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Results for "

Hypoglycemic activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Autophagy (2) Biochemical Assay Reagents (1) COX (2) Dipeptidyl Peptidase (1) Drug Derivative (1) Endogenous Metabolite (3) Glycosidase (7) HIF/HIF Prolyl-Hydroxylase (2) HIV (1) Influenza Virus (2) Insulin Receptor (1) Integrin (2) JAK (3) Keap1-Nrf2 (3) MMP (2) NF-κB (2) Phosphatase (4) PPAR (3) ROS Kinase (2) TRP Channel (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (5) Endocrinology (1) Infection (4) Inflammation/Immunology (13) Metabolic Disease (24) Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0004

2-Pyridinemethanol	Drug Derivative	Metabolic Disease
2-Pyridinemethanol is a pyridylalcohol, with hypoglycemic activity .

HY-15383

Glyparamide	Others	Others
Glyparamide is an orally active chlorophenyl-containing sulfonylurea. Glyparamide shows hypoglycemic activity and rarely causes hepatic injury .

HY-W011651

Carbutamide BZ-55	Phosphatase	Metabolic Disease
Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity .

HY-N0661

Alliin	Others	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities .

HY-N6653

Lentinan 5 Publications Verification	JAK Keap1-Nrf2 Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering ^[1][4].

HY-162893

SX29	Glycosidase	Metabolic Disease
SX29 is an orally active non-competitive α-glucosidase inhibitor with an IC₅₀ value of 2.12 μM. SX29 exhibits hypoglycemic activity, and oral administration of SX29 can reduce blood glucose levels and improve glucose tolerance in diabetic mice .

HY-N12241

Sterebin F	Others	Others
Sterebin F is a steroid isolated from the Stevia rebaudiana leaves. Sterebin F has hypoglycemic activity .

HY-168706

LXQ-87	Phosphatase	Metabolic Disease
LXQ-87 is an oral noncompetitive inhibitor of PTP1B with an IC₅₀ of 1.061 μM, showing hypoglycemic activity. LXQ-87 alleviates insulin resistance and promotes cellular glucose uptake, making it useful for research on type 2 diabetes .

HY-173217

PPARα agonist 5	PPAR Phosphatase	Cardiovascular Disease Metabolic Disease
PPARα agonist 5 is an orally available, selective partial agonist of PPARα (EC₅₀: 3 nM). PPARα agonist 5 reduces lipid accumulation and upregulates key PPARα target genes, exerting anti-fatty liver effects. PPARα agonist 5 also exhibits significant hypolipidemic and hypoglycemic effects through partial PPARγ agonist activity and mild inhibition of protein tyrosine phosphatase 1B (PTP1B) (IC₅₀: 79.1 μM). PPARα agonist 5 has a good safety profile and can be used in the study of type 2 diabetes with dyslipidemia .

HY-135670B

Glycosidase-IN-2	Glycosidase	Metabolic Disease
Glycosidase-IN-2 (Compound 20) is an azasugar class of glycosidase inhibitor. Glycosidase-IN-2 has hypoglycemic activity .

HY-W011651R

Carbutamide (Standard)	Phosphatase	Metabolic Disease
Carbutamide (Standard) is the analytical standard of Carbutamide. This product is intended for research and analytical applications. Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity .

HY-135670A

β-glycosidase-IN-1	Glycosidase	Metabolic Disease
β-glycosidase-IN-1 (Compound 33) is a piperidine derivative and a β-glycosidase inhibitor. β-glycosidase-IN-1 has hypoglycemic activity .

HY-N0205

Pulchinenoside C 1 Publications Verification Anemoside B4	Others	Cancer
Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity.

HY-113631

Amorfrutin B	PPAR	Neurological Disease Metabolic Disease
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with K_i values of 19 nM and EC₅₀ values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities .

HY-121565

SaRI 59-801	Insulin Receptor	Metabolic Disease Endocrinology
SaRI 59-801 is an orally effective hypoglycemic compound with stimulation activity of insulin secretion. SaRI 59-801 decreases blood glucose in several species and to elevate plasma insulin in rats and mice .

HY-N4147

Eleutheroside D	Others	Metabolic Disease Inflammation/Immunology
Eleutheroside D is an active lignan isolated from the root of Eleutherococcus senticosus, has anti-inflammatory and hypoglycemic activities . Eleutheroside D is an optical isomer of Eleutheroside E (HY-N0272) .

HY-N2000

Bellidifolin	HIV	Infection Inflammation/Immunology Cancer
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities . Bellidifolin also acts as a viral protein R (Vpr) inhibitor .

