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Results for "

405 nm

" in MedChemExpress (MCE) Product Catalog:

34

Inhibitors & Agonists

11

Fluorescent Dye

4

Biochemical Assay Reagents

8

Peptides

1

Inhibitory Antibodies

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-116022A
    4-Nitrophenyl phosphate disodium hexahydrate
    3 Publications Verification

    p-Nitrophenyl phosphate disodium hexahydrate

    		 Biochemical Assay Reagents Others
    4-Nitrophenyl phosphate (p-nitrophenyl phosphate) disodium hexahydrate is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. 4-Nitrophenyl phosphate disodium hexahydrate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .
    4-Nitrophenyl phosphate disodium hexahydrate
  • HY-12481A
    SAR405 R enantiomer

    		Others Cancer
    SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is a PIK3C3/Vps34 inhibitor.
    SAR405 R enantiomer
  • HY-103238
    RSVA405

    		AMPK STAT Autophagy Neurological Disease Metabolic Disease Inflammation/Immunology
    RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity .
    RSVA405
  • HY-D1809
    Vari Fluor 405-Streptavidin

    		Fluorescent Dye Others
    Vari Fluor 405-Streptavidin is a dye marker of Vari Fluor-streptavidin consisting of labeling streptavidin with a Vari Fluor series of fluorescent probes. Streptavidin is a high-affinity tetramer protein, each tetramer consisting of four identical streptavidin subunits. Streptavidin binds to biotin specifically via a reversible non-covalent effect. Streptavidin can achieve rapid and efficient detection of biotin markers, and is often used in immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), immunohistochemical staining (IFH), in situ hybridization (ISH) and other experiments. Ex/Em=405 nm/431 nm.
    Vari Fluor 405-Streptavidin
  • HY-116022
    4-Nitrophenyl phosphate

    p-Nitrophenyl phosphate

    		 Biochemical Assay Reagents Others
    4-Nitrophenyl phosphate (p-Nitrophenyl phosphate) is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases.4-Nitrophenyl phosphate is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm .
    4-Nitrophenyl phosphate
  • HY-W250172
    Triton X-405

    		Biochemical Assay Reagents Others
    Triton X-405 is a nonionic surfactant commonly used in a variety of industrial and research applications. Triton X-405 belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in emulsions, detergents and solubilizers. Triton X-405 is particularly useful in the study of membrane proteins, where it is used to solubilize and stabilize proteins for structural analysis techniques. It is also used in a variety of other applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Additionally, Triton X-405 is used in the production of microemulsions, salves and lotions due to its emulsifying and solubilizing properties. However, it can be toxic if ingested or inhaled, so proper handling and safety precautions are required.
    Triton X-405
  • HY-D0745
    Acid red 405

    		Fluorescent Dye
    Acid red 405 is an acid dye that can be decolorized when aluminum sulfate is used as a coagulant.
    Acid red 405
  • HY-133532
    PB succiniMidyl ester

    Ocean Blue, SE

    		 Fluorescent Dye Others
    PB succiniMidyl ester (Ocean Blue, SE) is a fluorophore with the λexcitation/emission of ~405/455 nm .
    PB succiniMidyl ester
  • HY-D2299
    AIE-ER

    		Fluorescent Dye Metabolic Disease Cancer
    AIE-ER is a specific endoplasmic reticulum (ER) fluorescent probe (green channel: λex=405 nm, λem=450~650 nm) that exhibits remarkable photostability, high brightness, and low working concentration. AIE-ER may provide an avenue for studying diseases related to the endoplasmic reticulum .
    AIE-ER
  • HY-P10094
    β-Ala-Gly-Arg-pNA

    		Fluorescent Dye Others
    β-Ala-Gly-Arg-pNA is a chromogenic substrate of thrombin with pNA a strong absorbance at 405 nm .
    β-Ala-Gly-Arg-pNA
  • HY-12481
    SAR405
    Maximum Cited Publications
    19 Publications Verification

