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APC

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64

Inhibitors & Agonists

6

Fluorescent Dye

3

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6

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2

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1

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11

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11

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100620

    APC

    Topoisomerase Cholinesterase (ChE) Cancer
    RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE .
    RPR121056
  • HY-105999

    Ser/Thr Protease Inflammation/Immunology
    APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .
    APC 366
  • HY-114015

    Ser/Thr Protease Cancer
    APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer .
    APC-6860
  • HY-105999A

    Ser/Thr Protease Inflammation/Immunology
    APC 366 hydrochloride is a selective inhibitor of mast cell trypsin activity. APC 366 hydrochloride is able to inhibit trypsin-induced histamine release in human tonsil and lung cells. APC 366 hydrochloride may have important applications in regulating allergic reactions and inflammation .
    APC 366 hydrochloride
  • HY-105999B

    Protease Activated Receptor (PAR) Others
    APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases .
    APC 366 TFA
  • HY-124445

    NF-κB Inflammation/Immunology
    APC0576 is an inhibitor for the activation of NF-κB signaling pathway, and inhibits the activation of NF-κB depedent gene (IC50 is 1.0 μM for β-gal). APC0576 inhibits IL-1-induced chemokines release, and can be used in research about pathological endothelial cell activation releted diseases .
    APC0576
  • HY-RS00808

    Small Interfering RNA (siRNA) Others

    Apc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Apc Mouse Pre-designed siRNA Set A
    Apc Mouse Pre-designed siRNA Set A
  • HY-RS00809

    Small Interfering RNA (siRNA) Others

    Apc Rat Pre-designed siRNA Set A contains three designed siRNAs for Apc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Apc Rat Pre-designed siRNA Set A
    Apc Rat Pre-designed siRNA Set A
  • HY-RS00807

    Small Interfering RNA (siRNA) Others

    APC Human Pre-designed siRNA Set A contains three designed siRNAs for APC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    APC Human Pre-designed siRNA Set A
    APC Human Pre-designed siRNA Set A
  • HY-RS00810

    Small Interfering RNA (siRNA) Others

    APC2 Human Pre-designed siRNA Set A contains three designed siRNAs for APC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    APC2 Human Pre-designed siRNA Set A
    APC2 Human Pre-designed siRNA Set A
  • HY-D1815
    Allophycocyanin
    1 Publications Verification

    APC Dye

    Fluorescent Dye Others
    Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .
    Allophycocyanin
  • HY-W614725

    APC Ligands for Target Protein for PROTAC Cancer
    Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A monohydrochloride interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A monohydrochloride can be used to synthesize the PROTAC CP5V (HY-130257) .
    Apcin-A monohydrochloride
  • HY-100620R

    APC (Standard)

    Drug Metabolite Reference Standards Topoisomerase Cholinesterase (ChE) Cancer
    RPR121056 (Standard) is the analytical standard of RPR121056. This product is intended for research and analytical applications. RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE[1].
    RPR121056 (Standard)
  • HY-RS16390

    Small Interfering RNA (siRNA) Others

    APCS Human Pre-designed siRNA Set A contains three designed siRNAs for APCS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    APCS Human Pre-designed siRNA Set A
    APCS Human Pre-designed siRNA Set A
  • HY-RS20692

    Small Interfering RNA (siRNA) Others

    Apcs Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apcs gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Apcs Mouse Pre-designed siRNA Set A
    Apcs Mouse Pre-designed siRNA Set A
  • HY-RS27203

    Small Interfering RNA (siRNA) Others
    Apcs Rat Pre-designed siRNA Set A contains three designed siRNAs for Apcs gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Apcs Rat Pre-designed siRNA Set A
    Apcs Rat Pre-designed siRNA Set A
  • HY-153542

    PKG Others
    AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition .
    AP-C6
  • HY-153540

    PKG Others
    AP-C4 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 5.2. AP-C3 does not inhibit cGKII-dependent anion secretion .
    AP-C4
  • HY-153541

    PKG Others
    AP-C7 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 5.0. AP-C7 only weakly inhibits cGKII-dependent anion secretion .
    AP-C7
  • HY-153539

    PKG Others
    AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 6.3. AP-C3 only weakly inhibits cGKII-dependent anion secretion .
    AP-C3
  • HY-153537

    PKG Others
    AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion .
    AP-C1
  • HY-110287
    Apcin
    Maximum Cited Publications
    6 Publications Verification

    APC Mitosis Cancer
    Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .
    Apcin
  • HY-130530

    Biochemical Assay Reagents Metabolic Disease
    AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    AP-C5
  • HY-153538

    Ser/Thr Protease Metabolic Disease
    AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 .
    AP-C2
  • HY-130841

    APC Ligands for Target Protein for PROTAC Cancer
    Apcin-A is a small molecule inhibitor that selectively targets the cell division cycle protein Cdc20 and is a derivative of Apcin (HY-110287). Apcin-A competitively binds to the D-box binding pocket of Cdc20 and inhibits substrate ubiquitination mediated by the anaphase promoting complex APC/C-Cdc20. Apcin-A also blocks the binding of Cdc20 to substrates (such as securin and cyclin B1), inhibiting anaphase initiation and cell cycle exit. Apcin-A can promote or prolong mitotic slippage in coordination with p31 comet under conditions of high spindle assembly checkpoint (SAC) activity. Apcin-A can be used to develop anti-mitotic drugs and overcome tumor chemotherapy resistance. Apcin-A can be used to synthesize PROTAC CP5V (HY-130257)[1][2][3].
    Apcin-A
  • HY-NP053

