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NHE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/H+ Exchanger (NHE) (29) Autophagy (4) COX (4) Isotope-Labeled Compounds (1) NO Synthase (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) Prostaglandin Receptor (4) Sodium Channel (2) TRP Channel (4)
By Research Areas:	Cancer (6) Cardiovascular Disease (13) Inflammation/Immunology (6) Metabolic Disease (7) Neurological Disease (3)

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Isotope-Labeled Compounds

Targets Recommended: Na+/H+ Exchanger (NHE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100325

NHE3-IN-1	Na+/H+ Exchanger (NHE)	Neurological Disease
NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.

HY-139313

NHE3-IN-2	Na+/H+ Exchanger (NHE)	Metabolic Disease
NHE3-IN-2 is a Na ⁺/H ⁺ exchanger-3 (NHE3) inhibitor ( patent WO2001079186A1, example 6-Chlor-4-phenyl-2-chinazolinyl-guanidin) .

HY-105064D

Zoniporide hydrochloride hydrate 1 Publications Verification CP-597396 hydrochloride hydrate	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM) .

HY-151360

NHE3-IN-3	Sodium Channel	Metabolic Disease
NHE3-IN-3 (Compound 1) is a Na ⁺/H ⁺ exchanger isoform 3 (NHE3) inhibitor with pIC₅₀ of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats .

HY-105064B

Zoniporide hydrochloride CP-597396 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC₅₀=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC₅₀=59 nM) .

HY-105064DR

Zoniporide hydrochloride hydrate (Standard) CP-597396 hydrochloride hydrate (Standard)	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (hydrochloride hydrate) (Standard) is the analytical standard of Zoniporide (hydrochloride hydrate). This product is intended for research and analytical applications. Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM)[1][2].

HY-125144

BIIB 513	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
BIIB 513 is an inhibitor of NHE 1 that protects against myocardial ischemia. BIIB 513 inhibits acid load recovery with an IC₅₀ of 27 nmol/L in cells expressing wild-type NHE 1 under acute acid load .

HY-120623

BMS-284640	Na+/H+ Exchanger (NHE)	Neurological Disease
BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher *NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE*-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats. .

HY-132181

Dimethylamiloride hydrochloride	Na+/H+ Exchanger (NHE)	Inflammation/Immunology
Dimethylamiloride hydrochloride is a Na ⁺/H ⁺ exchanger *NHE* inhibitor with K_i values of 0.02, 0.25, and 14 μM for NHE1, NHE2, and NHE3, respectively. Dimethylamiloride hydrochloride can be used for pain research .

HY-13412

Cariporide (mesilate) HOE-642	Potassium Channel Sodium Channel	Cardiovascular Disease
Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1 .

HY-19273

Rimeporide 1 Publications Verification EMD-87580	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-19273A

Rimeporide hydrochloride EMD-87580 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-105064

Zoniporide 1 Publications Verification CP-597396	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) is a potent and selective *NHE-1* inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na ⁺ uptake by human *NHE-1*-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .

HY-105064C

Zoniporide dihydrochloride CP-597396 dihydrochloride	Na+/H+ Exchanger (NHE)	Cancer
Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a potent and selective inhibitor of highly water-soluble sodium hydrogen exchange type 1 (NHE-1). Zoniporide dihydrochloride inhibits *NHE1* dependent 22Na ⁺ uptake in vitro with an IC₅₀ of 14 nM. Zoniporide has antitumor activity .

HY-122525A

Sabiporide hydrochloride BIIB 722 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease Neurological Disease
Sabiporide hydrochloride is a *NHE-1* inhibitor (K_i: 50 nM). Sabiporide hydrochloride has cardioprotective and neuroprotective effects. Sabiporide hydrochloride inhibits glutamate- or NMDA-induced neuronal cell death .

HY-105064R

Zoniporide (Standard) CP-597396 (Standard)	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (Standard) is the analytical standard of Zoniporide. This product is intended for research and analytical applications. Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease[1].

HY-118778

KR-32568	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC₅₀ of 230 nM. KR-32568 has cardioprotective effects .

HY-W704968

2-Oxo-zoniporide hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
2-Oxo-zoniporide hydrochloride is an oral active sodium-hydrogen exchanger type 1 (NHE-1) inhibitor and can be used for study of myocardial ischemic injury .

HY-106150

Eniporide EMD-96785	Na+/H+ Exchanger (NHE)	Others
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

HY-W705589

Rimeporide-15N3 hydrochloride EMD-87580-¹⁵N₃ hydrochloride	Isotope-Labeled Compounds Na+/H+ Exchanger (NHE)	Metabolic Disease
Rimeporide- ¹⁵N₃ (hydrochloride) (EMD-87580- ¹⁵N₃ (hydrochloride)) is ¹⁵N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

HY-156696

S3226	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
S3226 is an inhibitor for Na+/H+ exchange subtype 3 (NHE3) with an IC₅₀ of 0.2 µmol/L in rat NHE3 transfected fibroblasts. S3226 exhibits protective activity in rat ischemia-induced acute renal failure models .

HY-18071A

BI-9627 hydrochloride 2 Publications Verification	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-18071

BI-9627 2 Publications Verification	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
BI-9627 is potent sodium-hydrogen exchanger isoform 1 *(NHE1)* inhibitor, with IC₅₀s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .

HY-163365

UTX-143	Na+/H+ Exchanger (NHE)	Cancer
UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity .

HY-15991A

Tenapanor hydrochloride 4 Publications Verification AZD1722 hydrochloride; RDX5791 hydrochloride	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia .

HY-15991

Tenapanor 4 Publications Verification AZD1722; RDX5791	Na+/H+ Exchanger (NHE)	Metabolic Disease
Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia .

HY-101840A

EIPA hydrochloride Maximum Cited Publications 53 Publications Verification L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride	TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-101840

EIPA Maximum Cited Publications 53 Publications Verification L593754; MH 12-43; Ethylisopropylamiloride	TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na ⁺/H ⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma .

HY-101840AR

EIPA hydrochloride (Standard) L593754 hydrochloride (Standard); MH 12-43 hydrochloride (Standard); Ethylisopropylamiloride hydrochloride (Standard)	TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (hydrochloride) (Standard) is the analytical standard of EIPA (hydrochloride). This product is intended for research and analytical applications. EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][5].

HY-101840R

EIPA (Standard) L593754 (Standard); MH 12-43 (Standard); Ethylisopropylamiloride (Standard)	TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)	Inflammation/Immunology Cancer
EIPA (Standard) is the analytical standard of EIPA. This product is intended for research and analytical applications. EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[1][2][3][4][5][6][7].

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase	Inflammation/Immunology
1,3,5-Trihydroxy-4-prenylxanthone is a Na ⁺/H ⁺ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

Cat. No.	Product Name	Type

HY-106150

Eniporide EMD-96785	Biochemical Assay Reagents
Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

Eniporide

EMD-96785

Biochemical Assay Reagents

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest .

Nhe I
MCE Nhe I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Bmt I.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Flavonoids Leguminosae Source classification Plants Other Flavonoids Erythrina variegata Linn.	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase
1,3,5-Trihydroxy-4-prenylxanthone is a Na ⁺/H ⁺ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

Cat. No.	Product Name	Chemical Structure

HY-W705589

Rimeporide-15N3 hydrochloride
Rimeporide- ¹⁵N₃ (hydrochloride) (EMD-87580- ¹⁵N₃ (hydrochloride)) is ¹⁵N labeled Rimeporide hydrochloride. Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na ⁺/H ⁺ exchanger (NHE-1).

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NHE

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