Search Result

Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

Enzyme inhibitory activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (7) IDE (1) Proteolytic Enzyme (1) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) Antifolate (1) Apoptosis (5) Autophagy (2) Bacterial (11) Bcr-Abl (1) c-Kit (1) Casein Kinase (1) CDK (2) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (1) COX (1) Cytochrome P450 (4) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (1) Drug Metabolite (1) EGFR (1) Elastase (1) Endogenous Metabolite (7) FAAH (1) FGFR (1) FLT3 (2) Fungal (1) Glycosidase (2) HDAC (2) Herbicide (1) Histone Methyltransferase (1) HIV (5) HIV Integrase (1) Influenza Virus (3) JAK (1) Ligands for Target Protein for PROTAC (1) Lipoxygenase (1) Na+/K+ ATPase (1) Parasite (3) PGE synthase (1) Phosphatase (1) Phospholipase (1) PI3K (1) Pim (1) Potassium Channel (2) Reactive Oxygen Species (2) Renin (1) Reverse Transcriptase (1) SARS-CoV (3) Ser/Thr Protease (1) Thymidylate Synthase (2) TMV (1) Trk Receptor (2) TrxR (1) VD/VDR (1) VEGFR (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (10) Endocrinology (1) Infection (21) Inflammation/Immunology (9) Metabolic Disease (7) Neurological Disease (2)

By Targets:

Angiotensin-converting Enzyme (ACE) (7)

IDE (1)

Proteolytic Enzyme (1)

Aldehyde Dehydrogenase (ALDH) (1)

Aldose Reductase (1)

Amyloid-β (1)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (1)

Antifolate (1)

Apoptosis (5)

Autophagy (2)

Bacterial (11)

Bcr-Abl (1)

c-Kit (1)

Casein Kinase (1)

CDK (2)

Checkpoint Kinase (Chk) (1)

Cholinesterase (ChE) (1)

COX (1)

Cytochrome P450 (4)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

EGFR (1)

Elastase (1)

Endogenous Metabolite (7)

FAAH (1)

FGFR (1)

FLT3 (2)

Fungal (1)

Glycosidase (2)

HDAC (2)

Herbicide (1)

Histone Methyltransferase (1)

HIV (5)

HIV Integrase (1)

Influenza Virus (3)

JAK (1)

Ligands for Target Protein for PROTAC (1)

Lipoxygenase (1)

Na+/K+ ATPase (1)

Parasite (3)

PGE synthase (1)

Phosphatase (1)

Phospholipase (1)

PI3K (1)

Pim (1)

Potassium Channel (2)

Reactive Oxygen Species (2)

Renin (1)

Reverse Transcriptase (1)

SARS-CoV (3)

Ser/Thr Protease (1)

Thymidylate Synthase (2)

TMV (1)

Trk Receptor (2)

TrxR (1)

VD/VDR (1)

VEGFR (1)

By Research Areas:

Cancer (21)

Cardiovascular Disease (10)

Endocrinology (1)

Infection (21)

Inflammation/Immunology (9)

Metabolic Disease (7)

Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Targets Recommended: Macrophage migration inhibitory factor (MIF) Proteolytic Enzyme Endothelin-Converting Enzyme (ECE) Angiotensin-converting Enzyme (ACE) NEDD8-activating Enzyme E1/E2/E3 Enzyme IDE IRE1 TET Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9528

Lyciumin A	Angiotensin-converting Enzyme (ACE) Renin	Cardiovascular Disease
Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension .

HY-N2472

Medicagenic acid Castanogenin	Bacterial	Infection
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-130666

Chlorambucyl-proline	Endogenous Metabolite	Cardiovascular Disease
Chlorambucyl-proline is a chloroplatinyl amino acid derivative with inhibitory activity against bovine pulmonary vasoconstrictor enzyme. Chlorambucyl-proline reacts with the convertase in a 1:1 ratio, and the removal of its radiolabel indicates that the compound has an irreversible inhibitory effect on the enzyme activity. Chlorambucyl-proline binds to the aspartic acid or glutamic acid side chain of the enzyme by forming an ester bond, resulting in irreversible inactivation of the enzyme. The inactivation rate constant of chlororambucyl-proline increases in the pH range of 5-8, indicating that its effect on the enzyme activity is affected by the pH environment .