    OVA-APC

    Biochemical Assay Reagents Others
    Ovalbumin-APC (OVA-APC) is a kind of biological materials or organic compounds that are widely used in life science research .
    Ovalbumin-APC
  • HY-138064

    Biochemical Assay Reagents Others
    4-APC hydrobromide is a highly sensitive and selective derivatization agent for aldehydes. 4-APC hydrobromide possesses an aniline moiety for a fast selective reaction with aliphatic aldehydes as well as a quaternary ammonium group for improved MS sensitivity. 4-APC hydrobromide allows highly sensitive and selective MS detection of aldehydes .
    4-APC hydrobromide
  • HY-NP039

    BSA-APC

    Biochemical Assay Reagents Others
    Bovine Sermu Albumin-APC (BSA-APC) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
    Bovine Serum Albumin-APC
  • HY-P2269A

    Drug Derivative Cancer
    MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 acetate binds APC-ARM with a Ki value of 0.015 μM and aKd value of 0.036 μM. MAIT-203 acetate significantly represses the migration and invasion of colorectal cancer cells .
    MAIT-203 acetate
  • HY-D2180

    Fluorescent Dye Others
    Preactivated APC-Cy5.5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.
    Preactivated APC-Cy5.5 Maleimide
  • HY-P2269

    Drug Derivative Cancer
    MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a Ki of 0.015 μM and a Kd of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.
    MAIT-203
  • HY-108442
    JW67
    1 Publications Verification

    Wnt Cancer
    JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM . JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth .
    JW67
  • HY-101092
    QS-21
    4 Publications Verification

    Stimulon

    NOD-like Receptor (NLR) Inflammation/Immunology Cancer
    QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .
    QS-21
  • HY-13255A
    TAME hydrochloride
    1 Publications Verification

    APC Cancer
    TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable .
    TAME hydrochloride
  • HY-13255
    TAME
    1 Publications Verification

    APC Cancer
    TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable .
    TAME
  • HY-103255

    Apoptosis Cancer
    CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells .
    CFM-4
  • HY-119331

    Apoptosis Cancer
    CFM-5 inhibits CARP-1/CCAR1-APC-2 interaction with an IC50 value of 0.75 μM. CFM-5 inhibits medulloblastoma (MB) cell proliferation and induces apoptosis .
    CFM-5
  • HY-D2182

    Fluorescent Dye Others
    Preactivated PE-Cy5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.
    Preactivated PE-Cy5 Maleimide
  • HY-116572

    Reactive Oxygen Species (ROS) JNK Apoptosis Caspase Cancer
    TASIN-1 hydrochloride is a selective inhibitor of truncated APC TR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 hydrochloride specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 hydrochloride exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 hydrochloride can be used to prevent and intervene in APC mutant colorectal cancer .
    TASIN-1 hydrochloride
  • HY-116572A

    Reactive Oxygen Species (ROS) JNK Apoptosis Caspase Cancer
    TASIN-1 is a selective inhibitor of truncated APC TR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 can be used to prevent and intervene in APC mutant colorectal cancer .
    TASIN-1
  • HY-D2397

    CL-APC

    Fluorescent Dye Others
    Cross-Linked Allophycocyanin is a trimer biliprotein with maximum absorption at 650 nm .
    Cross-Linked Allophycocyanin
  • HY-116473

    APC Cancer
    CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC50 value of 4.1 μM. CFM-1 induces G2M cell cycle arrest and suppresses viabilities of human breast cancer cells .
    CFM-1
  • HY-P0021A

    Spectrozyme PCa; Chromozym Pca diacetate

    Fluorescent Dye Others
    D-Lys(Z)-Pro-Arg-pNA diacetate is a chromogenic peptide substrate of activated protein C (APC) .
    D-Lys(Z)-Pro-Arg-pNA diacetate
  • HY-164467

    Wnt Cancer
    CCT070535 blocks TCF-dependent transcription at the TCF level, with GI50 values of 17.6 μM, 11.1 μM, 11.8 μM and 13.4 μM in HT29 (APC mutant), HCT116 (oncogenic β-catenin), SW480 (APC mutant) and SNU475 (Axin mutant) cells, respectively .
    CCT070535
  • HY-P0021

    Chromozym Pca

    Fluorescent Dye Others
    D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a chromogenic peptide substrate of activated protein C (APC) .
    D-Lys(Z)-Pro-Arg-pNA
  • HY-124955
    proTAME
    5 Publications Verification

    APC Cancer
    proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase .
    proTAME
  • HY-P1918
    Activated Protein C (390-404), human
    4 Publications Verification

    Ser/Thr Protease Cardiovascular Disease
    Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .
    Activated Protein C (390-404), human
  • HY-P1918A

    APC Cardiovascular Disease
    Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .
    Activated Protein C (390-404), human TFA
  • HY-112968

    APC Cardiovascular Disease
    Human Protein C is activated by α-thrombin or α-thrombin/thrombomodulin complex to a serine protease, namely activated protein C (APC). Human Protein C can selectively inactivate factors Va and VIIIa and is a potent anticoagulant .
    Human protein C
  • HY-112968A

    APC Cardiovascular Disease
    Bovine Protein C is activated by α-thrombin or α-thrombin/thrombomodulin complex to a serine protease, namely activated protein C (APC). Bovine Protein C can selectively inactivate factors Va and VIIIa and is a potent anticoagulant .
    Bovine Protein C

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