Search Result

Results for "

APC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	APC (10) Apoptosis (4) Biochemical Assay Reagents (5) Caspase (2) Cholinesterase (ChE) (2) Complement System (1) Drug Derivative (2) Drug Metabolite (1) Fluorescent Dye (6) JNK (2) Ligands for Target Protein for PROTAC (2) Liposome (2) Mitosis (1) NF-κB (1) NOD-like Receptor (NLR) (1) PARP (1) PKG (5) Protease Activated Receptor (PAR) (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) Ser/Thr Protease (5) Small Interfering RNA (siRNA) (8) Toll-like Receptor (TLR) (5) Topoisomerase (2) Wnt (2)
By Research Areas:	Cancer (23) Cardiovascular Disease (4) Inflammation/Immunology (13) Metabolic Disease (2)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Adjuvant (8) Cationic Lipids (1) Human Pre-designed siRNA Sets (4) siRNAs (8)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: APC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100620

RPR121056 APC	Topoisomerase Cholinesterase (ChE)	Cancer
RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE .

HY-105999

APC 366	Ser/Thr Protease	Inflammation/Immunology
APC 366 is a selective inhibitor of mast cell tryptase (K_i=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .

HY-114015

APC-6860	Ser/Thr Protease	Cancer
APC-6860 is a trypsin-like serine proteases inhibitor with k_i values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k_i values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer .

HY-105999A

APC 366 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
APC 366 hydrochloride is a selective inhibitor of mast cell trypsin activity. APC 366 hydrochloride is able to inhibit trypsin-induced histamine release in human tonsil and lung cells. APC 366 hydrochloride may have important applications in regulating allergic reactions and inflammation .

HY-105999B

APC 366 TFA	Protease Activated Receptor (PAR)	Others
APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases .

HY-124445

APC0576	NF-κB	Inflammation/Immunology
APC0576 is an inhibitor for the activation of NF-κB signaling pathway, and inhibits the activation of NF-κB depedent gene (IC₅₀ is 1.0 μM for β-gal). APC0576 inhibits IL-1-induced chemokines release, and can be used in research about pathological endothelial cell activation releted diseases .

HY-RS00808

Apc Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apc Mouse Pre-designed siRNA Set A Apc Mouse Pre-designed siRNA Set A

HY-RS00809

Apc Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apc Rat Pre-designed siRNA Set A contains three designed siRNAs for Apc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apc Rat Pre-designed siRNA Set A Apc Rat Pre-designed siRNA Set A

HY-RS00807

APC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APC Human Pre-designed siRNA Set A contains three designed siRNAs for APC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APC Human Pre-designed siRNA Set A APC Human Pre-designed siRNA Set A

HY-RS00810

APC2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APC2 Human Pre-designed siRNA Set A contains three designed siRNAs for APC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APC2 Human Pre-designed siRNA Set A APC2 Human Pre-designed siRNA Set A

HY-D1815

Allophycocyanin 1 Publications Verification APC Dye	Fluorescent Dye	Others
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .

HY-W614725

Apcin-A monohydrochloride	APC Ligands for Target Protein for PROTAC	Cancer
Apcin-A monohydrochloride, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor. Apcin-A monohydrochloride interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A monohydrochloride can be used to synthesize the PROTAC CP5V (HY-130257) .

HY-100620R

RPR121056 (Standard) APC (Standard)	Drug Metabolite Reference Standards Topoisomerase Cholinesterase (ChE)	Cancer
RPR121056 (Standard) is the analytical standard of RPR121056. This product is intended for research and analytical applications. RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE[1].

HY-RS16390

APCS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APCS Human Pre-designed siRNA Set A contains three designed siRNAs for APCS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APCS Human Pre-designed siRNA Set A APCS Human Pre-designed siRNA Set A

HY-RS20692

Apcs Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apcs Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apcs gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apcs Mouse Pre-designed siRNA Set A Apcs Mouse Pre-designed siRNA Set A

HY-RS27203

Apcs Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apcs Rat Pre-designed siRNA Set A contains three designed siRNAs for Apcs gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apcs Rat Pre-designed siRNA Set A Apcs Rat Pre-designed siRNA Set A

HY-153542

AP-C6	PKG	Others
AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition .

