Search Result

Isoforms Recommended:	MMP-2

Results for "

MMP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Amyloid-β (1) Antibiotic (1) Apoptosis (21) Atg8/LC3 (1) Autophagy (2) Bacterial (3) Biochemical Assay Reagents (1) c-Met/HGFR (1) Chloride Channel (2) Cholinesterase (ChE) (1) COX (4) Deubiquitinase (1) ERK (4) FAK (2) Fluorescent Dye (2) HIV (3) HIV Protease (3) Isotope-Labeled Compounds (1) JNK (3) Microtubule/Tubulin (1) MMP (79) mTOR (3) NF-κB (3) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (2) p38 MAPK (1) PI3K (2) Pyroptosis (2) Reactive Oxygen Species (4) SARS-CoV (3) Small Interfering RNA (siRNA) (3) Src (1) STAT (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (68) Cardiovascular Disease (10) Endocrinology (1) Infection (5) Inflammation/Immunology (19) Metabolic Disease (5) Neurological Disease (6)
Oligonucleotides:	Nucleosides and their Analogs (1) Pre-designed siRNA Sets (3) siRNAs (3)

104

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112546

MMP-2 Inhibitor I	MMP	Cancer
MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor with a K_i of 1.7 μM .

HY-146754

MMP2-IN-1 1 Publications Verification	MMP Apoptosis	Cancer
MMP2-IN-1 is a moderate potenet *MMP2* inhibitor with IC₅₀ of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis .

HY-147746

MMP2-IN-3	MMP	Cancer
MMP2-IN-3 (compound 2) is a potent *MMP-2* (matrix metalloproteinases) inhibitor, with an IC₅₀ of 31 μM. MMP2-IN-3 also shows inhibitory activity against *MMP-9* and *MMP-8, with IC₅₀* values of 26.6, and 32 μM, respectively .

HY-147745

MMP2-IN-2	MMP	Cancer
MMP2-IN-2 (compound 42) is a potent and selective *MMP-2* (matrix metalloproteinases) inhibitor, with an IC₅₀ of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against *MMP-13, MMP-9* and *MMP-8, with IC₅₀* values of 12, 23.3, and 25 μM, respectively .

HY-116399

MMP-2/MMP-9-IN-1	MMP	Cancer
MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and *MMP-2) inhibitor with IC₅₀s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP*-9-IN-1 can be used for the research of cancer .

HY-130076

MMP-2 Inhibitor II	MMP	Cancer
MMP-2 Inhibitor II (compound 2) is a selective *MMP-2* inhibitor. The Kinetic parameters for MMP inhibition are 2.4 μM (MMP-2), 45 μM (MMP-1), and 379 μM (MMP-7), respectively .

HY-RS08537

MMP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MMP2 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP2 Human Pre-designed siRNA Set A MMP2 Human Pre-designed siRNA Set A

HY-RS08538

Mmp2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp2 Mouse Pre-designed siRNA Set A Mmp2 Mouse Pre-designed siRNA Set A

HY-RS08539

Mmp2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp2 Rat Pre-designed siRNA Set A Mmp2 Rat Pre-designed siRNA Set A

HY-161707

MMP2-IN-4	MMP	Cancer
MMP2-IN-4 (compound 3h) is a potent *MMP2* inhibitor. MMP2-IN-4 inhibits *MMP2, MMP9* and *MMP12* with IC₅₀s of 266.74, 402.75 and 1237.39 nM, respectively .

HY-147867

MMP-2/9-IN-1	MMP	Cancer
MMP-2/9-IN-1 (Compound 4a) is a potent dual *MMP-2* and *MMP-9* inhibitor with IC₅₀ values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation .

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) ^[2] .

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) ^[2] .

HY-123130

ABT-770	MMP	Cancer
ABT-770 (compound 11) is a highly selective and orally active *MMP* inhibitor, demonstrating over 1000-fold selectivity for *MMP-2* (IC₅₀=4 nM) compared to *MMP-1* (IC₅₀=4600 nM). ABT-770 can be utilized in studies related to tumor growth, invasion, and metastasis .

HY-148571

TP0597850	MMP	Inflammation/Immunology Cancer
TP0597850 is a selective inhibitor of *MMP2* (IC₅₀=0.22 nM). TP0597850 has a long *MMP2* dissociation half-life (t_1/2=265 min) .

HY-131417

cis-ACCP	MMP	Infection Cardiovascular Disease Inflammation/Immunology Cancer
cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC₅₀ values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases .

HY-168560

MMP Inhibitor 4	MMP	Cancer
MMP Inhibitor 4 (compound 4 B) is a potent *MMP* inhibitor. MMP Inhibitor 4 shows antiproliferative activity. MMP Inhibitor 4 induces cell cycle arrest at subG1 phase. MMP Inhibitor 4 decreases the mRNA expression of MMP2, MMP9 and VEGFA .

HY-119110

LY52	MMP	Cancer
LY52 is an *MMP-2* and *MMP-9* inhibitor. LY52 can significantly block the proteolytic activity of gelatinases, reducing the expression of *MMP-2* and *MMP-9* in SKOV3 cells, thereby inhibiting cell invasion. LY52 can also suppress the pulmonary metastasis of Lewis lung carcinoma cells in mice. LY52 may be used in cancer research .

HY-N0532

Morroniside	MMP Pyroptosis Apoptosis	Neurological Disease Metabolic Disease
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

HY-P3477

Mca-PLA-Nva-Dap(Dnp)-AR-NH2	Fluorescent Dye	Others
Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-168605

DH-18	MMP Apoptosis	Cancer
DH-18 is a matrix metalloproteinase-2 (MMP-2) inhibitor with the IC₅₀ values of 139.45 nM, 518.11 nM and 833.34 nM for *MMP-2, MMP-9* and *MMP-8, respectively. DH-18 induces cell apoptosis* and arrests cell cycle in the G0/G1 phase. DH-18 inhibits cell growth and can be used for study of chronic myeloid leukemia .

HY-P0273

Histatin 5	MMP	Inflammation/Immunology
Histatin 5 inhibits the activity of the host matrix metalloproteinases *MMP-2* and *MMP-9* with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-N10176

D-Isofloridoside	Reactive Oxygen Species MMP	Cardiovascular Disease
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 ^[2].

HY-P0273A

Histatin 5 TFA	MMP	Inflammation/Immunology
Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases *MMP-2* and *MMP-9* with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-124341

ND-378	MMP	Neurological Disease
ND-378 is a potent and selective inhibitor of matrix metalloproteinases (MMP-2) with a K_i value of 230 nM. ND-378 can be used to study spinal cord injury (SCI) .

HY-103444

ARP-100	MMP	Cancer
ARP-100 is a potent and selective matrix metalloproteinase *MMP-2* inhibitor (IC₅₀=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) ^[2].

HY-P4574

VPLSLYSG	MMP	Others
VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), *MMP-1* and *MMP-2. VPLSLYSG has potential applications in MMP* substrates ^[2] .

HY-162038

RXP03	MMP	Others
RXP03 is a *MMPs* inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .

HY-13564

Batimastat 5+ Cited Publications BB94	MMP	Cancer
Batimastat is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-13564A

Batimastat sodium salt BB-94 sodium salt	MMP	Cancer
Batimastat sodium salt is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-W068119A

N-(2-Aminoethyl)maleimide hydrochloride 2-Maleimidoethylamine hydrochloride	Biochemical Assay Reagents	Cancer
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a cross-linker. N-(2-Aminoethyl)maleimide hydrochloride can be used to prepare MMP-2 sensitive nanosystem, and for cancer research .

HY-122022

JR-AB2-011 10+ Cited Publications	mTOR	Cancer
JR-AB2-011 is a selective *mTORC2* inhibitor with an IC₅₀ value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (K_i: 0.19 μM) ^[1].JR-AB2-011 decreases the phosphorylation level of Akt, decreases *MMP2* activity, thereby reducing the ability of tumor cells to migrate and invade. JR-AB2-011 also induces non-apoptotic cell death ^[2].

HY-N0431

Astragaloside IV 15+ Cited Publications	MMP ERK JNK	Cancer
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of *ERK1/2* and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-W277900

2-Methoxy-2,4-diphenylfuran-3-one	MMP	Inflammation/Immunology Cancer
2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading *MMP-2* and *MMP-9* by zymography .

HY-N0532R

Morroniside (Standard)	MMP Pyroptosis Apoptosis	Neurological Disease Metabolic Disease
Morroniside (Standard) is the analytical standard of Morroniside. This product is intended for research and analytical applications. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

HY-154698

Homouridine	Nucleoside Antimetabolite/Analog	Cancer
Homouridine, is an uridine analogue. Homouridine serves as an intermediate to prepare *MMP-2* inhibitor (compund I, IC₅₀=150 μM). Homouridine derivate (compund I) also inhibits TNF-α binding to TNF-αR1 .

