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Results for "

Osteoclast formation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (7) Bacterial (4) Biochemical Assay Reagents (1) CGRP Receptor (1) DNA/RNA Synthesis (1) Dopamine β-hydroxylase (1) Drug Derivative (1) Endogenous Metabolite (1) ERK (1) HIV (1) Influenza Virus (1) MALT1 (1) Monoamine Oxidase (1) NF-κB (7) NOD-like Receptor (NLR) (1) Nuclear Factor of activated T Cells (NFAT) (2) p38 MAPK (3) PI3K (1) PPAR (1) Proton Pump (3) RANKL/RANK (7) Reactive Oxygen Species (ROS) (2) Reference Standards (5) Thyroid Hormone Receptor (1) VD/VDR (1) VSV (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Endocrinology (1) Infection (5) Inflammation/Immunology (11) Metabolic Disease (7) Neurological Disease (1)

By Targets:

Akt (1)

Apoptosis (7)

Bacterial (4)

Biochemical Assay Reagents (1)

CGRP Receptor (1)

DNA/RNA Synthesis (1)

Dopamine β-hydroxylase (1)

Drug Derivative (1)

Endogenous Metabolite (1)

ERK (1)

HIV (1)

Influenza Virus (1)

MALT1 (1)

Monoamine Oxidase (1)

NF-κB (7)

NOD-like Receptor (NLR) (1)

Nuclear Factor of activated T Cells (NFAT) (2)

p38 MAPK (3)

PI3K (1)

PPAR (1)

Proton Pump (3)

RANKL/RANK (7)

Reactive Oxygen Species (ROS) (2)

Reference Standards (5)

Thyroid Hormone Receptor (1)

VD/VDR (1)

VSV (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (5)

Inflammation/Immunology (11)

Metabolic Disease (7)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130237

Cinnamtannin B-1	Reactive Oxygen Species (ROS) NF-κB Apoptosis	Metabolic Disease Cancer
Cinnamtannin B-1 is a anthocyanidin. Cinnamtannin B-1 inhibits the osteoclast formation by inhibiting NF-kB signaling pathway and ROS generation. Cinnamtannin B-1 exhibits antioxidant, anti-inflammatory, antitumor and anti-platelet aggregation activities. Cinnamtannin B-1 is orally active .

HY-N2465

Methylsticin	Others	Inflammation/Immunology
Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity .

HY-N10117

2,3-Bis(3-indolylmethyl)indole	RANKL/RANK	Others
2,3-Bis(3-indolylmethyl)indole significantly suppresses RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner.

HY-N0499

Cyanidin Chloride 3 Publications Verification IdB 1027	RANKL/RANK	Cancer
Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression .

HY-N8215

Achyranthoside C	Others	Metabolic Disease
Achyranthoside C is a saponin from Achyranthes bidentata. The derivative of Achyranthoside C has inhibitory activity on osteoclast formation .

HY-N2528

Usnic acid sodium	Bacterial	Infection Cancer
Usnic acid sodium, a lichen-derived secondary metabolite, has a unique dibenzofuran skeleton. Usnic acid sodium has excellent anticancer and antimicrobial properties. Usnic acid sodium significantly inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1 .

HY-130237R

Cinnamtannin B-1 (Standard)	Reference Standards Reactive Oxygen Species (ROS) NF-κB Apoptosis	Metabolic Disease Cancer
Cinnamtannin B-1 (Standard) is the analytical standard of Cinnamtannin B-1. This product is intended for research and analytical applications. Cinnamtannin B-1 is a anthocyanidin. Cinnamtannin B-1 inhibits the osteoclast formation by inhibiting NF-kB signaling pathway and ROS generation. Cinnamtannin B-1 exhibits antioxidant, anti-inflammatory, antitumor and anti-platelet aggregation activities. Cinnamtannin B-1 is orally active .