HY-153540

AP-C4	PKG	Others
AP-C4 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.2. AP-C3 does not inhibit cGKII-dependent anion secretion .

HY-153541

AP-C7	PKG	Others
AP-C7 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.0. AP-C7 only weakly inhibits cGKII-dependent anion secretion .

HY-153539

AP-C3	PKG	Others
AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.3. AP-C3 only weakly inhibits cGKII-dependent anion secretion .

HY-153537

AP-C1	PKG	Others
AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion .

HY-110287

Apcin Maximum Cited Publications 7 Publications Verification	APC Mitosis	Cancer
Apcin, a ligand of Cdc20, is a potent and competitive anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity inhibitor. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. Apcin occupes the D-box-binding pocket on the side face of the WD40-domain and can prolong mitosis .

HY-130530

AP-C5	Biochemical Assay Reagents	Metabolic Disease
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-153538

AP-C2	Ser/Thr Protease	Metabolic Disease
AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC₅₀ of 5.2 .

HY-130841

Apcin-A	APC Ligands for Target Protein for PROTAC	Cancer
Apcin-A is a small molecule inhibitor that selectively targets the cell division cycle protein Cdc20 and is a derivative of Apcin (HY-110287). Apcin-A competitively binds to the D-box binding pocket of Cdc20 and inhibits substrate ubiquitination mediated by the anaphase promoting complex APC/C-Cdc20. Apcin-A also blocks the binding of Cdc20 to substrates (such as securin and cyclin B1), inhibiting anaphase initiation and cell cycle exit. Apcin-A can promote or prolong mitotic slippage in coordination with p31 ^comet under conditions of high spindle assembly checkpoint (SAC) activity. Apcin-A can be used to develop anti-mitotic drugs and overcome tumor chemotherapy resistance. Apcin-A can be used to synthesize PROTAC CP5V (HY-130257)[1][2][3].

HY-NP053

Ovalbumin-APC OVA-APC	Biochemical Assay Reagents	Others
Ovalbumin-APC (OVA-APC) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-138064

*4-APC* hydrobromide**	Biochemical Assay Reagents	Others
4-APC hydrobromide is a highly sensitive and selective derivatization agent for aldehydes. 4-APC hydrobromide possesses an aniline moiety for a fast selective reaction with aliphatic aldehydes as well as a quaternary ammonium group for improved MS sensitivity. 4-APC hydrobromide allows highly sensitive and selective MS detection of aldehydes .

HY-NP039

Bovine Serum Albumin-APC BSA-APC	Biochemical Assay Reagents	Others
Bovine Sermu Albumin-APC (BSA-APC) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-P2269A

MAIT-203 acetate	Drug Derivative	Cancer
MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 acetate binds APC-ARM with a K_i value of 0.015 μM and aK_d value of 0.036 μM. MAIT-203 acetate significantly represses the migration and invasion of colorectal cancer cells .

HY-D2180

*Preactivated APC-Cy5.5 Maleimide*	Fluorescent Dye	Others
Preactivated APC-Cy5.5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.

HY-P2269

MAIT-203	Drug Derivative	Cancer
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a K_i of 0.015 μM and a K_d of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.

HY-108442

JW67 1 Publications Verification	Wnt	Cancer
JW67 inhibits the canonical Wnt signaling with an IC₅₀ of 1.17μM . JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth .

HY-101092

QS-21 5 Publications Verification Stimulon	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18 .

HY-13255A

TAME hydrochloride 1 Publications Verification	APC	Cancer
TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable .

HY-13255

TAME 1 Publications Verification	APC	Cancer
TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable .

HY-103255

CFM-4	Apoptosis	Cancer
CFM-4 is a potent small molecular antagonist of CARP-1/APC-2 binding. CFM-4 prevents CARP-1 binding with APC-2, causes G₂M cell cycle arrest, and induces apoptosis with an IC₅₀ range of 10-15 μM. CFM-4 also suppresses growth of drug-resistant human breast cancer cells .

HY-119331

CFM-5	Apoptosis	Cancer
CFM-5 inhibits *CARP-1/CCAR1-APC-2* interaction with an IC₅₀ value of 0.75 μM. CFM-5 inhibits medulloblastoma (MB) cell proliferation and induces apoptosis .

HY-D2182

Preactivated PE-Cy5 Maleimide	Fluorescent Dye	Others
Preactivated PE-Cy5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.

HY-116572

TASIN-1 hydrochloride	Reactive Oxygen Species (ROS) JNK Apoptosis Caspase	Cancer
TASIN-1 hydrochloride is a selective inhibitor of truncated APC ^TR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 hydrochloride specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 hydrochloride exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 hydrochloride can be used to prevent and intervene in APC mutant colorectal cancer .

HY-116572A

TASIN-1	Reactive Oxygen Species (ROS) JNK Apoptosis Caspase	Cancer
TASIN-1 is a selective inhibitor of truncated APC ^TR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 can be used to prevent and intervene in APC mutant colorectal cancer .

HY-116473

CFM-1	APC	Cancer
CFM-1 is a small molecule antagonist of CARP-1/APC-2 binding with an EC₅₀ value of 4.1 μM. CFM-1 induces G₂M cell cycle arrest and suppresses viabilities of human breast cancer cells .

HY-D2397

Cross-Linked Allophycocyanin CL-APC	Fluorescent Dye	Others
Cross-Linked Allophycocyanin is a trimer biliprotein with maximum absorption at 650 nm .

HY-P0021A

D-Lys(Z)-Pro-Arg-pNA diacetate 1 Publications Verification Spectrozyme PCa; Chromozym Pca diacetate	Fluorescent Dye	Others
D-Lys(Z)-Pro-Arg-pNA diacetate is a chromogenic peptide substrate of activated protein C (APC) .

HY-164467

CCT070535	Wnt	Cancer
CCT070535 blocks TCF-dependent transcription at the TCF level, with GI₅₀ values of 17.6 μM, 11.1 μM, 11.8 μM and 13.4 μM in HT29 (APC mutant), HCT116 (oncogenic β-catenin), SW480 (APC mutant) and SNU475 (Axin mutant) cells, respectively .

HY-P0021

D-Lys(Z)-Pro-Arg-pNA Chromozym Pca	Fluorescent Dye	Others
D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a chromogenic peptide substrate of activated protein C (APC) .

HY-124955

proTAME 5+ Cited Publications	APC	Cancer
proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase .

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	Ser/Thr Protease	Cardiovascular Disease
Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-P1918A

Activated Protein C (390-404), human TFA	APC	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-112968

Human protein C	APC	Cardiovascular Disease
Human Protein C is activated by α-thrombin or α-thrombin/thrombomodulin complex to a serine protease, namely activated protein C (APC). Human Protein C can selectively inactivate factors Va and VIIIa and is a potent anticoagulant .

HY-112968A

Bovine Protein C	APC	Cardiovascular Disease
Bovine Protein C is activated by α-thrombin or α-thrombin/thrombomodulin complex to a serine protease, namely activated protein C (APC). Bovine Protein C can selectively inactivate factors Va and VIIIa and is a potent anticoagulant .

Cat. No.	Product Name	Type

HY-D1815

Allophycocyanin 1 Publications Verification APC Dye	Dyes
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .

HY-P0021A

D-Lys(Z)-Pro-Arg-pNA diacetate 1 Publications Verification Spectrozyme PCa; Chromozym Pca diacetate	Chromogenic Substrates
D-Lys(Z)-Pro-Arg-pNA diacetate is a chromogenic peptide substrate of activated protein C (APC) .

