ES | MedChemExpress (MCE) Life Science Reagents

By Targets:	Androgen Receptor (1) Antibiotic (1) Apoptosis (2) Autophagy (4) Biochemical Assay Reagents (1) EGFR (1) Estrogen Receptor/ERR (2) GSK-3 (5) Interleukin Related (1) Isotope-Labeled Compounds (1) Liposome (1) Organoid (2) PD-1/PD-L1 (2) PKC (2) RAR/RXR (1) Renin (2) Steroid Sulfatase (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) Wnt (4) β-catenin (4)
By Research Areas:	Cancer (17) Cardiovascular Disease (2) Endocrinology (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131683

ES9-17 1 Publications Verification	Others	Others
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings .

HY-100367

ES 936	Others	Cancer
ES 936 is a potent and specific NQO1 inhibitor, effective at concentrations over 1000 times lower than the non-specific inhibitor Dicoumarol (HY-N0645). NQO1 is generally considered a detoxification enzyme, capable of directly reducing quinones to hydroquinones, which in turn prevents the formation of reactive oxygen species arising from redox cycling. ES 936 can be utilized in cancer research .

HY-U00112

Estradiol 3-sulfamate BLE 00084; E2MATE; ES-J 995	Steroid Sulfatase	Cancer
Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC₅₀ of 251 nM and a K_i of 133 nM.

HY-120821

Endosidin-2 ES2	Others	Others
Endosidin2 (ES2) binds to the exocyst component of 70 kDa (EXO70) subunit of the exocyst complex with a K_d of 253 μM. Endosidin2 inhibits exocytosis and endosomal recycling in both plant and human cells and enhances plant vacuolar trafficking. Endosidin2 is a valuable new tool for the study of exocytosis .

HY-125625

ES 6864	Renin	Cardiovascular Disease
ES 6864 is an orally active, competitive inhibitor for human renin, with an IC₅₀ of 6.9 nM and a K_i of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets .

HY-117913

ES-8891	Renin	Cardiovascular Disease
ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis .

HY-164476

ES-072	EGFR GSK-3 PD-1/PD-L1	Cancer
ES-072 is an orally effective selective EGFR mutant (EGFR-T790M) inhibitor. ES-072 activates GSK3α by inhibiting EGFR-T790M activity, which promotes phosphorylation of PD-L1 at Ser279 and Ser283. The phosphorylated PD-L1 recruits the E3 ubiquitin ligase ARIH1, leading to ubiquitination and proteasomal degradation of PD-L1. This mechanism not only reduces cancer cell growth but also enhances anti-tumor immune response by lowering PD-L1 levels. ES-072 can be used to inhibit proliferation in non-small cell lung cancer (NSCLC) cells .

HY-13626

Spisulosine ES-285	PKC	Cancer
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation .

HY-159621

Endosidine 5 ES5	Others	Endocrinology
Endosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm .

HY-P990738

Enristomig ES-101; INBRX-105	TNF Receptor PD-1/PD-L1	Inflammation/Immunology
Enristomig is an anti-TNFRSF9/CD274 monoclonal antibody .

HY-158709

Cho-es-Lys	Biochemical Assay Reagents Liposome	Others
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

HY-112483

QX77 3 Publications Verification	Autophagy	Cancer
QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells . QX77 can impede self-renewal and promote differentiation of ES cells .

HY-150047

BK60106	Apoptosis	Cancer
BK60106 is a CD99 inhibitor that directly binds to the extracellular domain of CD99. BK60106 selectively kill Ewing sarcoma (ES) cells. BK60106 induces apoptosis in ES cells with less DNA damage .

HY-13626S

Spisulosine-d3	Isotope-Labeled Compounds PKC	Cancer
Spisulosine-d₃ is deuterium labeled Spisulosine. Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKC

HY-161239A

IB-96212	Antibiotic	Infection Cancer
IB-96212 (compound 5) is a member of oligomycin class which can be extracted ftom the marine Micromonospora sp. L-25-ES25-008 ref. IB-96212 is an antitumor antibiotic against P-388, it also exhibits antimicrobial activity against Micrococcus luteus .

HY-N2335

Coumestrol 3 Publications Verification	Estrogen Receptor/ERR	Cancer
Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC₅₀ of 50 μM.