    		 PI3K Autophagy Cancer
    SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity .
    SAR405
  • HY-133534
    PA-Nic TFA

    		Others Others
    PA-Nic TFA is a photoactivatable nicotine, whcih can be photolyzed with ~405 nm laser flashes to efficiently release nicotine .
    PA-Nic TFA
  • HY-D1794
    Vari Fluor 405 SE

    VF 405 SE

    		 Fluorescent Dye Others
    Vari Fluor 405 SE (VF 405 SE) is a dye marker of the Vari Fluor SE series (Ex/Em=399 nm/421 nm). The Vari Fluor SE series of dyes are a class of fluorescent dyes containing NHS ester groups used to label free amines (-NHX) on antibodies, proteins, peptides, amine-modified oligonucleotides and other biomolecules.
    Vari Fluor 405 SE
  • HY-132850
    Dazcapistat

    BLD-2660

    		 Proteasome Inflammation/Immunology
    Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively (patent WO2018064119A1, compound 405) .
    Dazcapistat
  • HY-W039519
    7-Methoxycoumarin-3-carboxylic acid

    		Fluorescent Dye Cancer
    7-Methoxycoumarin-3-carboxylic acid is a fluorescent dye with an excitation peak at 355 nm and an emission peak at 405 nm. 7-Methoxycoumarin-3-carboxylic acid can be used to label peptide .
    7-Methoxycoumarin-3-carboxylic acid
  • HY-161093
    PROTAC BRD4 Degrader-23

    		PROTACs Cancer
    PROTAC BRD4 Degrader-23 (compound 17) is an effective visible-light-controlled degrader. PROTAC BRD4 Degrader-23 can inhibit tumor cell proliferation under 405 nm light irradiation .
    PROTAC BRD4 Degrader-23
  • HY-163873
    PROTAC SMARCA2/4-degrader-20

    		PROTACs Epigenetic Reader Domain Cancer
    PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades SMARCA2 in A549 and MV411 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 of 100-500 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-163932))
    PROTAC SMARCA2/4-degrader-20
  • HY-121694
    CENTA

    		Others Infection
    CENTA is a colorimetric cephalosporin substrate for β-lactamases. Upon hydrolysis by β-lacatamases, CENTA turns from light yellow to chrome yellow, which can be quantified by colorimetric detection at 405 nm as a measure of β-lactamase activity.
    CENTA
  • HY-131063
    CDK6/9-IN-1

    		CDK Cancer
    CDK6/9-IN-1 (compound 66) is an orally active active and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively .
    CDK6/9-IN-1
  • HY-127140
    Cardanol triene

    		Others Infection
    Cardanol triene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 40.5 μM in vitro. A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.
    Cardanol triene
  • HY-153102
    G3-CNP

    		Biochemical Assay Reagents Others
    G3-CNP is an α-amylase substrate. The absorbance of G3-CNP cleavage product 2-chloro-4-nitrophenol is measured at 405 nm, which can be used to detect enzyme activity .
    G3-CNP
  • HY-131409
    D-Val-Leu-Lys-pNA dihydrochloride

    D-Val-Leu-Lys-p-itoailide dihydrochloride; D-VLK-pNA dihydrochloride; S 2251 dihydrochloride

    		 Fluorescent Dye Others
    D-Val-Leu-Lys-pNA dihydrochloride (D-VLK-pNA dihydrochloride) is a colorimetric substrate for plasminolytic activity. D-Val-Leu-Lys-pNA dihydrochloride is catalytically bound and hydrolyzed by plasmin to release p-nitroaniline (pNA), which can be detected colorimetrically at 405 nm as a measure of plasminolytic activity .
    D-Val-Leu-Lys-pNA dihydrochloride
  • HY-D2297
    AIE-GA

    		Fluorescent Dye Others
    AIE-GA is a Golgi apparatus (GA) fluorescent probe (green channel: λex = 405 nm, λem = 500-700 nm). AIE-GA has a favourable binding ability to interact with COX-2. AIE-GA binds to the cyclooxygenase catalytic site of COX-2 .
    AIE-GA
  • HY-120833
    Ac-Ile-Glu-Thr-Asp-pNA