HY-D2180

*Preactivated APC-Cy5.5 Maleimide*	Fluorescent Dyes/Probes
Preactivated APC-Cy5.5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.

HY-D2182

Preactivated PE-Cy5 Maleimide	Fluorescent Dyes/Probes
Preactivated PE-Cy5 Maleimide is a sulfhydryl reactive dye that reacts with free sulfhydryl groups on proteins. Preactivated APC-Cy5.5 Maleimide binds easily to proteins or antibodies, and does not change the spectral characteristics of APC-Cy/YF after activation.

HY-D2397

Cross-Linked Allophycocyanin CL-APC	Dyes
Cross-Linked Allophycocyanin is a trimer biliprotein with maximum absorption at 650 nm .

HY-P0021

D-Lys(Z)-Pro-Arg-pNA Chromozym Pca	Chromogenic Substrates
D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a chromogenic peptide substrate of activated protein C (APC) .

Cat. No.	Product Name	Type

HY-NP053

Ovalbumin-APC OVA-APC	Native Proteins
Ovalbumin-APC (OVA-APC) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-112758

DLin-KC2-DMA 5+ Cited Publications	Drug Delivery
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

HY-NP039

Bovine Serum Albumin-APC BSA-APC	Native Proteins
Bovine Sermu Albumin-APC (BSA-APC) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

Cat. No.	Product Name	Target	Research Area

HY-P2269A

MAIT-203 acetate	Drug Derivative	Cancer
MAIT-203 acetate is a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 acetate binds APC-ARM with a K_i value of 0.015 μM and aK_d value of 0.036 μM. MAIT-203 acetate significantly represses the migration and invasion of colorectal cancer cells .

HY-P0021A

D-Lys(Z)-Pro-Arg-pNA diacetate 1 Publications Verification Spectrozyme PCa; Chromozym Pca diacetate	Fluorescent Dye	Others
D-Lys(Z)-Pro-Arg-pNA diacetate is a chromogenic peptide substrate of activated protein C (APC) .

HY-P1918

Activated Protein C (390-404), human 4 Publications Verification	Ser/Thr Protease	Cardiovascular Disease
Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

HY-P2269

MAIT-203	Drug Derivative	Cancer
MAIT-203, a cyclopentyalanin-derived peptidomimetic, potently inhibits the interaction of adenomatous polyposis coli (APC) and Asef (RhoGEF4), but not APC-Sam68 or APC-striatin interactions. MAIT-203 binds APC-ARM with a K_i of 0.015 μM and a K_d of 0.036 μM. MAIT-203 significantly represses the migration and invasion of colorectal cancer cells.

HY-P0021

D-Lys(Z)-Pro-Arg-pNA Chromozym Pca	Fluorescent Dye	Others
D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a chromogenic peptide substrate of activated protein C (APC) .

HY-P1918A

Activated Protein C (390-404), human TFA	APC	Cardiovascular Disease
Activated Protein C (390-404), human TFA, a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity .

Cat. No.	Product Name	Target	Research Area

HY-P99603

Cifurtilimab SEA-CD40	Inhibitory Antibodies	Cancer
Cifurtilimab (SEA-CD40) is an agonistic nonfucosylated, human IgG1 monoclonal antibody directed against CD40. Cifurtilimab shows antitumor activities .

Species:	Human (7) Virus (2) Mouse (1) Cynomolgus (2) Pig (1)
Tag:	His (10) Tag Free (1) Avi (3) Fc (2)
Source:	HEK293 (10) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74236

	Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) Vitamin K-dependent protein C; APC; Protein C; PROC	Mouse	HEK293
	Factor XIV/PROC protein (or protein C) is an important vitamin K-dependent serine protease that regulates blood clotting.Protein C plays a crucial role in inactivating factors Va and VIIIa and regulating the coagulation cascade in the presence of calcium ions and phospholipids.Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) is the recombinant mouse-derived Coagulation Factor XIV/PROC protein, expressed by HEK293 , with C-His labeled tag.

