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Results for "

LNA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (11) E1/E2/E3 Enzyme (2) Nucleoside Antimetabolite/Analog (8) PCSK9 (4)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Metabolic Disease (4)
Oligonucleotides:	Nucleosides and their Analogs (3) Nucleoside Phosphoramidites (9) Antisense Oligonucleotides (6) Cap Analogs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand .

HY-110407

2'-O,4'-C-Methyleneadenosine LNA-A	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Metabolic Disease
2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog .

HY-W570887

LNA-A(Bz) amidite	DNA/RNA Synthesis	Others
LNA-A(Bz) amidite can be used for synthesis of ASOs (antisense oligonucleotides) .

HY-W570888

2'-O,4'-C-Methylenecytidine LNA-C(Bz)	Nucleoside Antimetabolite/Analog	Cancer
2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands .

HY-W570892

*DMTr-LNA-U-3-CED-Phosphora*	DNA/RNA Synthesis	Others
DMTr-LNA-U-3-CED-phosphora is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-111531

*DMTr-LNA-5MeU-3-CED-phosphoramidite*	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative .

HY-148506

5'-ODMT cEt m5U Phosphoramidite (Amidite)	Nucleoside Antimetabolite/Analog	Cardiovascular Disease
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice .

HY-W570893

*DMT-LNA-G phosphoramidite*	DNA/RNA Synthesis	Others
DMT-LNA-G phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-W570891

*DMTr-LNA-C(Bz)-3-CED-phosphoramidite*	Nucleoside Antimetabolite/Analog	Cancer
DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-111807

Locked nucleic acid 1	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Metabolic Disease
Locked nucleic acid 1 is a derivative of LNA-type nucleoside.

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)	Nucleoside Antimetabolite/Analog	Cancer
5'-ODMT cEt N-Bz A Phosphoramidite Amidite is a locked nucleic acid (LNA) analogue. 5'-ODMT cEt N-Bz A Phosphoramidite Amidite possesses hybridization and mismatch discrimination attributes similar to those of LNA and shows resistance to exonuclease digestion .

HY-W570889

*DMT-LNA-5mA phosphoramidite*	DNA/RNA Synthesis	Others
(1R,3R,4R,7S)-3-(4-Amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-148689

SPC4061	PCSK9	Metabolic Disease
SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases .

HY-148689A

SPC4061 sodium	PCSK9	Metabolic Disease
SPC4061 an antisense nucleotide, sodium is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases .

HY-46317

DMT-5Me-dC(Bz)-CE Phosphoramidite	DNA/RNA Synthesis	Others
DMT-5Me-dC(Bz)-CE Phosphoramidite is used in the preparation of locked nucleic acids (LNAs) for optimization of fluorescent oligonucleotide probes with improved spectral properties and target binding .

HY-148687

SPC5001	PCSK9	Cardiovascular Disease
SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .

HY-148687A

SPC5001 sodium	PCSK9	Cardiovascular Disease
SPC5001 sodium is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 sodium can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium	E1/E2/E3 Enzyme	Others
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148130

Rugonersen RG6091; RO7248824	E1/E2/E3 Enzyme	Others
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-145973A

3'OMe-m7GpppAmpG (ammonium) solution (100mM) m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100mM)	DNA/RNA Synthesis	Others
3'OMe-m7GpppAmpG ammonium solution (100mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

HY-145973

3'OMe-m7GpppAmpG m7(3'OMeG)(5')ppp(5')(2'OMeA)pG	DNA/RNA Synthesis	Others
3'OMe-m7GpppAmpG is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG shows a significant translational efficiency. 3'OMe-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

Cat. No.	Product Name	Type

HY-145973A

3'OMe-m7GpppAmpG (ammonium) solution (100mM) m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100mM)	Gene Sequencing and Synthesis
3'OMe-m7GpppAmpG ammonium solution (100mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

Cat. No.	Product Name		Classification

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G		Nucleosides and their Analogs
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand .

HY-110407

2'-O,4'-C-Methyleneadenosine LNA-A		Nucleosides and their Analogs
2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog .

HY-W570887

LNA-A(Bz) amidite		Nucleoside Phosphoramidites
LNA-A(Bz) amidite can be used for synthesis of ASOs (antisense oligonucleotides) .

HY-W570892

*DMTr-LNA-U-3-CED-Phosphora*		Nucleoside Phosphoramidites
DMTr-LNA-U-3-CED-phosphora is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-111531

*DMTr-LNA-5MeU-3-CED-phosphoramidite*		Nucleoside Phosphoramidites
DMTr-LNA-5MeU-3-CED-phosphoramidite is a nucleoside derivative .

HY-148506

5'-ODMT cEt m5U Phosphoramidite (Amidite)		Nucleoside Phosphoramidites
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice .

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)		Nucleoside Phosphoramidites
5'-ODMT cEt N-Bz A Phosphoramidite Amidite is a locked nucleic acid (LNA) analogue. 5'-ODMT cEt N-Bz A Phosphoramidite Amidite possesses hybridization and mismatch discrimination attributes similar to those of LNA and shows resistance to exonuclease digestion .

HY-W570893

*DMT-LNA-G phosphoramidite*		Nucleoside Phosphoramidites
DMT-LNA-G phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-W570891

*DMTr-LNA-C(Bz)-3-CED-phosphoramidite*		Nucleoside Phosphoramidites
DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-111807

Locked nucleic acid 1		Nucleosides and their Analogs
Locked nucleic acid 1 is a derivative of LNA-type nucleoside.

HY-W570889

*DMT-LNA-5mA phosphoramidite*		Nucleoside Phosphoramidites
(1R,3R,4R,7S)-3-(4-Amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-148689

SPC4061		Antisense Oligonucleotides
SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases .

HY-148689A

SPC4061 sodium		Antisense Oligonucleotides
SPC4061 an antisense nucleotide, sodium is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases .

HY-46317

DMT-5Me-dC(Bz)-CE Phosphoramidite		Nucleoside Phosphoramidites
DMT-5Me-dC(Bz)-CE Phosphoramidite is used in the preparation of locked nucleic acids (LNAs) for optimization of fluorescent oligonucleotide probes with improved spectral properties and target binding .

HY-148687

SPC5001		Antisense Oligonucleotides
SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .

HY-148687A

SPC5001 sodium		Antisense Oligonucleotides
SPC5001 sodium is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 sodium can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium		Antisense Oligonucleotides
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148130

Rugonersen RG6091; RO7248824		Antisense Oligonucleotides
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-145973A

3'OMe-m7GpppAmpG (ammonium) solution (100mM) m7(3'OMeG)(5')ppp(5')(2'OMeA)pG ammonium solution (100mM)		Cap Analogs
3'OMe-m7GpppAmpG ammonium solution (100mM) is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG ammonium shows a significant translational efficiency. 3'OMe-m7GpppAmpG ammonium can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

HY-145973

3'OMe-m7GpppAmpG m7(3'OMeG)(5')ppp(5')(2'OMeA)pG		Cap Analogs
3'OMe-m7GpppAmpG is a trinucleotide Cap analogue. 3'OMe-m7GpppAmpG shows a significant translational efficiency. 3'OMe-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization .

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