    		Caspase Others
    Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
    Ac-Ile-Glu-Thr-Asp-pNA
  • HY-137858
    H-Gly-Arg-pNA hydrochloride

    Gly-Arg-4-NA hydrochloride; GR-pNA hydrochloride; GR p-itoailide hydrochloride

    		 Fluorescent Dye Others
    H-Gly-Arg-pNA hydrochloride (GR-pNA hydrochloride) is a colorimetric substrate for thrombin. H-Gly-Arg-pNA is preferentially bound by thrombin and cleaves the Gly-Arg (GR) peptide sequence, releasing p-nitroaniline (pNA) that can be detected colorimetrically at 405 nm. H-Gly-Arg-pNA hydrochloride is used as a fluorescent dye to measure thrombin activity .
    H-Gly-Arg-pNA hydrochloride
  • HY-137798
    Chromozym PL

    		Fluorescent Dye Others
    Chromozym PL is a chromogenic substrate for plasmin, and the enzymatic reaction can be carried out in 0.1mL Tris-HCl buffer (50 mM, pH 7.8). 100 μM Chromozym PL was dissolved and prepared. After adding the hydrolase, the generation of p-nitroaniline (pNA) at 405 nm was continuously observed, and the hydrolysis products were calculated .
    Chromozym PL
  • HY-131019
    JF-NP-26

    		mGluR Neurological Disease
    JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals .
    JF-NP-26
  • HY-124324
    4-Nitrophenyl β-D-cellotrioside

    p-Nitopheyl β-D-cellotioside

    		 Fluorescent Dye Others
    4-Nitrophenyl β-D-cellotrioside (p-Nitopheyl β-D-cellotioside) is a chromogenic substrate for endoglucanases and cellulose biohydrolases. As a fluorescent dye, nitrophenyl β-D-Cellotrioside can be hydrolyzed by enzymes to release 4-nitrophenol, producing a yellow color. The activity of the enzyme can be quantitatively analyzed by monitoring the change in absorbance at 405 nm .
    4-Nitrophenyl β-D-cellotrioside
  • HY-D1571
    CellTracker Blue CMF2HC Dye

    		DNA Stain Others
    CellTracker Blue CMF2HC Dye is a blue dye, can be used in two-channel nuclei acid sequencing, with blue and purple excitation light (450-460 nm/400-405nm or 415-450 nm/480-525nm). CellTracker Blue CMF2HC Dye can be used to rapid determination of antibiotic sensitivity of microorganisms .
    CellTracker Blue CMF2HC Dye
  • HY-144315
    CYD19

    Snail/HDAC-IN-1

    		 HDAC Cancer
    CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis .
    CYD19
  • HY-P10007
    Z-Gly-Pro-Phe-Leu-CHO

    Z-GPFL-CHO

    		 Proteasome Cancer
    Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (Ki = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC50 = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity) .
    Z-Gly-Pro-Phe-Leu-CHO
  • HY-161628
    Tapcin

    		Topoisomerase Cancer
    Tapcin is a dual inhibitor for topoisomerase I and topoisomerase II, with IC50 of 203 and 71 nM. Tapcin inhibits proliferations of cancer cells A-375, HeLa, Huh7.5, U2-OS, A549, Caco-2 and HT29, with IC50s of 441, 1.04, 40.5, 0.002, 0.006, 0.287 and 0.842 nM, respectively. Tapcin exhibits antitumor activity in HT29 xenograft model .
    Tapcin
  • HY-123704
    CGS-12066 maleate

    		5-HT Receptor Neurological Disease
    CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT1A , 5-HT1B ,5-HT1C and 5-HT1D with pEC50 values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease .
    CGS-12066 maleate
  • HY-B1247
    Protoporphyrin IX
    10+ Cited Publications

    		 Endogenous Metabolite Others
    Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma .
    Protoporphyrin IX

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