HY-P74237

	Coagulation Factor XIV/PROC Protein, Human (HEK293, His) Vitamin K-dependent protein C; APC; Protein C; PROC	Human	HEK293
	Coagulation Factor XIV/PROC is a vital vitamin K-dependent serine protease regulating blood coagulation. Active Protein C inactivates factors Va and VIIIa in the presence of calcium ions and phospholipids, maintaining the intricate balance of coagulation pathways. Its protective effect on endothelial cell barrier function underscores a broader impact on vascular integrity. Coagulation Factor XIV/PROC Protein, Human (HEK293, His) is the recombinant human-derived Coagulation Factor XIV/PROC protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor XIV/PROC Protein, Human (HEK293, His) is 443 a.a., with molecular weight of 56-64 & 45 kDa, respectively.

HY-P70936

	EPCR Protein, Human (HEK293, His) Endothelial Protein C Receptor; Activated Protein C Receptor; APC Receptor; Endothelial Cell Protein C Receptor; CD201; PROCR; EPCR	Human	HEK293
	EPCR Protein binds activated protein C, enhancing its activation by the thrombin-thrombomodulin complex, and is pivotal in the protein C pathway, regulating blood coagulation. EPCR Protein, Human (HEK293, His) is the recombinant human-derived EPCR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76907

	EPCR Protein, Cynomolgus (HEK293, His) Endothelial Protein C Receptor; Activated Protein C Receptor; APC Receptor; Endothelial Cell Protein C Receptor; CD201; PROCR; EPCR	Cynomolgus	HEK293
	EPCR Protein plays a pivotal role in blood coagulation by binding to and enhancing the activation of protein C through interaction with the thrombin-thrombomodulin complex. Its significance lies in regulating coagulation processes and modulating protein C activation, a crucial factor in anticoagulant mechanisms. EPCR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived EPCR protein, expressed by HEK293 , with C-His labeled tag.

HY-P700252AF

	Animal-Free TNF-alpha/TNFSF2 Protein, Pig (His) APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Pig	E. coli
	TNF-α/TNFSF2 protein is a cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and has multiple biological functions. It has the ability to induce cell death in specific tumor cell lines, serves as a potent pyrogen, can cause fever through direct action or stimulation of interleukin-1 secretion, and is involved in the induction of cachexia. Animal-Free TNF-alpha/TNFSF2 Protein, Pig (His) is the recombinant pig-derived animal-FreeTNF-alpha/TNFSF2 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P701853

	APC Protein, Human (His) APC; Adenomatous polyposis coli protein; Protein APC; Deleted in polyposis 2.5	Human	E. coli
	The APC protein is a multifaceted tumor suppressor that rapidly degrades CTNNB1 and acts as a negative regulator in the Wnt pathway. Its phosphorylation status intricately affects activity. APC Protein, Human (His) is the recombinant human-derived APC protein, expressed by E. coli , with N-6*His labeled tag.

HY-P76906

	EPCR Protein, Cynomolgus (HEK293, Fc) Endothelial Protein C Receptor; Activated Protein C Receptor; APC Receptor; Endothelial Cell Protein C Receptor; CD201; PROCR; EPCR	Cynomolgus	HEK293
	EPCR Protein plays a pivotal role in blood coagulation by binding to and enhancing the activation of protein C through interaction with the thrombin-thrombomodulin complex. Its significance lies in regulating coagulation processes and modulating protein C activation, a crucial factor in anticoagulant mechanisms. EPCR Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived EPCR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705104

	TNF-alpha/TNFSF2 Protein, Human (Biotinylated, HEK293) APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Human	HEK293

HY-P74042

	*HA/Hemagglutinin Protein, H1N1 (APC57869, sf9, His)* HA; Hemagglutinin; HA/Hemagglutinin Protein, H1N1 (A/USSR/90/1977, sf9, His)	Virus	Sf9 insect cells
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis.HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions.HA/Hemagglutinin Protein, H1N1 (APC57869, sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P74043