HY-122019

ABD56	NF-κB ERK Apoptosis	Others
ABD56 is a compound that induces osteoclast apoptosis and has the activity of inhibiting osteoclast formation and inducing apoptosis. ABD56 can inhibit osteoclast formation and induce apoptosis, and its mechanism is related to the inhibition of NFκB and ERK pathways.

HY-103303

CRSP-1	CGRP Receptor	Metabolic Disease
CRSP-1 is short for calcitonin receptor-stimulating peptide-1. CRSP-1 inhibits osteoclast formation by inhibiting the formation and activity of multinucleated osteoclast .

HY-155977

Anti-osteoporosis agent-5	Others	Others
Anti-osteoporosis agent-5 (compound 189) is a potent inhibitor of the formation of osteoclasts .

HY-49069

Anti-osteoporosis agent-7	Drug Derivative	Others
Anti-osteoporosis agent-7 (Compound 133) is a potential anti-osteoporosis agent showing high inhibition of osteoclast formation.

HY-168090

Anti-osteoporosis agent-11	p38 MAPK NF-κB RANKL/RANK	Endocrinology
Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC₅₀ value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways .

HY-P10078

pTH (39-84) (human)	Thyroid Hormone Receptor	Inflammation/Immunology
pTH (39-84) (human) is a parathyroid hormone (PTH) C-terminal fragment. pTH (39-84) (human) stimulates osteoclast formation .

HY-N0499R

Cyanidin Chloride (Standard) IdB 1027 (Standard)	Reference Standards RANKL/RANK	Cancer
Cyanidin (Chloride) (Standard) is the analytical standard of Cyanidin (Chloride). This product is intended for research and analytical applications. Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression .

HY-N10062

Amakusamine	RANKL/RANK	Others
Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

HY-N2465R

Methylsticin (Standard)	Reference Standards Others	Inflammation/Immunology
Methylsticin (Standard) is the analytical standard of Methylsticin. This product is intended for research and analytical applications. Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity .

HY-155985

Anti-osteoporosis agent-6	Others	Metabolic Disease
Anti-osteoporosis agent-6 (compound 174) is an anti-osteoporosis agent. Anti-osteoporosis agent-6 has 14.11% inhibition rate against osteoclast formation at 10 μM .

HY-118668

ABD-350	NF-κB	Others
ABD-350 is an antiresorptive agent that inhibits osteoclast activity without affecting osteoblast activity and preventing ovariectomy-induced bone loss. ABD-350 inhibits NF-κB ligand-induced inhibitor of NF-κB phosphorylation, leading to osteoclast apoptosis, but has no inhibitory effect on osteoblast function, effectively preventing bone loss in ovariectomized mice, and does not inhibit parathyroid hormone-induced bone formation.

HY-169703

SPA0355	RANKL/RANK p38 MAPK Akt NF-κB	Inflammation/Immunology
SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis .

HY-149472

Anti-osteoporosis agent-4	NF-κB PI3K	Inflammation/Immunology
Anti-osteoporosis agent-4 (Compound 11h) inhibits differentiation of primary osteoclasts. Anti-osteoporosis agent-4 attenuates RANKL-induced osteoclastogenesis. Anti-osteoporosis agent-4 inhibits osteoclast formation with an IC₅₀ value of 358.29 nM. Anti-osteoporosis agent-4 inhibits PI3K/AKT and IκBα/NF-κB signaling pathway activation .

HY-121282B

Mepazine acetate Pecazine acetate	Apoptosis MALT1	Others
Mepazine acetate (Pecazine acetate) is a drug that has the activity to inhibit the protease activity of MALT1. Mepazine acetate is often used to study the role of MALT1 in biology. Treatment of mouse bone marrow precursor cells with mepazine acetate strongly inhibited RANK ligand (RANKL)-induced osteoclast formation. Mepazine acetate also inhibited the expression of multiple osteoclast markers such as TRAP, feline hepsin K, and calcitonin. The protective effect of mepazine acetate was not affected by MALT1 deficiency. The mechanism of action of mepazine acetate may involve MALT1-independent mechanisms, and this aspect needs to be considered in future studies .

