAM077 tetrasodium hydrate

    		 Apoptosis Caspase iGluR Neurological Disease
    PEAQX tetrasodium hydrate (NVP-AAM077 tetrasodium hydrate) is a tetrasodium hydrate of PEAQX (HY-12294). PEAQX tetrasodium hydrate is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX tetrasodium hydrate can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures .
    PEAQX tetrasodium hydrate
  • HY-162464
    MPD2

    		PROTACs SARS-CoV Infection
    MPD2 is a Cereblon-binding ligand-based PROTAC that degrades MPro, the main protease of SARS-CoV-2. MPD2 effectively reduced MPro protein levels in 293T cells in a time-dependent manner (DC50=296 nM). MPD2 exhibited potent antiviral activity against multiple SARS-CoV-2 strains and had enhanced potency against Nirmatrelvir (HY-138687) resistant strains. MPD2 provides a new direction for antiviral drug development against SARS-CoV-2 and other emerging coronavirus pathogens (Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker (HY-W275882)；Red: SARS-CoV-2 MPro Inhibitor MP18 (HY-158763)) .
    MPD2
  • HY-Y1069S3
    (S)-Malic acid-13C4

    (S)-Hydroxybutanedioic acid-13C4; (S)-E 296-13C4; L-Malic acid-13C4

    		 Isotope-Labeled Compounds Others
    (S)-Malic acid- 13C4 is the 13C labeled S-Malic acid (HY-Y1069)[1].
    (S)-Malic acid-13C4
  • HY-145258
    GABAA receptor agent 6

    		GABA Receptor Neurological Disease
    GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 µM. GABAA receptor agent 6 shows γ-GABAAR antagonist activity with low cellular membrane permeability .
    GABAA receptor agent 6

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