	*HA/Hemagglutinin Protein, H1N1 (APC57869, HEK293, His)* HA; Hemagglutinin; HA/Hemagglutinin Protein, H1N1 (A/USSR/90/1977, HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis.HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions.HA/Hemagglutinin Protein, H1N1 (APC57869, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P78527

	TNF-alpha/TNFSF2 Protein, Human (HEK293, His-Avi) APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Human	HEK293
	Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine. TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis. Anti-TNF-α MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse. TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury. TNF-alpha/TNFSF2 Protein, Human (HEK293, His-Avi) is a recombinant protein with a C-Terminal Avi and a His label, It consists of 157 amino acids (V77-L233) and is produced in HEK293 cells.

HY-P78218

	TNF-alpha/TNFSF2 Protein, Human (Biotinylated, HEK293, His-Avi) 2 Publications Verification APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Human	HEK293
	Tumour Necrosis Factor alpha (TNF alpha) is a potent pro-inflammatory cytokine. TNF alpha binds to its receptors, mainly TNFR1 and TNFR2, and then transmits molecular signals for biological functions such as inflammation and cell death. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis. Anti-TNF-α MAb significantly suppresses the tumor development in colitis-associated cancer (CAC) mouse. TNF alpha as a proneurogenic factor activates the SAPK/JNK Pathway and can facilitate neuronal replacement and brain repair in response to brain injury. TNF-alpha/TNFSF2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein with a C-Terminal Avi and a His label, It consists of 157 amino acids (V77-L233) and is produced in HEK293 cells.

HY-P705103

	TNF-alpha/TNFSF2 Protein, Human (Biotinylated, HEK293, Fc-Avi) APC1 protein; Cachectin; DIF; TNF; TNFalpha; TNFATNF; TNFSF1A; TNFSF2; TNFA; TNFα; DIF; TNFSF2	Human	HEK293

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80016

	APC Antibody (YA617)	WB, ICC/IF, IP	Human, Mouse
	APC Antibody (YA617) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APC.

HY-P80017

	APC6 Antibody (YA616)	WB, ICC/IF	Human, Rat
	APC6 Antibody (YA616) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APC6.

HY-P83714M

	*Rat Anti-Mouse CD206 Antibody (APC)* 1 Publications Verification MMR; MR; MRC1; macrophage mannose receptor; mannose receptor	FC	Mouse
	Rat Anti-Mouse CD206 Antibody (APC) is a rat-derived and allophycocyanin (APC) IgG2a monoclonal antibody, targeting to CD206.

HY-P83881

	APC2 Antibody (YA3578) APCL	IHC-P, ICC/IF, FC, ELISA	Human
	APC2 Antibody (YA3578) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to APC2.

HY-P87420

	Apc11/ANAPC11 Antibody (YA7108)	FC, ELISA	Human

HY-P84877

	ANAPC10 Antibody (YA4574) DOC1; APC10	WB, IHC-P, ICC/IF, FC, ELISA	Human
	ANAPC10 Antibody (YA4574) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ANAPC10.

HY-P84789

	ANAPC1 Antibody (YA4486) APC1; MCPR; TSG24	ICC/IF, FC, ELISA	Human
	ANAPC1 Antibody (YA4486) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ANAPC1.

HY-P83713M

	*CD11c Antibody (APC)(YA3450)* Integrinalpha-X; Itgax; CD11antigen-likefamilymemberC; Leukocyteadhesionreceptorp150+95; CD11c	FC	Mouse
	CD11c Antibody (APC)(YA3450) is an Armenian hamster-derived and allophycocyanin (APC) IgG monoclonal antibody, targeting to CD11c.

HY-P82297

	ApoH Antibody (YA2042) APC inhibitor; APOH; Apolipoprotein H; B2G1; B2GP1; B2GPI; BG	WB, ICC/IF, IP	Human, Rat
	ApoH Antibody (YA2042) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ApoH.

