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Results for "

NS5B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (9) HBV (1) HCV (44) HCV Protease (4) Isotope-Labeled Compounds (2) Nucleoside Antimetabolite/Analog (2) Reverse Transcriptase (1) SARS-CoV (2) Virus Protease (1)
By Research Areas:	Infection (51) Inflammation/Immunology (2)
Oligonucleotides:	Nucleosides and their Analogs (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103487

Uprifosbuvir IDX21437; MK-3682	HCV	Infection
Uprifosbuvir is an antiviral agent. Uprifosbuvir is a NS5b inhibitor developed for the research of chronic hepatitis C virus .

HY-10544

Tegobuvir 4 Publications Verification GS 333126; GS-9190	HCV	Infection
Tegobuvir is a specific, covalent inhibitor of the *HCV NS5B polymerase*.

HY-12429

Beclabuvir 3 Publications Verification BMS-791325	HCV	Infection
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC₅₀ of < 28 nM .

HY-13465

VCH-916 1 Publications Verification	HCV	Infection
VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.

HY-145374

AL-611	HCV Protease	Infection
AL-611 is an HCV NS5B polymerase inhibitor (EC₅₀ = 5 nM).

HY-12429A

Beclabuvir hydrochloride BMS-791325 hydrochloride	HCV	Infection
Beclabuvir (BMS-791325) hydrochloride is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC₅₀ of < 28 nM .

HY-19643

JTK-109	HCV Protease	Infection
JTK-109 is a potent inhibitor of hepatitis C virus *NS5B* RNA-dependent RNA polymerase. JTK-109 has NS5B inhibitory activity with IC₅₀ value of 0.017μM. JTK-109 can be used for the research of hepatitis C virus (HCV) .

HY-10467

HCV-796 analog	Virus Protease	Infection
HCV-796 analog is a potent *NS5B* inhibitor that binds to the palm II site. HCV-796 analog is promising for research of hepatitis C (HCV) infections .

HY-109047

Adafosbuvir AL-335	HCV DNA/RNA Synthesis	Infection
Adafosbuvir (AL-335), a precursor compound of a uridine-based nucleotide analog polymerase (NS5B) inhibitor, has potent antiviral activity against HCV and acts as a potent inhibitor of HCV RNA polymerase .

HY-112047

GSK8175 GSK2878175	HCV	Infection
GSK8175 is a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV). GSK8175 is a sulfonamide- N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons .

HY-14775

Nesbuvir 5+ Cited Publications HCV-796	HCV	Infection
Nesbuvir is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase.

HY-12634

Deleobuvir BI 207127	HCV	Infection
Deleobuvir (BI 207127) is a potent non-nucleoside *hepatitis C virus (HCV) NS5B polymerase* inhibitor.

HY-124592

BMT-052	HCV	Infection
BMT-052 is a pan-genotypic hepatitis C (HCV) NS5B polymerase primer grip inhibitor .

HY-120233

MK-8876	HCV	Infection
MK-8876 is an inhibitor of *HCV NS5b site D*, which can be used in the research of hepatitis C virus .

HY-W753521

Deleobuvir sodium BI 207127 sodium	Others	Infection
Deleobuvir sodium (BI 207127 sodium) is a non-nucleoside hepatitis C virus NS5B polymerase inhibitor with anti-hepatitis C virus activity .

HY-111204

MK3281	HCV	Infection
MK3281 (Compound 33) is a non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor, with an EC₅₀ of 28 nM for gt1a .

HY-75800

Lomibuvir 2 Publications Verification VX-222	DNA/RNA Synthesis HCV	Infection
Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the *HCV NS5B polymerase (RdRp)* with a K_d of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC₅₀ of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis .

HY-16750

Radalbuvir GS-9669	HCV	Infection
Radalbuvir (GS-9669) is a non-nucleoside inhibitor of nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp). Radalbuvir shows strong anti-HCV potency (GT1a intrinsic EC₅₀ = 2.9 nM, GT1b EC₅₀ = 6 nM) .

HY-150760

GSK5852 GSK2485852	HCV	Inflammation/Immunology
GSK5852 (GSK2485852) is an HCV NS5B polymerase inhibitor, with an IC₅₀ value of 50 nM. GSK5852 displays antiviral activity and inhibits HCV with EC₅₀s of 3.0 nM (genotype 1a, GT1a) and 1.7 nM (GT1b), respectively .

