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Results for "

GAGs

" in MedChemExpress (MCE) Product Catalog:

33

Inhibitors & Agonists

2

Biochemical Assay Reagents

10

Peptides

2

Natural
Products

1

Click Chemistry

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-108036A
    (S)-Pro-xylane

    (S)-Hydroxypropyl tetrahydropyrantriol

    		 Biochemical Assay Reagents Others
    (S)-Pro-xylane ((S)-Hydroxypropyl tetrahydropyrantriol) is the S-enantiomer of Pro-xylane (HY-108036). Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane has potential skin anti-aging properties and is eco-friendly, biodegradable, and can be used in cosmetic research .
    (S)-Pro-xylane
  • HY-124704
    Chst15-IN-1

    		SULT Neurological Disease
    Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair .
    Chst15-IN-1
  • HY-P2727
    Chondroitinase ABC
    1 Publications Verification

    ChABC

    		 Endogenous Metabolite Neurological Disease Inflammation/Immunology
    Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Chondroitinase ABC facilitates reinnervation by degrading CS-GAGs around motoneurons. Chondroitinase ABC has the potential for the research of spinal injury .
    Chondroitinase ABC
  • HY-149906C
    Trecovirsen sodium

    GEM91 sodium

    		 HIV Infection
    Trecovirsen sodium is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.
    Trecovirsen sodium
  • HY-135197
    L-Iduronic acid sodium salt

    		Drug Intermediate Others
    L-Iduronic acid sodium salt is an important monosaccharide component of glycosaminoglycans (GAGs) such as Heparin, Heparan sulfate and Dermatan sulfate .
    L-Iduronic acid sodium salt
  • HY-P10805
    Capsid assembly inhibitor

    		HIV Infection
    Capsid assembly inhibitor is a 12-mer peptide that binds the capsid (CA) domain of Gag and inhibits assembly of immature- and mature-like HIV-1 capsid particles in vitro .
    Capsid assembly inhibitor
  • HY-150536
    EP39

    		HIV HIV Protease Infection
    EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity .
    EP39
  • HY-106586
    Ioxaglic acid

    P-286

    		 Biochemical Assay Reagents Others
    Ioxaglic acid (P-286) is negatively charged contrast agent, is useful as an inverse indicator for glycosaminoglycan (GAG) used in computed tomography (CT). Ioxaglic acid can be used for imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content .
    Ioxaglic acid
  • HY-P10562
    BMV Gag-(7−25)

    		TMV Others
    BMV Gag-(7?25) is an arginine-rich peptide with cell-penetrating ability. BMV Gag-(7?25) can be used in drug delivery and gene therapy research .
    BMV Gag-(7−25)
  • HY-P1885
    HIV gag peptide (197-205)

    		HIV Infection
    HIV gag peptide (197-205) is a H-2K d-restricted epitope derived from the p24 portion of the HIV-1 gag protein, consists of amino acids 197-205 (AMQMLKETI) .
    HIV gag peptide (197-205)
  • HY-149906
    Trecovirsen

    GEM91

    		 HIV Infection
    Trecovirsen (GEM91) is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.
    Trecovirsen
  • HY-P10301
    CXCL9(74-103)

    		CXCR Cancer
    CXCL9(74-103) is a derivative peptide of CXCL9 that has a high affinity for glycosaminoglycans (GAGs) and can bind to GAGs. CXCL9(74-103) possesses anti-angiogenic properties, capable of reducing EGF, VEGF165, and FGF-2-mediated angiogenesis processes in vitro, without exhibiting cytotoxicity .
    CXCL9(74-103)
  • HY-149906A
    FITC-Trecovirsen sodium

    FITC-GEM91 sodium

    		 HIV Infection
    FITC-Trecovirsen (sodium) is a FITC labeled Trecovirsen. Trecovirsen is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene .
    FITC-Trecovirsen sodium
  • HY-P10300
    CXCL8 (54-72)

    IL-8 (54-72)

    		 CXCR Inflammation/Immunology
    CXCL8 (54-72) is a C-terminal peptide based on the chemokine CXCL8. CXCL8 (54-72) has an interaction between a long and highly positively charged C-terminal region and a negative charge on the GAG that binds to the GAG. CXCL8 (54-72) can inhibit the adhesion and migration of neutrophils and adhesion of endothelial cells. CXCL8 (54-72) can be used to study chemokines in inflammatory response .
    CXCL8 (54-72)
  • HY-P1757
    HIV p17 Gag (77-85)

    		HIV Infection
    HIV p17 Gag (77-85) is an HLA-A*0201(A2)-restricted CTL epitope, used in the research of anti-HIV .
    HIV p17 Gag (77-85)
  • HY-E70186
    Arylsulfatase B

    EC:3.1.6.12; ARSB

    		 Biochemical Assay Reagents Others
    Arylsulfatase B (EC:3.1.6.12, ARSB) removes a chemical group known as a sulfate from two GAGs called dermatan sulfate and chondroitin sulfate .
    Arylsulfatase B
  • HY-102077
    SAMT-247

    		HIV Infection
    SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity .
    SAMT-247
  • HY-P1785
    Abl Cytosolic Substrate

    Abltide

    		 Bcr-Abl Cancer
    Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl ). Abl Protein Tyrosine Kinase (AbI) is a truncated form of the v-AbI Protein Tyrosine Kinase, a partner in the Gag-Abl fusion protein of the Abelson murine leukemia virus .
    Abl Cytosolic Substrate
  • HY-P5426
    Abl protein tyrosine kinase substrate

    		Bcr-Abl Others
    Abl protein tyrosine kinase substrate is a biological active peptide. (Abltide is a peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus. Used in Western blot and kinase assay.)
    Abl protein tyrosine kinase substrate
  • HY-139850
    GPS491

