LY6

By Targets:	p38 MAPK (1) Phosphatase (1) SHP2 (1) Small Interfering RNA (siRNA) (9)
By Research Areas:	Cancer (3) Inflammation/Immunology (1)
Oligonucleotides:	Pre-designed siRNA Sets (9) siRNAs (9)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125257

SHP2 inhibitor LY6 LY6	SHP2 Phosphatase	Cancer
SHP2 inhibitor LY6 (LY6) is potent and selective inhibitor of SHP2, with an IC₅₀ of 9.8 µM. SHP2 inhibitor LY6 can inhibits SHP2-mediated cell signaling and proliferation .

HY-RS07903

LY6L Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6L Human Pre-designed siRNA Set A contains three designed siRNAs for LY6L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6L Human Pre-designed siRNA Set A LY6L Human Pre-designed siRNA Set A

HY-RS07896

LY6D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6D Human Pre-designed siRNA Set A contains three designed siRNAs for LY6D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6D Human Pre-designed siRNA Set A LY6D Human Pre-designed siRNA Set A

HY-RS07897

LY6E Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6E Human Pre-designed siRNA Set A contains three designed siRNAs for LY6E gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6E Human Pre-designed siRNA Set A LY6E Human Pre-designed siRNA Set A

HY-RS07901

LY6H Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6H Human Pre-designed siRNA Set A contains three designed siRNAs for LY6H gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6H Human Pre-designed siRNA Set A LY6H Human Pre-designed siRNA Set A

HY-RS07902

LY6K Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6K Human Pre-designed siRNA Set A contains three designed siRNAs for LY6K gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6K Human Pre-designed siRNA Set A LY6K Human Pre-designed siRNA Set A

HY-RS07904

LY6S Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6S Human Pre-designed siRNA Set A contains three designed siRNAs for LY6S gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6S Human Pre-designed siRNA Set A LY6S Human Pre-designed siRNA Set A

HY-RS07898

LY6G6C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6G6C Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6G6C Human Pre-designed siRNA Set A LY6G6C Human Pre-designed siRNA Set A

HY-RS07899

LY6G6D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6G6D Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6G6D Human Pre-designed siRNA Set A LY6G6D Human Pre-designed siRNA Set A

HY-RS07900

LY6G6F Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LY6G6F Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6F gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LY6G6F Human Pre-designed siRNA Set A LY6G6F Human Pre-designed siRNA Set A

HY-123885

NSC243928 mesylate	Others	Cancer
NSC243928 mesylate is a human lymphocyte antigen 6 (LY6) binder, which also acts as an inhibitor of cell growth and has anticancer activity .

HY-125980

LX-3	p38 MAPK	Cancer
LX-3 is a selective activator of the p38 MAPK signaling pathway and activates EGFP reporter genes that are silenced by DNA methylation, such as TNF, EGR1, LY6K, and ISG20 .

Cat. No.	Product Name	Target	Research Area

HY-P99142

*Anti-Mouse Ly-6G/Ly-6C Antibody (RB6-8C5)* 1 Publications Verification	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse Ly-6G/Ly-6C Antibody is an anti-mouse Ly-6G/Ly-6C IgG2b antibody inhibitor.

HY-P990200

*Anti-Mouse Ly6C Antibody (Monts 1)*	Inhibitory Antibodies	Others
Anti-Mouse Ly6C Antibody (Monts 1) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse Ly6C.

HY-P990118

*Anti-Mouse Ly6G Antibody (1A8)*	Inhibitory Antibodies	Others
Anti-Mouse Ly6G Antibody (1A8) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse Ly6G.

HY-P990199

*Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14)*	Inhibitory Antibodies	Others
Anti-Mouse Ly6G/Ly6C Antibody (NIMP-R14) is a rat-derived IgG2b, κ type antibody inhibitor, targeting to mouse Ly6G/Ly6C.