HY-N0661R

Alliin (Standard)	Others	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Alliin (Standard) is the analytical standard of Alliin. This product is intended for research and analytical applications. Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities .

HY-135670

Glycosidase-IN-1	Glycosidase	Metabolic Disease
Glycosidase-IN-1 (Compound 9) is a glycosidase inhibitor synthesized from D-mannose. Glycosidase-IN-1 be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors. Glycosidase-IN-1 has hypoglycemic activity .

HY-N0655

D-Pinitol 3-O-Methyl-D-chiro-inositol	Influenza Virus	Infection Cardiovascular Disease Inflammation/Immunology
D-pinitol (3-O-Methyl-D-chiro-inositol) is a natural compound presented in several plants, like Pinaceae and Leguminosae plants. D-pinitol exerts hypoglycemic activity and protective effects in the cardiovascular system . D-pinitol has antiviral and larvicidal activities .

HY-N0807R

Swertiamarin (Standard)	MMP NF-κB JAK Keap1-Nrf2	Metabolic Disease Inflammation/Immunology Cancer
Swertiamarin (Standard) is the analytical standard of Swertiamarin. This product is intended for research and analytical applications. Swertiamarin is an orally active iridoid compound with hypoglycemic, hypolipidemic, anti rheumatic and antioxidant activities, which can be used in the research of diabetes and arthritis .

HY-173183

α-Glucosidase-IN-87	Glycosidase	Metabolic Disease
α-Glucosidase-IN-87 (Compound 11c) is an orally active α-glucosidase inhibitor with an IC₅₀ value of 119.7 μM. α-Glucosidase-IN-87 has hypoglycemic activity and can be used in the research of metabolic diseases such as diabetes .

HY-N0299

Stachyose hydrate	Endogenous Metabolite Apoptosis	Metabolic Disease Inflammation/Immunology
Stachyose hydrate is an orally active prebiotic that enhances the growth and activity of beneficial bacteria. Stachyose hydrate has hypoglycemic effects and can improve inflammation by regulating gut microbiota. In addition, Stachyose hydrate can induce plant cell apoptosis (Apoptosis). Stachyose hydrate can be used in research on inflammation, gastrointestinal diseases, and agriculture .

HY-N0416

Cucurbitacin B Maximum Cited Publications 8 Publications Verification	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX	Others Neurological Disease Inflammation/Immunology Cancer
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-N0655R

D-Pinitol (Standard)	Influenza Virus	Infection Cardiovascular Disease Inflammation/Immunology
D-Pinitol (Standard) is the analytical standard of D-Pinitol. This product is intended for research and analytical applications. D-pinitol (3-O-Methyl-D-chiro-inositol) is a natural compound presented in several plants, like Pinaceae and Leguminosae plants. D-pinitol exerts hypoglycemic activity and protective effects in the cardiovascular system . D-pinitol has antiviral and larvicidal activities .

HY-150723

PBI-6DNJ	Glycosidase	Metabolic Disease
PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against α-glucosidase from mice, with a K_i of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-N0416R

Cucurbitacin B (Standard)	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX	Others Neurological Disease Inflammation/Immunology Cancer
Cucurbitacin B (Standard) is the analytical standard of Cucurbitacin B. This product is intended for research and analytical applications. Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

HY-163005

α-Glucosidase-IN-43	Glycosidase	Metabolic Disease
α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor (IC₅₀: 4.32 μM) with acute hypoglycemic activity. α-Glucosidase-IN-43 exhibits safety and in vivo efficacy, is nontoxic to normal mouse fibroblasts, and is able to rescue streptozotocin (HY-13753)-induced diabetic rats. α-Glucosidase-IN-43 can be used to study postprandial hyperglycemia in diabetic patients .

HY-147246

Berberine ursodeoxycholate 1 Publications Verification HTD1801; BUDCA	Biochemical Assay Reagents	Metabolic Disease
Berberine ursodeoxycholate (HTD1801), an ionic salt of Berberine and Ursodeoxycholic acid, is an orally active and potent hypolipidemic agent. Berberine ursodeoxycholate shows significantly great reduction in liver fat content. Berberine ursodeoxycholate has a broad spectrum of metabolic activity. Berberine ursodeoxycholate can be used for the research of hyperlipidemia, non-alcoholic steatohepatitis (NASH) and diabetes .

HY-I0786

(2S,4R)-Teneligliptin	Dipeptidyl Peptidase	Metabolic Disease
(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). (2S,4R)-Teneligliptin increases the plasma concentration of active glucagon-like peptide-1 (GLP-1), which promotes insulin secretion in response to elevated blood glucose levels, exerting hypoglycemic activity. (2S,4R)-Teneligliptin is promising for research of type 2 diabetes .