HY-10165

PSI-6130 1 Publications Verification R 1656	HCV	Infection
PSI-6130 is a potent and selective inhibitor of *HCV NS5B polymerase, and inhibits HCV replication with a mean IC₅₀* of 0.6 μM.

HY-15745A

PSI-7409 tetrasodium 5+ Cited Publications	HCV	Infection
PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting *HCV NS5B polymerases, with IC₅₀s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5*B polymerases, respectively.

HY-10118

Filibuvir 2 Publications Verification	HCV DNA/RNA Synthesis	Infection
Filibuvir is an orally active, selective non-nucleoside inhibitor of the *HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp). Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5*B. Filibuvir inhibits genotype 1a and 1b replicons with EC₅₀s of 59 nM for both isoforms, respectively . Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation .

HY-14391

PSI-353661 GS-558093	HCV	Infection
PSI-353661 (GS-558093) is a purine nucleotide *NS5B* polymerase inhibitor against HCV infection. PSI-353661 shows EC₉₀s of 8 nM and 11 nM for wild type and S282T resistant replicons of HCV. PSI-353661 can produce high concentrations of the active triphosphate in primary human hepatocytes .

HY-10240

Mericitabine 5+ Cited Publications RG 7128; R-7128; PSI 6130 diisobutyrate	HCV	Infection
Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the *HCV NS5B polymerase* that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

HY-155832

HCV-IN-44	HCV	Infection
HCV-IN-44 (compound 28) is an HCV NS5B protein inhibitor that can effectively inhibit the replication of HCV virus. HCV-IN-44 can be used for the study of HCV infection .

HY-155831

HCV-IN-43	HCV	Infection
HCV-IN-43 (compound 2) is an HCV NS5B protein inhibitor that can effectively inhibit the replication of HCV virus. HCV-IN-43 can be used for the study of HCV infection .

HY-10468

NM107 2'-C-Methylcytidine	HCV	Infection
NM107 (2'-C-Methylcytidine) is an nucleoside inhibitor of the *hepatitis C virus (HCV) NS5B polymerase, the EC₅₀* of NM107 in the wild-type replicon cells is 1.85 μM .

HY-120634

BMS-929075	HCV	Infection
BMS-929075 is a potent and orally active *HCV NS5B replicase* palm site allosteric inhibitor. BMS-929075 shows high oral bioavailability. BMS-929075 shows cytotoxicity .

HY-13465A

VCH-916 free base	HCV	Infection
VCH-916 free base is the free base form of VCH-916 (HY-13465). VCH-916 free base is an inhibitor for non-nucleoside type NS5B HCV polymerase .

HY-108060

Valopicitabine NM283	HCV HCV Protease Nucleoside Antimetabolite/Analog	Infection
Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination .

HY-108060A

Valopicitabine dihydrochloride NM283 dihydrochloride	HCV HCV Protease Nucleoside Antimetabolite/Analog	Infection
Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits *NS5B* polymerase, causing chain termination .

HY-113659

3',5'-O-Bis(isobutiryl)-4'-azido-2'-β-C-methyl-2'-deoxycytidine	Others	Infection
3',5'-O-Bis(isobutyryl)-4'-azido-2'-β-C-methyl-2'-deoxycytidine functions as an NS5B inhibitor of RNA polymerase, and is utilized in the treatment of HCV infection.

HY-15591

TMC647055	HCV	Infection
TMC647055 is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 has potent HCV combine activity with an IC₅₀ value of 82 nM. TMC647055 can be used for the research of Hepatitis C virus (HCV) .

HY-101634

ABT-072	HCV	Infection
ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC₅₀=1 nM; HCV GT1b EC₅₀=0.3 nM) .

HY-101634A

ABT-072 potassium trihydrate	HCV	Infection
ABT-072 (potassium trihydrate) is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC₅₀=1 nM; HCV GT1b EC₅₀=0.3 nM) .

HY-15591A

TMC647055 Choline salt 1 Publications Verification	HCV	Infection
TMC647055 (Choline salt) is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 Choline salt has potent HCV combine activity with an IC₅₀ value of 82 nM. TMC647055 Choline salt can be used for the research of Hepatitis C virus (HCV) .