Species:	Human (7) Mouse (6) Cynomolgus (3)
Tag:	His (13) SUMO (2) Fc (3)
Source:	HEK293 (8) P. pastoris (6) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701021

	LY6G6F Protein, Human (HEK293, hFc) C6orf21; G6F; LY6G6D; NG32	Human	HEK293
	LY6G6F protein participates in signal transduction pathways involving GRB2 and GRB7. Forming homodimers and interacting with GRB2 and GRB7 in a phosphorylation-dependent manner, LY6G6F likely modulates signal transduction cascades, suggesting its involvement in intricate cellular signaling networks. LY6G6F Protein, Human (HEK293, hFc) is the recombinant human-derived LY6G6F protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LY6G6F Protein, Human (HEK293, hFc) is 219 a.a., with molecular weight of 53-63 kDa.

HY-P71751

	LY6G6D Protein, Human (P.pastoris, His) LY66D_HUMAN; LY6g6d; LYmphocyte antigen 6 complex locus protein G6d; Megakaryocyte-enhanced gene transcript 1 protein; Protein LY6-D	Human	P. pastoris
	LY6G6D Protein is a leukocyte antigen-6 (LY6) gene cluster located in the Major Histocompatibility complex (MHC) Class III region of chromosome 6. LY6G6D Protein is involved in the JAK-STAT5 and RAS-MEK-ERK signaling pathways, and is a selective expression of colorectal cancer antigen. Therapeutic T-cell responses can be targeted through T-cell adaptors. LY6G6D Protein, Human (P.pastoris, His) is the recombinant human-derived LY6G6D protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of LY6G6D Protein, Human (P.pastoris, His) is 85 a.a., with homodimer molecular weight of 11 & 22 kDa, respectively.

HY-P75920

	*Lymphocyte antigen 6A-2/LY6A Protein, Mouse (His)* LYmphocyte antigen 6A-2/6E-1; LY-6A.2/LY-6E.1; SCA-1; TAP; LY6	Mouse	E. coli
	Lymphocyte antigen 6A-2/LY6A Protein, crucial for T-cell activation, plays a key role in immune responses. Its ability to facilitate T-cell activation underscores its importance in regulating T-cell responses and immune surveillance. The molecular interactions and signaling pathways in which LY6A participates during T-cell activation highlight its significance as a key orchestrator in immune responses, contributing to immune homeostasis. Lymphocyte antigen 6A-2/LY6A Protein, Mouse (His) is the recombinant mouse-derived Lymphocyte antigen 6A-2/LY6A protein, expressed by E. coli , with N-His labeled tag. The total length of Lymphocyte antigen 6A-2/LY6A Protein, Mouse (His) is 93 a.a., with molecular weight of ~10.9 kDa.

HY-P71801

	*Lymphocyte antigen 6G/LY6G Protein, Mouse (P.pastoris)* LY6g; LYmphocyte antigen 6G; LY-6G; LY-6G.1	Mouse	P. pastoris
	Lymphocyte antigen 6G/LY6G protein is uniquely expressed in bone marrow, indicating its involvement in the hematopoietic microenvironment. This suggests a role in regulating immune cell development or function within the bone marrow niche. Lymphocyte antigen 6G/LY6G Protein, Mouse (P.pastoris) is the recombinant mouse-derived Lymphocyte antigen 6G/LY6G protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Lymphocyte antigen 6G/LY6G Protein, Mouse (P.pastoris) is 93 a.a., with molecular weight (glycosylation form) of ~34 kDa.