HY-N0807

Swertiamarin	MMP NF-κB JAK Keap1-Nrf2	Metabolic Disease Inflammation/Immunology Cancer
Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .

HY-126969

C333H	PPAR	Metabolic Disease
C333H is a selective PPARγ modulator with insulin-sensitizing and hypoglycemic activities. C333H exhibits similar insulin-sensitizing effects to thiazolidinediones (TZDs) in diabetic mouse models without significantly increasing body weight or adipose tissue weight. C333H increases circulating high molecular weight adiponectin isoform levels in diabetic db/db mice, reduces serine phosphorylation of PPARγ 273 in brown adipose tissue, and selectively modulates the expression of specific PPARγ target genes in adipose tissue. Express. C333H exhibits weak recruitment of co-activators and weak dissociation of co-repressors in vitro. These properties suggest that C333H may be a potential inhibitor of type 2 diabetes .

Alliin	Cardiovascular Disease Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields A．Sativam L. var．Viviparum Regel	Others
Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities .

Lentinan 5 Publications Verification	Structural Classification Polysaccharides Agaricaceae Classification of Application Fields Source classification Lentinus edodes (Berk. ) Sing Plants Disease Research Fields Saccharides Cancer	JAK Keap1-Nrf2 Apoptosis
Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering ^[1][4].

Pulchinenoside C 1 Publications Verification Anemoside B4	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Source classification Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Cancer	Others
Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity.

Bellidifolin	Infection Structural Classification Xanthones Classification of Application Fields Source classification Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms. ex C. B. Clark Gentianaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	HIV
Bellidifolin is a xanthone isolated from the stems of Swertia punicea, with hepatoprotective, hypoglycemic, anti-oxidation, anti-inflammatory and antitumor activities . Bellidifolin also acts as a viral protein R (Vpr) inhibitor .

D-Pinitol 3-O-Methyl-D-chiro-inositol	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Plants Inflammation/Immunology Disease Research Fields	Influenza Virus
D-pinitol (3-O-Methyl-D-chiro-inositol) is a natural compound presented in several plants, like Pinaceae and Leguminosae plants. D-pinitol exerts hypoglycemic activity and protective effects in the cardiovascular system . D-pinitol has antiviral and larvicidal activities .

Sterebin F	Structural Classification Terpenoids Source classification Cassia Diterpenoids Plants Compositae	Others
Sterebin F is a steroid isolated from the Stevia rebaudiana leaves. Sterebin F has hypoglycemic activity .

Amorfrutin B	Structural Classification Monophenols Leguminosae Source classification Phenols Amorpha fruticosaL. Plants	PPAR
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with K_i values of 19 nM and EC₅₀ values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities .

Eleutheroside D	Classification of Application Fields Source classification Lignans Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Disease Research Fields Inflammation/Immunology Araliaceae	Others
Eleutheroside D is an active lignan isolated from the root of Eleutherococcus senticosus, has anti-inflammatory and hypoglycemic activities . Eleutheroside D is an optical isomer of Eleutheroside E (HY-N0272) .

Alliin (Standard)	Structural Classification Liliaceae Ketones, Aldehydes, Acids Source classification Plants A．Sativam L. var．Viviparum Regel	Others
Alliin (Standard) is the analytical standard of Alliin. This product is intended for research and analytical applications. Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities .

Swertiamarin (Standard)	Structural Classification Monophenols other families Phenols Zanthoxylum chiloperone var. angustifolium Plants	MMP NF-κB JAK Keap1-Nrf2
Swertiamarin (Standard) is the analytical standard of Swertiamarin. This product is intended for research and analytical applications. Swertiamarin is an orally active iridoid compound with hypoglycemic, hypolipidemic, anti rheumatic and antioxidant activities, which can be used in the research of diabetes and arthritis .

Stachyose hydrate	Structural Classification Polysaccharides Classification of Application Fields Source classification Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Inflammation/Immunology Disease Research Fields Saccharides	Endogenous Metabolite Apoptosis
Stachyose hydrate is an orally active prebiotic that enhances the growth and activity of beneficial bacteria. Stachyose hydrate has hypoglycemic effects and can improve inflammation by regulating gut microbiota. In addition, Stachyose hydrate can induce plant cell apoptosis (Apoptosis). Stachyose hydrate can be used in research on inflammation, gastrointestinal diseases, and agriculture .

Cucurbitacin B Maximum Cited Publications 8 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Trichosanthes cucumerina L. Plants Endogenous metabolite Disease Research Fields Cancer	HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

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Hypoglycemic activity

Inhibitors & Agonists

NaturalProducts

Natural
Products