APOE

Isoforms Recommended:	apoE

By Targets:	Akt (1) Apolipoprotein (4) Bacterial (1) c-Myc (1) Endogenous Metabolite (1) Fatty Acid Synthase (FASN) (1) GCGR (1) Heme Oxygenase (HO) (1) JNK (1) LXR (2) MEK (1) MMP (1) nAChR (2) NO Synthase (2) PPAR (1) RAR/RXR (1) Sirtuin (2) Small Interfering RNA (siRNA) (2) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (6) Infection (1) Inflammation/Immunology (5) Metabolic Disease (4) Neurological Disease (6)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1050

COG 133 2 Publications Verification	nAChR	Neurological Disease Inflammation/Immunology
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC₅₀ of 445 nM .

HY-P1050A

COG 133 TFA 2 Publications Verification	Apolipoprotein nAChR	Neurological Disease Inflammation/Immunology
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC₅₀ of 445 nM .

HY-103076

EZ-482 1 Publications Verification	Apolipoprotein	Neurological Disease
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with K_ds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas .

HY-111498

RGX-104 hydrochloride 2 Publications Verification Abequolixron hydrochloride	LXR	Inflammation/Immunology Cancer
RGX-104 hydrochloride is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-111498A

RGX-104 2 Publications Verification Abequolixron	LXR	Inflammation/Immunology Cancer
RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-RS00850

Apoe Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apoe Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoe gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apoe Mouse Pre-designed siRNA Set A Apoe Mouse Pre-designed siRNA Set A

HY-RS00849

APOE Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APOE Human Pre-designed siRNA Set A contains three designed siRNAs for APOE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APOE Human Pre-designed siRNA Set A APOE Human Pre-designed siRNA Set A

HY-169080

ABCA1 inducer 1	Apolipoprotein	Neurological Disease
ABCA1 inducer 1 is a nonlipogenic ABCA1 inducer. ABCA1 inducer 1 increases ABCA1 expression, enhances apolipoprotein (APOE) lipidation and reverses multiple Alzheimer’s disease (AD) phenotypes, without increasing triglycerides in E3/4FAD mice that express human APOE 3/4 .

HY-121417

Laserpitin	Apolipoprotein	Cardiovascular Disease Metabolic Disease
Laserpitin, a coumarin, increases serum HDL levels, especially apoE-HDL, and decreases the hepatic triglyceride content in stroke-prone spontaneously hypertensive rats (SHRSP) .

HY-113086

CE(16:1(9Z)) 16:1(9Z) CE; 16:1(9Z) Cholesterol ester; Cholesterol Palmitoleate	Endogenous Metabolite	Cardiovascular Disease
Cholesteryl palmitoleate is a cholesterol ester. Plasma levels of cholesteryl palmitoleate are increased in ApoE-/- mice exposed to cigarette smoke and in pediatric patients with biliary atresia. Cholesteryl palmitoleate has been used as a standard for the identification of cholesterol esters in human meibomian gland secretions.

HY-121671

TBTC	RAR/RXR	Neurological Disease
TBTC is a selective agonist with the activity of improving behavioral deficits in Alzheimer's disease model mice. TBTC can effectively activate the heterodimerization of RXRα with LXRα or PPARγ. TBTC stimulates the expression of apoE, ABCA1, and ABCG1 genes and reduces Aβ content in cells and animal models .

HY-P0119

Lixisenatide 2 Publications Verification	GCGR MEK Akt MMP JNK	Neurological Disease Metabolic Disease Inflammation/Immunology
Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ^−/− Irs ^2+/− mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .

HY-W424839

Probucol dithiobisphenol DTBP	Heme Oxygenase (HO)	Cardiovascular Disease
Probucol dithiobisphenol (DTBP) is the derivative of Probucol (HY-B0388). Probucol dithiobisphenol induces the production of heme oxygenase 1 (HO-1), and exhibits antioxidant activity. Probucol dithiobisphenol inhibits atherosclerotic lesions in Apoe ^−/− mice aorta, promotes re-endothelialization of aorta and inhibits restenosis in rabbit arterial injury models. Probucol dithiobisphenol is orally active .

HY-P10586A

Macrophage-activating lipopeptide 2 TFA MALP-2 TFA	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease Metabolic Disease
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-117006

E1231 1 Publications Verification 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one	Sirtuin	Cardiovascular Disease
E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC₅₀=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (K_D=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE ^-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases .

HY-P10586

Macrophage-activating lipopeptide 2 MALP-2	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease
Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-N0704

Agrimol B 1 Publications Verification	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Infection Metabolic Disease Cancer
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and *apoE* expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

Cat. No.	Product Name	Target	Research Area

HY-P1050A

COG 133 TFA 2 Publications Verification	Apolipoprotein nAChR	Neurological Disease Inflammation/Immunology
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC₅₀ of 445 nM .

HY-P0119

Lixisenatide 2 Publications Verification	GCGR MEK Akt MMP JNK	Neurological Disease Metabolic Disease Inflammation/Immunology
Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ^−/− Irs ^2+/− mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .

HY-P10586A

Macrophage-activating lipopeptide 2 TFA MALP-2 TFA	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease Metabolic Disease
Macrophage-activating lipopeptide 2 TFA is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 enhances endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 enhances endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

HY-P10586

Macrophage-activating lipopeptide 2 MALP-2	Toll-like Receptor (TLR) NO Synthase	Cardiovascular Disease
Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0704

Agrimol B 1 Publications Verification	Agrimonia pilosa Ledeb. Structural Classification Classification of Application Fields Rosaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and *apoE* expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, SKP2 and p27 .

Species:	Human (7) Mouse (2) Rat (1) Rabbit (2)
Tag:	His (8) SUMO (1) Myc (1) B2M (1) Fc (4)
Source:	HEK293 (9) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P7531

	*Apolipoprotein E/APOE3 Protein, Human (HEK293, His)* rHuApolipoprotein E, His; APOE; Apolipoprotein E; APOE3	Human	HEK293
	Apolipoprotein E/ApoE3 is an apolipoprotein isoform that mediates lipid transport and plays a crucial role in lipid homeostasis in both plasma and the central nervous system by binding to LDL receptors (LDLR), LDL receptor-related proteins (LRP1, LRP2, LRP8), Very Low-Density Lipoprotein Receptor (VLDLR), and Heparin. The Apolipoprotein E/ApoE3 Protein, Human (HEK293, His) is a recombinant protein with a His tag at the N-terminus, consisting of 299 amino acids (K19-H317), and is expressed in HEK293 cells.

HY-P7532

	*Apolipoprotein E/APOE* Protein, Mouse (HEK293, His)** rMuApolipoprotein E, His; APOE; Apolipoprotein E	Mouse	HEK293
	Apolipoprotein E Protein, Mouse (HEK293, His) expresses in HEK293 with a His tag at the N-terminus. Apolipoprotein E regulates tight junction (TJs) function by regulating PKCη activity and phosphorylation of occludin on its Thr residues in an isoform-dependent manner. Apolipoprotein E also promotes cholesterol release.

HY-P72084

	*Apolipoprotein E/APOE* Protein, Rabbit (His-B2M, Myc)** APOEApolipoprotein E; Apo-E	Rabbit	E. coli
	Apolipoprotein E/APOE is essential for lipid transport between organs and is a key component of lipoproteins such as chylomicrons and high-density lipoprotein. It binds to cell receptors such as LDLR and VLDLR to promote lipoprotein uptake, and has heparin-binding activity to interact with cell surface proteoglycans. Apolipoprotein E/APOE Protein, Rabbit (His-B2M, Myc) is the recombinant Rabbit-derived Apolipoprotein E/APOE protein, expressed by E. coli , with N-10*His, C-Myc, N-B2M labeled tag. The total length of Apolipoprotein E/APOE Protein, Rabbit (His-B2M, Myc) is 292 a.a., with molecular weight of ~55 kDa.

HY-P700853

	*Apolipoprotein E/APOE4 Protein, Human (HEK293, His)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE4	Human	HEK293

HY-P701051

	*Apolipoprotein E/APOE3 Protein, Human (HEK293, hFc)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE3 Protein, Human (HEK293, hFc) is the recombinant human-derived Apolipoprotein E/APOE3 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Apolipoprotein E/APOE3 Protein, Human (HEK293, hFc) is 299 a.a., with molecular weight of 60-70 kDa.

HY-P78062

	*Apolipoprotein E/APOE3 Protein, Human (Biotinylated, HEK293, His)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE3	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with N-His labeled tag. The total length of Apolipoprotein E/APOE Protein, Human (Biotinylated, HEK293, His) is 299 a.a., with molecular weight of 35-40 kDa.