HY-P702582

	LY6D Protein, Human (HEK293, Fc) LY-6D; LYmphocyte antigen 6 complex; locus D	Human	HEK293

HY-P700473

	LY6G6D Protein, Macaca fascicularis (P. pastoris, His) Protein LY6-D; Megakaryocyte-enhanced gene transcript 1 protein; G6D; NG25; LY6-D; MEGT1; C6orf23	Cynomolgus	P. pastoris

HY-P703709

	LY6G6D Protein, Cynomolgus (HEK293, hFc)	Cynomolgus	HEK293

HY-P703738

	LY6G6D Protein Protein, Cynomolgus (HEK293, His)	Cynomolgus	HEK293

HY-P702622

	LY6G6D Protein, Mouse (HEK293, His) LYmphocyte antigen 6 complex locus protein G6d; Ng25	Mouse	HEK293
	LY6G6D Protein, Mouse (HEK293, His) is the recombinant mouse-derived LY6G6D, expressed by HEK293 , with N-His labeled tag. ,

HY-P71724

	CD59 Protein, Human (P.pastoris, His) 1F5 ; 1F5 antigen; Human leukocyte antigen MIC11; LY 6 like protein; MAC-IP; MACIF; MACIP; MEM43; MEM43 antigen	Human	P. pastoris
	The CD59 protein is a potent inhibitor of the complement membrane attack complex (MAC) and binds to assembled C8 and/or C9 complement, preventing the incorporation of multiple C9 copies that are critical for permeability pore formation. Its species-specific inhibitory effects extend to T cell activation, complexing with protein tyrosine kinases for signal transduction. CD59 Protein, Human (P.pastoris, His) is the recombinant human-derived CD59 protein, expressed by P. pastoris , with N-His labeled tag. The total length of CD59 Protein, Human (P.pastoris, His) is 77 a.a., with molecular weight of ~11.0 kDa.

HY-P70217

	*Lymphocyte antigen 6H/LY6H Protein, Human (HEK293, His)* rHuLYmphocyte antigen 6H/LY6H, His; LYmphocyte Antigen 6H; LY-6H; LY6H	Human	HEK293
	LY6H mediates the myelin trophic and neurotrophic effects of PSAP/Prosaposin protein through GPR37 and GPR37L1 receptors. Ligand-mediated internalization of these receptors results in ERK phosphorylation signaling. Lymphocyte antigen 6H/LY6H Protein, Human (HEK293, His) is the recombinant human-derived Lymphocyte antigen 6H/LY6H protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Lymphocyte antigen 6H/LY6H Protein, Human (HEK293, His) is 90 a.a., with molecular weight of ~18.0 kDa.

HY-P71796

	*Lymphocyte antigen 6C1/LY6C1 Protein, Mouse (P.pastoris, His)* LY6c1; LYmphocyte antigen 6C1; LY-6C1	Mouse	P. pastoris
	Lymphocyte antigen 6C1 enables acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity.Lymphocyte antigen 6C1 is involved in acetylcholine receptor signaling pathway.Lymphocyte antigen 6C1/LY6C1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Lymphocyte antigen 6C1/LY6C1 protein, expressed by P.pastoris , with N-6*His labeled tag.

HY-P71830

	*Lymphocyte antigen 6E/LY6E Protein, Mouse (P.pastoris, His, SUMO)* LY6e; LY67; Sca-2; Tsa-1LYmphocyte antigen 6E; LY-6E; Stem cell antigen 2; Thymic shared antigen 1; TSA-1	Mouse	P. pastoris
	LY6E is a GPI-anchored cell surface protein that regulates T lymphocyte function by binding to CD3Z/CD247, affecting proliferation, differentiation and activation.It modulates T cell receptor signaling and exhibits antiviral activity against mouse hepatitis virus.Lymphocyte antigen 6E/LY6E Protein, Mouse (P.pastoris, His, SUMO) is the recombinant mouse-derived Lymphocyte antigen 6E/LY6E protein, expressed by P.pastoris , with N-His, N-SUMO labeled tag.