HY-114396

BR351	MMP	Cancer
BR351 is a brain penetrant *MMP* inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively .

HY-106992

S 3304	MMP	Cancer
S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for *MMP-2* and *MMP-9*. S 3304 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-18694

CGS 27023A	MMP	Inflammation/Immunology
CGS 27023A is a non-peptidic and orally active *MMP* inhibitor with the K_i values of 43, 33, 20 and 8 nM for MMP-3, MMP-1, MMP-2 amd MMP-9, respectively. CGS 27023A can be used for study of arthritis .

HY-W011085

CP-471474	MMP	Inflammation/Immunology
CP-471474 is an orally active and pan *MMP* inhibitor, with IC₅₀ values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively ^[2].

HY-101535

ARP101	Atg8/LC3 MMP	Cancer
ARP101 is a potent and selective inhibitor matrix metalloproteinase-2 (MMP-2). ARP101 induces autophagy-associated cell death in cancer cells. ARP101 is effective in inducing the formation of autophagosome and conversion of LC3I into LC3II .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the *Erk1/2, MMP-2* and *MMP-9* ^[2].

HY-P3513A

β-Neo-Endorphin acetate	ERK MMP	Neurological Disease
β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the *Erk1/2, MMP-2* and *MMP-9* ^[2].

HY-136699

Excisanin A	Others	Cancer
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dye	Others
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2), *MMP-7* and *MMP-9*. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues ^[2].

HY-35513

3-Aminobenzene-1,2-diol	MMP	Cancer
3-Aminobenzene-1,2-diol (compound C8) is a matrix metalloproteinase (MMP) inhibitor with IC₅₀ values of 20, 26, 16 and 16.3 μM for MMP-2, MMP-8, MMP-9 and MMP-14, respectively .

HY-124373

ND-336	MMP	Metabolic Disease
ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, *MMP-9, and MMP-14, with K_i*s of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound ^[2].

HY-14240

PG 116800 PG 530742; PGE 530742; PGE 7113313	MMP	Inflammation/Immunology
PG 116800 (PG 530742) is an orally avtive *MMP* inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research .

Cat. No.	Product Name	Type

HY-131498

MOCAc-PLGL(Dpa)AR Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	Fluorescent Dyes/Probes
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2), *MMP-7* and *MMP-9*. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues ^[2].

HY-W277900

2-Methoxy-2,4-diphenylfuran-3-one	Fluorescent Dyes/Probes
2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading *MMP-2* and *MMP-9* by zymography .

Cat. No.	Product Name	Type

HY-W068119A

N-(2-Aminoethyl)maleimide hydrochloride 2-Maleimidoethylamine hydrochloride	Biochemical Assay Reagents
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a cross-linker. N-(2-Aminoethyl)maleimide hydrochloride can be used to prepare MMP-2 sensitive nanosystem, and for cancer research .

HY-W001925

7-Methoxy-1-tetralone

Biochemical Assay Reagents

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index .

Cat. No.	Product Name	Target	Research Area

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) ^[2] .

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P0273A

Histatin 5 TFA	MMP	Inflammation/Immunology
Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases *MMP-2* and *MMP-9* with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-P10143

MMP-2/MMP-9 Substrate	Peptides	Others
MMP-2/MMP-9 Substrate, a synthetic colorimetric substrate, is a peptide .

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) ^[2] .

HY-P2689

DNP-PLGMWSR	Peptides	Others
DNP-PLGMWSR is a? fluorogenic substrate for *MMP-2 and MMP*-9 .

HY-P3477

Mca-PLA-Nva-Dap(Dnp)-AR-NH2	Fluorescent Dye	Others
Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P0273

Histatin 5	MMP	Inflammation/Immunology
Histatin 5 inhibits the activity of the host matrix metalloproteinases *MMP-2* and *MMP-9* with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-P4574

VPLSLYSG	MMP	Others
VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), *MMP-1* and *MMP-2. VPLSLYSG has potential applications in MMP* substrates ^[2] .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the *Erk1/2, MMP-2* and *MMP-9* ^[2].

HY-P5380

TNO211 Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2	MMP	Others
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0532

Morroniside	Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	MMP Pyroptosis Apoptosis
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

HY-N0431

Astragaloside IV Maximum Cited Publications 18 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Cancer	MMP ERK JNK
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of *ERK1/2* and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Solanaceae Plants Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity ^[2].