HY-N2532

Diphyllin	VSV HIV Proton Pump Influenza Virus	Infection Inflammation/Immunology Cancer
Diphyllin is an orally active V-ATPase inhibitor (IC₅₀=17 nM) and HIV-1 inhibitor (IC₅₀=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC₅₀=0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption .

HY-147369

NFATc1-IN-1 2 Publications Verification	Nuclear Factor of activated T Cells (NFAT)	Others
NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced *osteoclast* formation, with an IC₅₀ of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research .

HY-B1246

Thonzonium bromide 5 Publications Verification	Bacterial Proton Pump	Infection
Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC₅₀=69 μM) .

HY-N0656

Usnic acid 1 Publications Verification	Bacterial DNA/RNA Synthesis Nuclear Factor of activated T Cells (NFAT) Apoptosis	Infection Inflammation/Immunology Cancer
Usnic acid is a secondary metabolite of lichens with a unique dibenzofuran skeleton. Usnic acid inhibits DNA/RNA synthesis and has antibacterial activity. Usnic acid induces cell cycle arrest and apoptosis and has anticancer activity. Usnic acid inhibits RANKL-mediated osteoclast formation and function by reducing the transcriptional and translational expression of NFATc1. Usnic acid has antioxidant and anti-inflammatory activities by inhibiting lipid peroxidation and myeloperoxidase .

HY-127090

Muramyl dipeptide 4 Publications Verification MDP	p38 MAPK NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist .

HY-168336

E0924G	PPAR	Metabolic Disease
E0924G is an orally active activator for PPARδ with EC₅₀ of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC₅₀ of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models .

HY-N6973

Boldine 1 Publications Verification	RANKL/RANK Apoptosis	Inflammation/Immunology Cancer
Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research .

HY-B1246R

Thonzonium bromide (Standard)	Reference Standards Bacterial Proton Pump	Infection
Thonzonium (bromide) (Standard) is the analytical standard of Thonzonium (bromide). This product is intended for research and analytical applications. Thonzonium bromide is an antibacterial agent that is structurally similar to Farnesol (HY-Y0248A). Thonzonium bromide is also a monocationic surface-active agent, which inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo. Thonzonium bromide inhibits proton transport in a dose-dependent manner (EC₅₀=69 μM) .

HY-B2221C

CM Cellulose CM-32 Carboxymethyl cellulose CM-32; CM-32	Biochemical Assay Reagents	Others
CM Cellulose CM-32 (Carboxymethyl cellulose) is a cellulose derivative. CM Cellulose CM-32 has a wide range of applications in the biomedical field, including tissue engineering, wound dressing, absorbent nonwovens, fabrication of 3D-scaffolds for biocompatible implants, artificial organs or mimics of extracellular polymeric matrix and diagnosis of various diseases. CM Cellulose CM-32 can decrease *osteoclasts* formation. CM Cellulose CM-32 can be used as a biological material or organic compound for life science related research .

HY-112499

Menaquinone-7 1 Publications Verification Vitamin K2-7; Vitamin K2(35); Vitamin MK-7	Others	Cardiovascular Disease
Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .

HY-12398

TEI-9647 1 Publications Verification	VD/VDR	Metabolic Disease Inflammation/Immunology
TEI-9647, a Vitamin D₃ Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease .

HY-112499R

Menaquinone-7 (Standard) Vitamin K2-7(Standard); Vitamin K2(35)(Standard); Vitamin MK-7 (Standard)	Endogenous Metabolite Reference Standards	Cardiovascular Disease
Menaquinone-7 (Standard) is the analytical standard of Menaquinone-7. This product is intended for research and analytical applications. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis	Neurological Disease Inflammation/Immunology
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

Cat. No.	Product Name	Type

HY-B2221C

CM Cellulose CM-32 Carboxymethyl cellulose CM-32; CM-32	Filter Medium
CM Cellulose CM-32 (Carboxymethyl cellulose) is a cellulose derivative. CM Cellulose CM-32 has a wide range of applications in the biomedical field, including tissue engineering, wound dressing, absorbent nonwovens, fabrication of 3D-scaffolds for biocompatible implants, artificial organs or mimics of extracellular polymeric matrix and diagnosis of various diseases. CM Cellulose CM-32 can decrease *osteoclasts* formation. CM Cellulose CM-32 can be used as a biological material or organic compound for life science related research .

CM Cellulose CM-32

Carboxymethyl cellulose CM-32; CM-32

Filter Medium

CM Cellulose CM-32 (Carboxymethyl cellulose) is a cellulose derivative. CM Cellulose CM-32 has a wide range of applications in the biomedical field, including tissue engineering, wound dressing, absorbent nonwovens, fabrication of 3D-scaffolds for biocompatible implants, artificial organs or mimics of extracellular polymeric matrix and diagnosis of various diseases. CM Cellulose CM-32 can decrease osteoclasts formation. CM Cellulose CM-32 can be used as a biological material or organic compound for life science related research .

pTH (39-84) (human)	Thyroid Hormone Receptor	Inflammation/Immunology
pTH (39-84) (human) is a parathyroid hormone (PTH) C-terminal fragment. pTH (39-84) (human) stimulates osteoclast formation .

CRSP-1	CGRP Receptor	Metabolic Disease
CRSP-1 is short for calcitonin receptor-stimulating peptide-1. CRSP-1 inhibits osteoclast formation by inhibiting the formation and activity of multinucleated osteoclast .

Cinnamtannin B-1	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Reactive Oxygen Species (ROS) NF-κB Apoptosis
Cinnamtannin B-1 is a anthocyanidin. Cinnamtannin B-1 inhibits the osteoclast formation by inhibiting NF-kB signaling pathway and ROS generation. Cinnamtannin B-1 exhibits antioxidant, anti-inflammatory, antitumor and anti-platelet aggregation activities. Cinnamtannin B-1 is orally active .

Methylsticin	Structural Classification Classification of Application Fields Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity .

2,3-Bis(3-indolylmethyl)indole	Alkaloids Structural Classification Hordeum vulgare var. coeleste Linnaeus Classification of Application Fields Gramineae Source classification Other Diseases Plants Disease Research Fields Indole Alkaloids	RANKL/RANK
2,3-Bis(3-indolylmethyl)indole significantly suppresses RANKL-induced osteoclast formation, actin ring formation, and bone resorption in a concentration-dependent manner.

Cyanidin Chloride 3 Publications Verification IdB 1027	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Anthocyans Flavonoids Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	RANKL/RANK
Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression .

Diphyllin	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Plants Infection Monophenols Phenols Phenylpropanoids Berberidaceae Inflammation/Immunology Disease Research Fields	VSV HIV Proton Pump Influenza Virus
Diphyllin is an orally active V-ATPase inhibitor (IC₅₀=17 nM) and HIV-1 inhibitor (IC₅₀=0.38 μM). Diphyllin blocks the acidification of osteoclast lysosomes and bone resorption lacunas (IC₅₀=0.6 nM for acid influx inhibition)， thereby inhibiting bone resorption. Diphyllin can effectively inhibit osteoclast-mediated bone resorption and has no effect on osteoblastic bone formation. Diphyllin can be used in the research of bone metabolism-related diseases and has the potential to inhibit diseases related to excessive bone resorption .

Achyranthoside C	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Metabolic Disease Amaranthaceae Plants Disease Research Fields Achyranthes bidentata	Others
Achyranthoside C is a saponin from Achyranthes bidentata. The derivative of Achyranthoside C has inhibitory activity on osteoclast formation .

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