HY-P71539

	*Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO)* LY6E; 9804; RIGE; SCA2; TSA1; LYmphocyte antigen 6E; LY-6E; Retinoic acid-induced gene E protein; RIG-E; Stem cell antigen 2; SCA-2; Thymic shared antigen 1; TSA-1	Human	E. coli
	Lymphocyte antigen 6E/LY6E protein is a GPI-anchored cell surface regulator that regulates T cell receptor signaling through interaction with CD3Z/CD247. It limits the entry of human coronaviruses, serves as the primary receptor for syncytin-A, and may modulate nicotinic acetylcholine receptor activity. Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO) is the recombinant human-derived Lymphocyte antigen 6E/LY6E protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P76483

	LYPD3/C4.4A Protein, Mouse (HEK293, His) LY6/PLAUR domain-containing protein 3; GPI-anchored metastasis-associated protein C4.4A homolog	Mouse	HEK293
	The LYPD3/C4.4A protein is a multifunctional cell surface molecule that is critical for cell migration and has been implicated in potential tumor progression. It binds laminin 1 and laminin 5, emphasizing its role in extracellular matrix interactions. LYPD3/C4.4A Protein, Mouse (HEK293, His) is the recombinant mouse-derived LYPD3/C4.4A protein, expressed by HEK293 , with C-His labeled tag.

HY-P70219

	LYPD3/C4.4A Protein, Human (HEK293, His) rHuLY6/PLAUR domain-containing protein 3, His; LY6/PLAUR Domain-Containing Protein 3; GPI-Anchored Metastasis-Associated Protein C4.4A Homolog; Matrigel-Induced Gene C4 Protein; MIG-C4; LYPD3; C4.4A	Human	HEK293
	LYPD3/C4.4A protein facilitates cell migration and potentially influences urothelial cell-matrix interactions.It plays a role in tumor progression, binding to laminin-1 and laminin-5.Interactions with LGALS3, AGR2, and AGR3 emphasize its functional associations and impact in diverse biological processes.LYPD3/C4.4A Protein, Human (HEK293, His) is the recombinant human-derived LYPD3/C4.4A protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81353

	LYPD3 Antibody (YA1098) LYPD3; C4.4A; UNQ491/PRO1007; LY6/PLAUR domain-containing protein 3; GPI-anchored metastasis-associated protein C4.4A homolog; Matrigel-induced gene C4 protein (MIG-C4)	IHC-P	Human
	LYPD3 Antibody (YA1098) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1098), targeting LYPD3. LYPD3 Antibody (YA1098) can be used for IHC-P experiment in human background.

HY-P82773

	Ly6A/E Antibody (YA2518) LY-6A.2/LY-6E.1; LY6a; LY6al; LYmphocyte antigen 6A-2/6E-1; LYmphocyte antigen LY 6A.2/LY 6E.1; SCA-1; Stem cell antigen 1; T cell activating protein; TAP	WB, IHC-P	Mouse
	Ly6A/E Antibody (YA2518) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2518), targeting Ly6A/E, with a predicted molecular weight of 14 kDa (observed band size: 18 kDa). Ly6A/E Antibody (YA2518) can be used for WB, IHC-P experiment in mouse background.

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Cat. No.	Product Name		Classification

HY-RS07903

LY6L Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6L Human Pre-designed siRNA Set A contains three designed siRNAs for LY6L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07896

LY6D Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6D Human Pre-designed siRNA Set A contains three designed siRNAs for LY6D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07897

LY6E Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6E Human Pre-designed siRNA Set A contains three designed siRNAs for LY6E gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07901

LY6H Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6H Human Pre-designed siRNA Set A contains three designed siRNAs for LY6H gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07902

LY6K Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6K Human Pre-designed siRNA Set A contains three designed siRNAs for LY6K gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07904

LY6S Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6S Human Pre-designed siRNA Set A contains three designed siRNAs for LY6S gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07898

LY6G6C Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6G6C Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07899

LY6G6D Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6G6D Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07900

LY6G6F Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
LY6G6F Human Pre-designed siRNA Set A contains three designed siRNAs for LY6G6F gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

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Oligonucleotides