HY-N5136

25(R,S)-Ruscogenin	Liliaceae Microorganisms Classification of Application Fields Source classification Liriope platyphylla Wang et Tang Plants Disease Research Fields Steroids Cancer	Apoptosis PI3K Akt mTOR
Ruscogenin suppresses HCC metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF and HIF-1α via regulating the PI3K/Akt/mTOR signaling pathway . And Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by su

HY-W001925

7-Methoxy-1-tetralone	Structural Classification Juglandaceae Ketones, Aldehydes, Acids Source classification Phenols Plants Juglans mandshurica	Apoptosis NF-κB c-Met/HGFR Akt MMP
7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index .

HY-N10176

D-Isofloridoside	Cardiovascular Disease other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides	Reactive Oxygen Species MMP
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 ^[2].

HY-N0532R

Morroniside (Standard)	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	MMP Pyroptosis Apoptosis
Morroniside (Standard) is the analytical standard of Morroniside. This product is intended for research and analytical applications. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

HY-136699

Excisanin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Baccharis densiflora Wedd.	Others
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-N0431R

Astragaloside IV (Standard)	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	MMP ERK JNK
Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-N0069R

Solamargine (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Solanum Solanaceae Plants Saccharides Steroids	P-glycoprotein Apoptosis
Solamargine (Standard) is the analytical standard of Solamargine. This product is intended for research and analytical applications. Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity ^[2].

HY-N7385

Nudol	Orchidaceae Source classification Phenols Polyphenols Plants Epigeneium rotundatum (Lindl.) Summerh.	MMP Apoptosis
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits *MMP-2M* and *MMP-9* activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma ^[2].

HY-122506

Salviolone	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	STAT
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells .

HY-N0084

Betulinaldehyde 4 Publications Verification Betulinic aldehyde; Betunal	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Bacterial
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca ²⁺/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research ^[2] .

Recombinant Proteins Recommended:

MMP-2

Species:	Human (3) Mouse (1) Rat (1)
Tag:	His (4) Tag Free (1)
Source:	HEK293 (3) P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70268

	MMP-2 Protein, Human (HEK293, His) 3 Publications Verification rHu72 kDa type IV collagenase/MMP-2, His ; 72 kDa Type IV Collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; MMP-2; TBE-1; MMP2; CLG4A	Human	HEK293
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Human (HEK293, His) is the recombinant human-derived MMP-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-2 Protein, Human (HEK293, His) is 631 a.a., with molecular weight of 68-78 kDa.

HY-P73296

	MMP-2 Protein, Human (HEK293) 4 Publications Verification 72 kDa Type IV Collagenase; Gelatinase A; MMP-2; TBE-1; CLG4A	Human	HEK293
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Human (HEK293) is the recombinant human-derived MMP-2 protein, expressed by HEK293 , with tag free.

HY-P73810

	MMP-2 Protein, Mouse (HEK293, His) 2 Publications Verification 72 kDa Type IV Collagenase; Gelatinase A; MMP-2; TBE-1; CLG4A	Mouse	HEK293
	MMP-2 protein is a ubiquitous metalloprotease that contributes to vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to extracellular matrix degradation, it also targets non-matrix proteins and promotes vasoconstriction. MMP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P700573

	MMP-2 Protein, Rat (P. pastoris, His) rHu72 kDa type IV collagenase/MMP-2, His ; 72 kDa Type IV Collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; MMP-2; TBE-1; MMP2; CLG4A	Rat	P. pastoris
	MMP-2 is a multifunctional metalloproteinase that plays multiple roles in vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, MMP-2 also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Rat (P. pastoris, His) is the recombinant rat-derived MMP-2 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of MMP-2 Protein, Rat (P. pastoris, His) is 553 a.a., with molecular weight of 64.1 kDa.

HY-P700139AF

	*Animal-Free MMP-2* Protein, Human (His)** rHu72 kDa type IV collagenase/MMP-2, His ; 72 kDa Type IV Collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; MMP-2; TBE-1; MMP2; CLG4A	Human	E. coli
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. Animal-Free MMP-2 Protein, Human (His) is the recombinant human-derived animal-FreeMMP-2 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free MMP-2 Protein, Human (His) is 551 a.a., with molecular weight of ~63.00 kDa.

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HY-77813S

Benzyl isothiocyanate-d7
Benzyl isothiocyanate-d₇ is the deuterium labeled Benzyl isothiocyanate. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].

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HY-P80509

	MMP2 Antibody	WB, IHC-P	Human, Mouse
	MMP2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 72 kDa, targeting to MMP2. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

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MMP2

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