HY-P78542A

	*Apolipoprotein E/APOE4 Protein, Human (C130R, HEK293, Fc)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE4	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (C130R, HEK293, Fc) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with N-hFc labeled tag and C130R, , , , mutation. The total length of Apolipoprotein E/APOE4 Protein, Human (C130R, HEK293, Fc) is 299 a.a., with molecular weight (glycosylation form) of 63-68 kDa.

HY-P78239

	*Apolipoprotein E/APOE* Protein, Mouse (HEK293, Fc)** Apolipoprotein E; Apo-E; APOE; apolipo E	Mouse	HEK293
	Apolipoprotein E/APOE is crucial in lipid transport and participates in the production, transformation and clearance of plasma lipoproteins. It interacts with various particles, including chylomicrons and high-density lipoproteins, and binds to cellular receptors such as LDLR and VLDLR, promoting uptake. Apolipoprotein E/APOE Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Apolipoprotein E/APOE Protein, Mouse (HEK293, Fc) is 293 a.a., with molecular weight of 62-66 kDa.

HY-P78542

	*Apolipoprotein E/APOE4 Protein, Human (C130R, HEK293, Fc, solution)* Apolipoprotein E; Apo-E; APOE; apolipo E; APOE4	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (C130R, HEK293, Fc) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with N-hFc labeled tag and C130R, , , , mutation. The total length of Apolipoprotein E/APOE Protein, Human (C130R, HEK293, Fc) is 299 a.a., with molecular weight (glycosylation form) of 63-67 kDa.

HY-P72083

	*Apolipoprotein E/APOE* Protein, Rabbit (His-SUMO)** APOEApolipoprotein E; Apo-E	Rabbit	E. coli
	Apolipoprotein E/APOE is essential for lipid transport between organs and is a key component of lipoproteins such as chylomicrons and high-density lipoprotein. It binds to cell receptors such as LDLR and VLDLR to promote lipoprotein uptake, and has heparin-binding activity to interact with cell surface proteoglycans. Apolipoprotein E/APOE Protein, Rabbit (His-SUMO) is the recombinant Rabbit-derived Apolipoprotein E/APOE protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag. The total length of Apolipoprotein E/APOE Protein, Rabbit (His-SUMO) is 292 a.a., with molecular weight of ~53.6 kDa.

HY-P701094

	*Apolipoprotein E/APOE2 Protein, Human (R154S, R176C, HEK293, C-His)* Apolipoprotein E; APOE; Apo-E; APOE2	Human	HEK293
	Apolipoprotein E (APOE) plays a key role in lipoprotein-mediated lipid transport and is a core component in the production, transformation, and clearance of plasma lipoproteins. As an amphipathic molecule, APOE binds to various lipoprotein particles, including chylomicrons, chylomicron remnants, VLDL, and IDL, favoring HDL. Apolipoprotein E/APOE Protein, Human (R154S, R176C, HEK293, C-His) is the recombinant human-derived Apolipoprotein E/APOE protein, expressed by HEK293 , with C-6*His labeled tag and R154S, R176C, , , mutation. The total length of Apolipoprotein E/APOE Protein, Human (R154S, R176C, HEK293, C-His) is 299 a.a., with molecular weight of 33-42 kDa.

HY-P701096

	*Apolipoprotein E/APOE* Protein, Rat (His)** APOEApolipoprotein E; Apo-E	Rat	E. coli
	Apolipoprotein E/APOE is essential for lipid transport and is integral to the production, transformation and clearance of plasma lipoproteins.It interacts with various particles to favor HDL and binds to receptors such as LDLR and VLDLR to promote cellular uptake.Apolipoprotein E/APOE Protein, Rat (His) is the recombinant rat-derived Apolipoprotein E/APOE protein, expressed by E.coli , with N-6*His labeled tag.

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HY-P81771

	ApoE Antibody (YA1516) APOE; Apolipoprotein E; Apo-E	WB, IHC-P, ICC/IF, IP	Human, Mouse
	ApoE Antibody (YA1516) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1516), targeting ApoE, with a predicted molecular weight of 36 kDa. ApoE Antibody (YA1516) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse background.

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HY-RS00850

Apoe Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Apoe Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoe gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00849

APOE Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APOE Human Pre-designed siRNA Set A contains three designed siRNAs for APOE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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