HY-164373

SC428	Androgen Receptor Apoptosis	Cancer
SC428 is an androgen receptor (AR) inhibitor that targets the N-terminal domain. SC428 potently decrease the transactivation of (AR)-V7, (AR)v567es, as well as full-length ( AR ) (AR-FL) and its LBD mutants, substantially. SC428 inhibits androgen-stimulated (AR)-FL nuclear translocation, chromatin binding, and (AR) -regulated gene transcription. SC428 inhibits the proliferation of tumor cells in vitro. SC428 inhibits tumor cell growth by inducing apoptosis in mice transplanted with 22RV1 .

HY-N2335R

Coumestrol (Standard)	Estrogen Receptor/ERR	Cancer
Coumestrol (Standard) is the analytical standard of Coumestrol. This product is intended for research and analytical applications. Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

HY-137007

SMA-12b	Interleukin Related	Others Inflammation/Immunology
SMA-12b is a small molecule analogue of the parasitic worm compound ES-62. SMA-12b has immunomodulatory activity, acting by regulating the expression of multiple inflammatory response genes, especially those associated with inflammatory bodies. SMA-12b significantly reduces the expression of cytokine IL-1β associated with inflammatory bodies and inhibites the production of IL-1β through a mechanism mediated by NRF2. SMA-12b can be used in the study of rheumatoid arthritis (RA) and other autoimmune diseases .

HY-160715

BNT411	Toll-like Receptor (TLR)	Cancer
BNT411 is a selective TLR7 agonist that can induce the release of IFNa both in vivo and in vitro. BNT411 has anticancer activity and can be used in cancer research, including non-small cell lung cancer, pancreatic cancer, and untreated extensive-stage small cell lung cancer (ES-SCLC) .

HY-10182

Laduviglusib Maximum Cited Publications 166 Publications Verification CHIR-99021; CT99021	Organoid GSK-3 Wnt β-catenin Autophagy	Metabolic Disease Cancer
Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy .

HY-10182C

Laduviglusib dihydrochloride CHIR-99021 dihydrochloride; CT99021 dihydrochloride	GSK-3 β-catenin Wnt	Metabolic Disease Cancer
Laduviglusib;CHIR 99021;CHIR99021;CHIR-99021;CT99021;CT 99021;CT-99021

HY-10182R

Laduviglusib (Standard) CHIR-99021 (Standard); CT99021 (Standard)	Organoid GSK-3 Autophagy Wnt β-catenin	Cancer
Laduviglusib (Standard) is the analytical standard of Laduviglusib. Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy .

HY-10182G

Laduviglusib CHIR-99021; CT99021	GSK-3 Wnt β-catenin Autophagy	Metabolic Disease Cancer
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-14649G

Retinoic acid Vitamin A acid; all-trans-Retinoic acid; ATRA	RAR/RXR	Cancer
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors .

Cat. No.	Product Name	Type

HY-10182G

Laduviglusib (GMP) CHIR-99021 (GMP); CT99021 (GMP)	Fluorescent Dye
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-14649G

Retinoic acid (GMP) Vitamin A acid (GMP); all-trans-Retinoic acid (GMP); ATRA (GMP)	Fluorescent Dye
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors .

Cat. No.	Product Name	Type

HY-10182G

Laduviglusib (GMP) CHIR-99021 (GMP); CT99021 (GMP)	Biochemical Assay Reagents
Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

HY-14649G

Retinoic acid (GMP) Vitamin A acid (GMP); all-trans-Retinoic acid (GMP); ATRA (GMP)	Biochemical Assay Reagents
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors .

HY-158709

Cho-es-Lys	Drug Delivery
Cho-es-Lys is a cationic lipid synthesized by coupling natural cholesterol and amino acids, which has high gene transfection efficiency. Cho-es-Lys can be used in drug delivery research .

Cat. No.	Product Name	Target	Research Area

HY-P990738

Enristomig ES-101; INBRX-105	TNF Receptor PD-1/PD-L1	Inflammation/Immunology
Enristomig is an anti-TNFRSF9/CD274 monoclonal antibody .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2335

Coumestrol 3 Publications Verification	Structural Classification Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Estrogen Receptor/ERR
Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC₅₀ of 50 μM.

HY-13626

Spisulosine ES-285	Alkaloids Classification of Application Fields Animals Source classification Marine natural products Other marine organisms Disease Research Fields Cancer	PKC
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation .

HY-N2335R

Coumestrol (Standard)	Structural Classification Leguminosae Glycine max (L.) merr Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants	Estrogen Receptor/ERR
Coumestrol (Standard) is the analytical standard of Coumestrol. This product is intended for research and analytical applications. Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

Species:	Human (2) Mouse (3)
Tag:	His (5) GST (2) MBP (1) Flag (1)
Source:	HEK293 (1) P. pastoris (1) Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P71802

	Carboxylesterase 1C Protein, Mouse (P.pastoris, His) CarboxylESterase 1C; CES N; CES1c; Ee 1; Ee 4; Ee1; ES N; ES1; ES4; ESN; EST1C_MOUSE; ESterase 1; Liver carboxylESterase N; Lung surfactant convertase; PES-N; PESN	Mouse	P. pastoris
	The carboxylesterase 1C protein is essential for xenobiotic detoxification and ester/amide prodrug activation, as well as participating in extracellular metabolism. Its multifunctional effects include processing of pulmonary surfactant. Carboxylesterase 1C Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Carboxylesterase 1C protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Carboxylesterase 1C Protein, Mouse (P.pastoris, His) is 532 a.a., with molecular weight of ~60.6 kDa.

HY-P72963

	Cyclin E Protein, Human (sf9, His-GST) CCNE; CCNE1; CCNEcyclin ES; Cyclin E1; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	Cyclin E controls the G1/S transition of the cell cycle. Cyclin E Protein, Human (SF9, His-GST) is the recombinant human-derived Cyclin E protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Cyclin E Protein, Human (SF9, His-GST) is 410 a.a., with molecular weight of ~70 kDa.

HY-P72964

	Cyclin E Protein, Mouse (sf9, His-GST) CCNE; CCNE1; CCNEcyclin ES; Cyclin E1; G1/S-specific cyclin-E1	Mouse	Sf9 insect cells
	Cyclin E, a vital regulator in cell cycle control, governs the G1/S transition by forming a potent serine/threonine kinase complex with CDK2. This complex, featuring UHRF2, CDK2, and CCNE1, involves Cyclin E's direct interaction with UHRF2, leading to CCNE1 ubiquitination independently of phosphorylation. Cyclin E's intricate dance with CDK2, CABLES1, and CCNA1 highlights its crucial role in tightly regulated cell cycle progression. Cyclin E Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Cyclin E protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702029

	SLC29A1 Protein, Human (Sf9, His, MBP, FLAG) SLC29A1; Equilibrative nucleoside transporter 1; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter; ES-type; Solute carrier family 29 member 1	Human	Sf9 insect cells
	The SLC29A1 protein is an important uniporter that actively promotes the transport of nucleosides and nucleobases and maintains cellular homeostasis of essential compounds. As a Na(+)-independent transporter, SLC29A1 efficiently transports a series of nucleosides and nucleobases, including adenosine, guanosine, inosine, uridine, thymidine, cytidine, hypoxanthine, adenine, guanine, Thymine and uracil. SLC29A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC29A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC29A1 Protein, Human (Sf9, His, MBP, FLAG) is 455 a.a., .

HY-P70088

	CES3/CES1D Protein, Mouse (HEK293, His) rMuCarboxylESterase 1D/CES3, His; CES3; carboxylESterase 3; carboxylESterase 3 (brain); EC 3.1.1; EC 3.1.1.1; ES31FLJ21736; ESterase 31; Liver carboxylESterase 31 homolog	Mouse	HEK293
	CES3/CES1D Protein, a major lipase in white adipose tissue, plays a crucial role in xenobiotic and natural substrate metabolism. It hydrolyzes triacylglycerols and monoacylglycerols, showing a preference for the latter, with susceptibility increasing as the acyl chain length decreases. Additionally, CES3/CES1D catalyzes the synthesis of fatty acid ethyl esters and hydrolyzes retinyl esters. CES3/CES1D Protein, Mouse (HEK293, His) is the recombinant mouse-derived CES3/CES1D protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CES3/CES1D Protein, Mouse (HEK293, His) is 543 a.a., with molecular weight of 58-70 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-13626S

Spisulosine-d3
Spisulosine-d₃ is deuterium labeled Spisulosine. Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKC

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82583

	Liver Carboxylesterase 1 Antibody (YA2328) ACAT; CE 1; CEH; CES1; CES2; CESDD1; Egasyn; ES-HTEL; ES-x; ES22; ESterase 22; hCE 1; HMSE; HMSE1; REH; SES1; TGH; Triacylglycerol hydrolase	WB, IP, FC	Human, Mouse, Rat
	Liver Carboxylesterase 1 Antibody (YA2328) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2328), targeting Liver Carboxylesterase 1, with a predicted molecular weight of 63 kDa (observed band size: 55 kDa). Liver Carboxylesterase 1 Antibody (YA2328) can be used for WB, IP, FC experiment in human, mouse, rat background.

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ES

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

ES

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products