HY-101577

NCX899	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
NCX899 is a NO-releasing derivative of enalapril, and shows inhibitory activity against *angiotensin-converting enzyme* (ACE)** activity.

HY-147730

HDAC6-IN-8	HDAC	Cancer
A variety of compounds were designed and synthesized by modifying cap groups. The enzyme inhibition test showed that compound 12C had broad-spectrum enzyme inhibitory activity, and compounds 9m and 9q were more inclined to inhibit HDAC6, showing a certain selective inhibitory activity among the representative subtypes.

HY-P1619

ICI 186756	Elastase	Others
ICI 186756 is a compound that inhibits the activity of human neutrophil elastase, has a competitive inhibitory effect on the enzyme, can inhibit enzyme-induced lung changes, and can also modulate hamster lung lesions.

HY-115312

Ro 18-5364	Na+/K+ ATPase	Others
Ro 18-5364 is an inhibitor of gastric H+/K+ ATPase, which has the effect of inhibiting the activity of the enzyme. Ro 18-5364 has a very strong inhibitory effect on gastric mucosal H+/K+ ATPase, and the inhibitory effect is more significant at low pH. At the same time, there is no selectivity difference between the two enantiomers of H+/K+ ATPase, and its inhibitory effect can be studied and verified by a variety of experimental methods, including inhibition of enzyme activity, proton transport, and studies on its binding.

HY-N9314

Camellianin B	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Camellianin B, a flavonoid compound, is a Camellianin A metabolite. Camellianin B has antioxidant and *angiotensin converting enzyme* (ACE)** inhibitory activities .

HY-N2266

Benzoylgomisin O	COX	Inflammation/Immunology
Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, COX-1 and COX-2 enzymes and anti-inflammatory activity .

HY-122248

Phebestin	Parasite	Others
Phebestin is a compound with antimalarial activity that has an inhibitory effect on Plasmodium and has shown good results in in vitro and in vivo experiments. It can also bind to related enzymes of Plasmodium.

HY-125341

Microginin 527	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Microginin 527 is a linear cyanobacterial peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity. Microginin 527 also exhibits inhibitory effects on protein phosphatases and leucine aminopeptidase. With an IC50 value of 31 μM, Microginin 527 is the most active component in this class of compounds .

HY-124782

HDAC8-IN-8	HDAC	Infection
HDAC8-IN-8 (15a) is an HDAC8 inhibitor, with IC₅₀ values of 23.9 μM and 268.2 μM for hHDAC8 and smHDAC8 respectively. And for hHDAC1 and hHDAC6, the IC₅₀ values are 12.1 μM and 2.9 μM respectively. HDAC8-IN-8 can be used in schistosomiasis-related research .

HY-117012

NE58018	Endogenous Metabolite	Others
NE58018 is a compound with bone resorption inhibitory activity. NE58018 exerts its effect by affecting the action of Farnesyl pyrophosphate synthase (FPPS). The structural features of NE58018 combined with aminophosphonates significantly enhance its inhibitory activity. NE58018 affects the roles of Thr201 and Tyr204 residues in substrate binding and catalysis. The interaction of NE58018 enhances the inhibitory effect on the target enzyme .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase	Inflammation/Immunology
Plipastatin A1 is a lipopeptide with enzyme inhibitory and immunosuppressive activities. Plipastatin A1 is found in Bacillus cereus and inhibits phospholipase A2 (PLA2), PLC, and PLD .

HY-113734

CM026	Aldehyde Dehydrogenase (ALDH)	Others
CM026 is a selective aldehyde dehydrogenase 1A1 inhibitor with submicromolar inhibitory activity against aldehyde dehydrogenase 1A1. Its inhibitory mechanism is related to binding to the aldehyde binding pocket and utilizing a unique glycine residue. It can be used as a chemical tool to study the role of this enzyme in disease.

HY-N2010

Methyl gallate 1 Publications Verification Gallincin; NSC 363001	Bacterial HIV Reactive Oxygen Species	Infection Cardiovascular Disease Cancer
Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and HIV-1 enzyme inhibitory activities.