HY-W011834

2'-O-Methylcytidine	HCV	Infection
2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate .

HY-W128400

3′-Deoxy-3′-fluoroguanosine	DNA/RNA Synthesis HCV	Infection
3′-Deoxy-3′-fluoroguanosine exhibits antiviral activity against tick-borne encephalitis virus (TBEV), through interaction with NS5B RdRp of HCV, resulting in suppression of viral RNA synthesis by disruption of further extension of the replicating viral RNA .

HY-125473

IDX375	Others	Infection
IDX375 is a novel non-nucleoside inhibitor with selective inhibitory activity against HCV NS5B. IDX375 has good selectivity for genotypes 1a and 1b. The structure and binding site of IDX375 were confirmed by X-ray cocrystal studies .

HY-15236

PSI-6206 3 Publications Verification RO 2433; GS-331007	HCV	Infection
PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC₉₀ of >100 μM.

HY-13998

Dasabuvir Maximum Cited Publications 12 Publications Verification ABT-333	HCV DNA/RNA Synthesis	Infection
Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀ values of 7.7 and 1.8 nM, respectively .

HY-13998A

Dasabuvir sodium ABT-333 sodium	HCV DNA/RNA Synthesis	Infection
Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀ values of 7.7 and 1.8 nM, respectively .

HY-13247

Setrobuvir ANA598	DNA/RNA Synthesis HCV SARS-CoV	Infection
Setrobuvir (ANA598) is an orally active non-nucleosidic HCV *NS5B* polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC₅₀s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition .

HY-125371

2'-C-Methyladenosine 2 Publications Verification	HCV	Infection Inflammation/Immunology
2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC₅₀ values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis .

HY-W011834S

2'-O-Methylcytidine-d3	Isotope-Labeled Compounds HCV	Infection
2'-O-Methylcytidine-d₃ is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

HY-15236S

PSI-6206-13C,d3 RO-2433-¹³C,d₃; GS-331007-¹³C,d₃; Sofosbuvir metabolite GS-331007-¹³C,d₃	HCV	Infection
PSI-6206- ¹³C,d₃ is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.

HY-13998R

Dasabuvir (Standard)	HCV DNA/RNA Synthesis	Infection
Dasabuvir (Standard) is the analytical standard of Dasabuvir. This product is intended for research and analytical applications. Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀ values of 7.7 and 1.8 nM, respectively .

HY-131603

Lamivudine triphosphate 3TCTP	Reverse Transcriptase HCV HBV SARS-CoV	Infection
Lamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the Reverse Transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA .

HY-15236S1

PSI-6206-d1,13C,15N2 RO 2433--d¹,¹³C,¹⁵N₂; GS-331007--d¹,¹³C,¹⁵N₂	HCV Isotope-Labeled Compounds	Infection
PSI-6206-d1, ¹³C, ¹⁵N₂ is ¹⁵N and ¹³C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC₉₀ of >100 μM.

HY-14308

GS-9851 PSI-7851	Others	Infection
GS-9851 (PSI-7851) is an HCV nonstructural protein 5B (NS5B) inhibitor with potential activity for the treatment of HCV infection. GS-9851 showed good tolerability in patients with initial HCV genotype 1 infection. GS-9851 is rapidly cleared from the body with a half-life of approximately 1 hour. The maximum concentration of GS-9851 and the increase in the area under the compound concentration-time curve were not dose-proportional, especially at the highest dose .

Cat. No.	Product Name	Chemical Structure

HY-15236S

PSI-6206-13C,d3
PSI-6206- ¹³C,d₃ is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.

HY-124592

BMT-052
BMT-052 is a pan-genotypic hepatitis C (HCV) NS5B polymerase primer grip inhibitor .

HY-W011834S

2'-O-Methylcytidine-d3
2'-O-Methylcytidine-d₃ is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

HY-15236S1

PSI-6206-d1,13C,15N2
PSI-6206-d1, ¹³C, ¹⁵N₂ is ¹⁵N and ¹³C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC₉₀ of >100 μM.

Cat. No.	Product Name		Classification

HY-W011834

2'-O-Methylcytidine		Nucleosides and their Analogs
2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate .

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