    		HIV Infection
    GPS491 (EC50 = 0.47 μM) suppresses expression of the HIV-1 structural protein Gag and alters HIV-1 RNA accumulation, decreasing the abundance of RNAs encoding the structural proteins while increasing levels of viral RNAs encoding the regulatory proteins.
    GPS491
  • HY-108036
    Pro-xylane (30% in water)

    Hydroxypropyl tetrahydropyrantriol

    		 Biochemical Assay Reagents Metabolic Disease
    Pro-xylane (30% in water) (Hydroxypropyl tetrahydropyrantriol) is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane (30% in water) has potential skin anti-aging properties and is eco-friendly, biodegradable, and can be used in cosmetic research .
    Pro-xylane (30% in water)
  • HY-N9362R
    Emodinanthrone (Standard)

    		Antibiotic Infection
    Pro-xylane (Standard) is the analytical standard of Pro-xylane. This product is intended for research and analytical applications. Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane is the first example of 'Green' chemical used in cosmetic .
    Emodinanthrone (Standard)
  • HY-P4351
    HIV-1 gag Protein p24 (194-210)

    		HIV Others
    HIV-1 gag Protein p24 (194-210) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
    HIV-1 gag Protein p24 (194-210)
  • HY-169847
    ZK-806450

    		SARS-CoV Dengue Virus Infection
    ZK-806450 is a compound with antiviral activity. ZK-806450 has a high binding potential to the allosteric binding site of the SARS-CoV-2 3CL protease. ZK-806450 can also specifically and stably bind to the GAG site of the dengue virus envelope protein .
    ZK-806450
  • HY-120764
    PF-46396

    		HIV Infection
    PF-46396 is a potent HIV-1 inhibitor with an EC50 value of 0.206 µM. PF-46396 shows antiviral activity. PF-46396 inhibits the processing of capsid (CA)/spacer peptide 1 (SP1) (p25) Gag precursor proteins and blocks maturation of the viral core particle .
    PF-46396
  • HY-131693A
    γ-Acetylenic GABA hydrochloride

    GAG hydrochloride

    		 GABA Receptor Neurological Disease Cancer
    γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride can increase the concentration of GABA in rat brain . γ-Acetylenic GABA (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    γ-Acetylenic GABA hydrochloride
  • HY-P10845
    KRL74

    		HIV Infection
    KRL74 is a cyclic peptide inhibitor for interaction between the p6 domain of the HIV Gag protein and the UEV domain of the human TSG101 protein(p6/UEV) with an IC50 of 5.44 μM and a Kd of 11.9 μM. KRL74 inhibits the budding process of HIV from host cells with an IC50 of 2 μM in virus-like particle (VLP) budding assay .
    KRL74
  • HY-N0842
    Bevirimat
    1 Publications Verification

    PA-457; MPC-4326; YK FH312

    		 Virus Protease Infection
    Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies .
    Bevirimat
  • HY-153225
    PYR01

    		HIV Reverse Transcriptase Infection
    PYR01 is a non-nucleoside reverse transcriptase inhibitor and a killing activator targeting HIV infected cells. PYR01 has cytokilling and antiviral properties of HIV-1 infection with the IC50 values of 27.5nM and 39.7nM, respectively. PYR01 leads to selective cytotoxicity by promoting HIV-1 Gag-Pol dimerization and HIV-1 protease intracellular activation. PYR01 can be used in the study of HIV .
    PYR01
  • HY-112591
    NSC260594

    		Apoptosis HIV Wnt Bcl-2 Family Cancer
    NSC260594 induces Apoptosis. NSC260594 binds the shallow groove of the Mcl-1 protein, and inhibits Mcl-1 expression through down-regulation of Wnt signaling proteins. NSC260594 can also recognize G9-G10-A11-G12 RNA tetraloop of HIV and prevent the binding of the Gag protein within the 5’-UTR. NSC260594 inhibits tumor growth, and can be used for research of Triple-negative breast cancers (TNBCs) .
    NSC260594
  • HY-116282
    Dextran sulfate sodium salt (MW 5000)
    1 Publications Verification

    DSS (MW 5000); DXS (MW 5000)

    		 HIV Complement System Apoptosis Infection Inflammation/Immunology
    Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR) .
    Dextran sulfate sodium salt (MW 5000)
  • HY-116282A
    Dextran sulfate sodium salt (MW 4500-5500)

    DSS (MW 4500-5500); DXS (MW 4500-5500)

    		 HIV Apoptosis Complement System Infection Inflammation/Immunology
    Dextran sulfate sodium salt (DSS) (MW 4500-5500) is a polymer of dehydrated glucose with a molecular weight of approximately 4500-5500. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 4500-5500) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 4500-5500) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (MW 4500-5500) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 4500-5500) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 4500-5500) inhibits instant blood-mediated inflammatory reaction (IBMIR) .
    Dextran sulfate sodium salt (MW 4500-5500)
  • HY-117747
    DMP 323

    JCR 424; XM 323

    		 HIV Protease Infection
    DMP 323 is a potent, nonpeptide cyclic urea inhibitor of HIV protease, effective against both HIV type 1 and type 2. Designed using structural information and database searching, it competitively inhibits the cleavage of both peptide and HIV-1 gag polyprotein substrates. DMP 323 shows comparable potency to other highly effective HIV protease inhibitors like A-80987 and Ro-31-8959. Importantly, its efficacy against HIV protease remains unaffected by human plasma or serum, suggesting low affinity for plasma proteins. Furthermore, DMP 323 demonstrates minimal inhibition of various mammalian proteases at concentrations much higher than those needed for HIV protease inhibition, highlighting its specificity for viral targets .
    DMP 323

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