HY-N9535A

(R)-tert-OMe-byakangelicin	Drug Metabolite	Metabolic Disease
(R)-tert-OMe-byakangelicin is a kind of furanocoumarin, which has inhibitory activity to liver drug metabolizing enzyme (DME) activity. (R)-tert-OMe-byakangelicin can be isolated from immature fruits of Angelica sinensis .

HY-113658

ts-SA	Endogenous Metabolite	Others
ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn(II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor .

HY-107981

LSN 3213128 1 Publications Verification	Antifolate	Cancer
LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC₅₀ of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity .

HY-126237

Acetyllovastatin	Fungal	Infection
Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against *the enzyme* acetylcholinesterase with an IC₅₀** of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines .

HY-N2472R

Medicagenic acid (Standard)	Bacterial	Infection
Medicagenic acid (Standard) is the analytical standard of Medicagenic acid. This product is intended for research and analytical applications. Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-N1510

Kaempferol 3-O-gentiobioside	Glycosidase	Metabolic Disease
Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. Kaempferol 3-O-gentiobioside possesses activity against α-glucosidase and displays carbohydrate enzyme inhibitory effect with an IC₅₀ of 50.0 µM .

HY-137954

GRL-0496	SARS-CoV	Infection
GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC₅₀ of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC₅₀ of 6.9 μM .

HY-W040286

Cinosulfuron	Herbicide Endogenous Metabolite
Cinosulfuron is a selective herbicide with excellent inhibitory activity against a variety of broadleaf weeds and is widely used in crop fields to protect the growth of crops. Cinosulfuron can effectively manage weed problems by inhibiting specific enzyme activity. Cinosulfuron is used in agriculture to increase crop yield and quality and ensure efficient use of farmland.

HY-167952

mTOR inhibitor-25	PI3K	Cancer
mTOR inhibitor-25 is an enzyme inhibitor that is more selective than PI3K and has good anticancer activity. mTOR inhibitor-25 shows strong inhibitory effects on mTOR and may be used to study leukemia, skin cancer, breast cancer, lung cancer and colon cancer. mTOR inhibitor-25 showed excellent activity in cell proliferation experiments, but its inhibitory ability on PI3K was relatively weak .

HY-N2010R

Methyl gallate (Standard)	Bacterial HIV Reactive Oxygen Species	Infection Cardiovascular Disease Cancer
Methyl gallate (Standard) is the analytical standard of Methyl gallate. This product is intended for research and analytical applications. Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. Methyl gallate also shows bacterial inhibition activity. Methyl gallate also has anti-HIV-1 and HIV-1 enzyme inhibitory activities.

HY-146699

MtTMPK-IN-5	Bacterial Thymidylate Synthase	Infection
MtTMPK-IN-5 (compound 17) is a potent M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC₅₀ value of 34 μM. MtTMPK-IN-5 combines favorable enzyme inhibitory activity with significant activity against M. tuberculosis (MIC = 12.5 μM). MtTMPK-IN-5 can be used for researching tuberculosis .

HY-P10601

αs1-CN f(143–149)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
αs1-CN f(143–149) is an orally active casein-derived peptide sequence. αs1-CN f(143–149) exhibits angiotensin-converting enzyme (ACE) inhibitory activity (IC₅₀=6.58 μM) and antihypertensive activity .

HY-N2298

Camellianin A	Apoptosis	Cancer
Camellianin A, the main flavonoid in A. nitida leaves, displays anticancer activity and angiotensin converting enzyme (ACE)-inhibitory activity. Camellianin A inhibits the proliferation of the human Hep G2 and MCF-7 cell lines and induces the significant increase of the G0/G1 cell population .

HY-N7072

Grape seed extract 1 Publications Verification	Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-105747A

Guanoxyfen nitrate N-(3-Phenoxypropyl)guanidine nitrate; (3-Phenoxypropyl)guanidine nitrate	Endogenous Metabolite	Infection Neurological Disease
Guanoxyfen (N-(3-Phenoxypropyl)guanidine) nitrate is a compound that exhibits potent inhibitory activity against the serine protease enzyme TMPRSS2, which plays a crucial role in the infectivity of coronaviruses. Guanoxyfen nitrate is also an effective inhibitor of vasoconstrictor responses to sympathetic nerve stimulation.