HY-P83666M

	*Human CD235 Antibody (APC) (YA3400)* Glycophorin-A/B; GYPA/B; MN sialoglycoprotein; SS-active sialoglycoprotein; PAS-2/3; Sialoglycoprotein alpha/delta; CD235a/b	FC	Human
	Human CD235 Antibody (APC) (YA3400) is an APC-conjugated, mouse-derived, anti-Human CD235 IgG1 monoclonal antibody.

HY-P85097

	Cdc27 Antibody (YA4789) CDC27; ANAPC3; D0S1430E; D17S978E; Cell division cycle protein 27 homolog; Anaphase-promoting complex subunit 3; APC3; CDC27 homolog; CDC27Hs; H-NUC	WB, IHC-P, ICC/IF, ELISA	Human
	Cdc27 Antibody (YA4789) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cdc27.

HY-P86862

	EPCR Antibody (YA6555) Activated protein C receptor antibody; APC receptor antibody; APCR antibody; bA42O4.2 antibody; CCCA antibody; CCD41 antibody; CD201 antibody; CD201 antigen antibody; cell cycle, centrosome-associated protein antibody; Cell cycle, centrosome-associated protein antibody; Activated protein C receptor antibody; APC receptor antibody; APCR antibody; bA42O4.2 antibody; CCCA antibody; CCD41 antibody; CD201 antibody; CD201 antigen antibody; cell cycle, centrosome-associated protein antibody; Cell cycle, centrosome-associated protein antibody; centrocyclin antibody; Endothelial cell protein C receptor antibody; Endothelial protein C receptor antibody; EPCR antibody; EPCR_HUMAN antibody; MGC23024 antibody; PROCR antibody; Protein C receptor, endothelial antibody;	WB, ICC/IF, FC	Human
	EPCR Antibody (YA6555) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to EPCR.

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Cat. No.	Product Name		Classification

HY-130530

AP-C5		Alkynes
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS00808

Apc Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Apc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00809

Apc Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Apc Rat Pre-designed siRNA Set A contains three designed siRNAs for Apc gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00807

APC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APC Human Pre-designed siRNA Set A contains three designed siRNAs for APC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00810

APC2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APC2 Human Pre-designed siRNA Set A contains three designed siRNAs for APC2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16390

APCS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APCS Human Pre-designed siRNA Set A contains three designed siRNAs for APCS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20692

Apcs Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Apcs Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apcs gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27203

Apcs Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Apcs Rat Pre-designed siRNA Set A contains three designed siRNAs for Apcs gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11190

PROC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PROC Human Pre-designed siRNA Set A contains three designed siRNAs for PROC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-159746

HS801		Adjuvant
HS801 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .

HY-159754

HS201		Adjuvant
HS201 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .

HY-159753

HS105		Adjuvant
HS105 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .

HY-159752

HS103		Adjuvant
HS103 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .

HY-159743

M101		Adjuvant
M101 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .

HY-159751

HS101		Adjuvant
HS101 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .

HY-159744

M103		Adjuvant
M103 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .

HY-159745

M107		Adjuvant
M107 is a vaccine adjuvant and a key component in vaccines. Adjuvants can be divided into immunostimulants and delivery systems. Adjuvants can not only enhance the intensity and durability of immune responses, but also affect the type of immune responses. On the one hand, immunostimulants promote the production of antigen signals and co-stimulatory signals by targeting Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs), leading to the maturation and activation of antigen presenting cells (APCs), thereby enhancing adaptive immune responses; on the other hand, delivery systems are carrier materials that promote antigen delivery by prolonging the bioavailability of loaded antigens and targeting antigens to lymph nodes or APCs. Several common adjuvants include: saponins, TLRs agonists, polysaccharides, nanoparticles, cytokines, and mucosal adjuvants .

HY-112758

DLin-KC2-DMA 5+ Cited Publications		Cationic Lipids
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

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