HY-W195984

Z57346765 1 Publications Verification	Others	Cancer
Z57346765 is a PGK1-specific inhibitor that reduces the activity of metabolic enzymes in PGK1 glycolysis and inhibits PGK1-dependent cell proliferation. Z57346765 exerts inhibitory effects against clear cell renal cell carcinoma (KIRC) .

HY-118061

VCC234718	Bacterial	Infection
VCC234718 is a molecule with mycobacterial growth inhibitory activity, specifically targeting Mycobacterium tuberculosis (Mtb). The primary molecular target of VCC234718 is inosine monophosphate dehydrogenase (GuaB2), and it inhibits the growth of Mtb by affecting the function of this enzyme. VCC234718 inhibits GuaB2 with a K value of 100 nM and exhibits non-competitive inhibition with IMP and NAD+. VCC234718 exerts its inhibitory effect by directly interacting with IMP and binding at the NAD+ site .

HY-W157689

IDE-IN-2	Proteolytic Enzyme IDE	Infection Metabolic Disease Cancer
IDE-IN-3 (Compound 4) is an inhibitor for insulin-degrading enzyme. IDE-IN-3 is predicted to have CYP3A4, CYP2C19, hERG, NADP+, HIF1α and histidine kinase inhibitory activities, and has potential biological activity in anti-diabetic, anti-tumor, anti-bacterial aspects, according to the in silico prediction .

HY-161472

Aldose reductase-IN-7	Aldose Reductase	Cancer
Aldose reductase-IN-7 (Compound 6k) targets Aldose reductase. Aldose reductase-IN-7 exhibits potent enzyme inhibitory activity (K_i = 0.186 ± 0.020 μM), showing superiority to Epalrestat (HY-66009), which is currently in clinical use. Aldose reductase-IN-7 is less cytotoxic and possesses potent anticancer activity .

HY-N1483A

Guanfu base A hydrochloride	Potassium Channel	Cardiovascular Disease
Guanfu base A hydrochloride is an antiarrhythmic alkaloid with the ability to inhibit CYP2D6 enzyme activity. Guanfu base A hydrochloride can be used to inhibit arrhythmia-related diseases. Guanfu base A hydrochloride exhibits inhibitory effects on CYP2D6 in different species of organisms, including humans, monkeys, and dogs. The biological activity of Guanfu base A hydrochloride makes it have potential clinical application value .

HY-16745A

Lascufloxacin hydrochloride KRP-AM1977 hydrochloride	Bacterial	Infection
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.

HY-118210

PHOP	FAAH	Metabolic Disease
PHOP is a fatty acid amide hydrolase (FAAH) inhibitor used to assess inhibitory activity in a fluorometric assay. PHOP can determine FAAH activity by measuring the amount of 4-pyridin-1-ylbutyric acid released by the enzyme in rat brain microsomes. PHOP demonstrates potential as a FAAH inhibitor and can directly measure FAAH activity by reversed-phase HPLC and fluorescence detection, providing a basis for the development of new inhibitors.

HY-W040286R

Cinosulfuron (Standard)	Endogenous Metabolite
Cinosulfuron (Standard) is the analytical standard of Cinosulfuron. This product is intended for research and analytical applications. Cinosulfuron is a selective herbicide with excellent inhibitory activity against a variety of broadleaf weeds and is widely used in crop fields to protect the growth of crops. Cinosulfuron can effectively manage weed problems by inhibiting specific enzyme activity. Cinosulfuron is used in agriculture to increase crop yield and quality and ensure efficient use of farmland.

HY-121382R

Gypsogenin (Standard)	Others Bacterial	Cardiovascular Disease
Cinosulfuron (Standard) is the analytical standard of Cinosulfuron. This product is intended for research and analytical applications. Cinosulfuron is a selective herbicide with excellent inhibitory activity against a variety of broadleaf weeds and is widely used in crop fields to protect the growth of crops. Cinosulfuron can effectively manage weed problems by inhibiting specific enzyme activity. Cinosulfuron is used in agriculture to increase crop yield and quality and ensure efficient use of farmland.

HY-N1510R

Kaempferol 3-O-gentiobioside (Standard)	Glycosidase	Metabolic Disease
Kaempferol 3-O-gentiobioside (Standard) is the analytical standard of Kaempferol 3-O-gentiobioside. This product is intended for research and analytical applications. Kaempferol 3-O-gentiobioside is a flavonoid isolated from C. alata leaves with antidiabetic activity. Kaempferol 3-O-gentiobioside possesses activity against α-glucosidase and displays carbohydrate enzyme inhibitory effect with an IC₅₀ of 50.0 μM .

HY-151802

CPUL1	TrxR	Cancer
CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective .

HY-110167

TFC 007	PGE synthase Ligands for Target Protein for PROTAC	Cancer
TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC₅₀ value of 83 nM). TFC-007 can be used for composing H-PGDS degradation inducer PROTAC(H-PGDS)-1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon) .

HY-13269

BMS-707035 1 Publications Verification	HIV HIV Integrase	Infection Inflammation/Immunology
BMS-707035 is a potent orally active HIV-1 integrase strand transfer inhibitor (INSTI). BMS-707035 has enzyme inhibitory with an IC₅₀ value of 3 nM. BMS-707035 also has weak CYP inhibiton and antiviral activity. BMS-707035 can be used for the research of human immunodeficiency virus-1 (HIV-1) .

HY-155114

HIV-1 inhibitor-59	HIV	Infection
HIV-1 inhibitor-59 (Compound I-5b) is a HIV-1 inhibitor, with EC₅₀s of 5.62-171 nM against the wild-type (WT) and mutant HIV-1 strains. HIV-1 inhibitor-59 has moderate RT enzyme inhibitory activity (IC₅₀: 0.094-12.0 μM) .

HY-116264

CatB-IN-1	Ser/Thr Protease	Cancer
CatB-IN-1 is an enzyme inhibitor with significant inhibitory activity against tumor invasion. CatB-IN-1 may reduce the invasiveness of tumor cells by regulating intracellular protein metabolism. CatB-IN-1 demonstrates effective anti-invasive ability in cell models and can significantly reduce the invasive ability of MCF-10A neoT cells. The structure-activity relationship study of CatB-IN-1 shows that its design can target multiple functions of cat hepsin B .

HY-125798

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid 2 Publications Verification Neu5Ac2en; DANA	Influenza Virus	Infection
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC₅₀s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity .

HY-124093

8-Deazahomofolic acid	Thymidylate Synthase Bacterial	Infection Cancer
8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC₅₀ value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors .

HY-P4641

H-Trp-Phe-OH	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice .

HY-15163A

Zotiraciclib hydrochloride	FLT3 JAK CDK	Cancer
Zotiraciclib hydrochloride is a novel small molecule multi-target enzyme inhibitor with activity in inhibiting tumor growth. Zotiraciclib hydrochloride exerts its anti-tumor effect by reducing the level of Myc through inhibiting cyclin-dependent kinase 9 (CDK9). Zotiraciclib hydrochloride may be useful for inhibiting cancers that cross the blood-brain barrier. The high protein level of MCL-1 of Zotiraciclib hydrochloride is associated with survival, suggesting that it may serve as a prognostic factor and inhibitory target in further studies .

Cat. No.	Product Name	Type

HY-W010991

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

FAPGG

Chromogenic Substrates Amino acids and Derivatives

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly (FAPGG) is a specific substrate of angiotensin converting enzyme (ACE) with a Ki of 2.546×10 ^-4 M. It is used as a chromogenic probe for quantitative detection of ACE activity. N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly can be hydrolyzed by ACE to generate N-[3-(2-furyl)acryloyl]-Phe (FAP) and Gly-Gly, and the ACE inhibitory effect is monitored by photometry. FAPGG competitively binds to the active center of ACE and is a key tool for screening ACE inhibitors such as Captopril (HY-B0368) and Dioscorin. Its reversible mechanism of action supports hypertension research and drug development targeting the renin-angiotensin system .

Cat. No.	Product Name	Target	Research Area