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BRD6688 is a selective HDAC2 inhibitor. BRD6688 increases H4K12 and H3K9 histone acetylation in primary mouse neuronal cells. BRD6688 crosses the blood brain barrier and rescues the memory defects associated with p25 induced neurodegeneration in contextual fear conditioning in a CK-p25 mouse model .
5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively .
CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD) .
(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model .
Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 µM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM.
DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease .
OM137 is an aurora kinase inhibitor, with an IC50 of 21.7 μM (Aurora A kinase) and 2.4 μM (Aurora B kinase). OM137 also inhibits Cdk1/cyclinB and Cdk5/p25 with an approximate IC50 of 20 μM. OM137 reduces spindle checkpoint-signaling proteins (Mad2 and BubR1) at the kinetochores of chromosomes .
PF-46396 is a potent HIV-1 inhibitor with an EC50 value of 0.206 µM. PF-46396 shows antiviral activity. PF-46396 inhibits the processing of capsid (CA)/spacer peptide 1 (SP1) (p25) Gag precursor proteins and blocks maturation of the viral core particle .
(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM) .
CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor .
Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.
(S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40 μM) .
CDK9/10/GSK3β-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits HsGSK3β (IC50=59 nM), HsCDK9/CyclinT (IC50=64 nM), HsCDK5/p25 (IC50=1.093 µM) and HsCDK2/CyclinA (IC50=1.725 µM). CDK9/10/GSK3β-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3β-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines .
(R)-CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect . (R)-CR8 acts as a molecular glue degrader that depletes cyclin K .
(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect . (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K .
mmu-miR-3102-5p.2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
mmu-miR-3102-5p.2-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
mmu-miR-3102-5p.2-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
mmu-miR-3102-5p.2-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
TMED9, a key player in vesicular protein trafficking, operates prominently in the early secretory pathway, specifically in COPI vesicle-mediated retrograde transport. It facilitates coatomer recruitment to membranes, enhances ARFGAP2 activity, and ensures specific retention of p24 complexes in cis-Golgi membranes, notably influencing TMED2 and TMED10 localization. Beyond retrograde transport, TMED9 contributes to intracellular membrane organization, including the ER-Golgi intermediate compartment and Golgi apparatus, and participates in PTPN2 isoform PTPB ER localization. TMED9's dynamic oligomeric states involve monomers and homodimers, influenced by its interactions with EMP24/GP25L family members (TMED2, TMED7, and TMED10) and specific associations with TMED5, COPG1, PTPN2, SPAST, and STX17. TMED9 Protein, Human (HEK293, His) is the recombinant human-derived TMED9 protein, expressed by HEK293, with C-His labeled tag. The total length of TMED9 Protein, Human (HEK293, His) is 165 a.a., with molecular weight of ~20.8 kDa.
Lipocalin-2/NGAL Protein, Mouse (HEK293, His) is an 20-28 kDa NGAL protein with a His-flag, which is expressed in HEK293 cells. NGAL is an antibacterial factor of natural immunity, and an acute-phase protein.
Lipocalin-2/NGAL is a multifaceted iron transporter involved in multiple biological processes, including apoptosis, innate immunity, and kidney development. Lipocalin-2 dynamically affects cellular iron concentration through binding to the siderophore 2,3-dihydroxybenzoate. Lipocalin-2/NGAL Protein, Rat (sf9, His) is the recombinant rat-derived Lipocalin-2/NGAL protein, expressed by Sf9 insect cells , with C-His labeled tag.
Lipocalin-2/NGAL is an iron transporter that plays a crucial role in various cellular processes. It interacts with the siderophore 2,3-DHBA to transport iron into or out of cells depending on cellular needs. Lipocalin-2/NGAL Protein, Human (HEK293, His) is the recombinant human-derived Lipocalin-2/NGAL protein, expressed by HEK293 , with C-6*His labeled tag.
The eIF3K protein is an important component of the eukaryotic translation initiation factor 3 (eIF-3) complex and plays a crucial role in various steps of protein synthesis initiation.It stimulates recruitment of mRNA to the 43S preinitiation complex (43S PIC) and promotes AUG recognition scanning.EIF3K Protein, Human (sf9, His-GST) is the recombinant human-derived EIF3K protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
Lipocalin-2/NGAL Protein, Mouse (HEK293, His) is an 20-28 kDa NGAL protein with a His-flag, which is expressed in HEK293 cells. NGAL is an antibacterial factor of natural immunity, and an acute-phase protein.
The TPPP2 protein may be a regulator of microtubule dynamics and is critical for sperm motility. Unlike other family members, TPPP2 lacks microtubule bundling activity, suggesting a unique functional role. TPPP2 Protein, Human (His) is the recombinant human-derived TPPP2 protein, expressed by E. coli , with N-His labeled tag. The total length of TPPP2 Protein, Human (His) is 170 a.a., with molecular weight of 18-21 kDa.
TMED9, a key player in vesicular protein trafficking, operates prominently in the early secretory pathway, specifically in COPI vesicle-mediated retrograde transport. It facilitates coatomer recruitment to membranes, enhances ARFGAP2 activity, and ensures specific retention of p24 complexes in cis-Golgi membranes, notably influencing TMED2 and TMED10 localization. Beyond retrograde transport, TMED9 contributes to intracellular membrane organization, including the ER-Golgi intermediate compartment and Golgi apparatus, and participates in PTPN2 isoform PTPB ER localization. TMED9's dynamic oligomeric states involve monomers and homodimers, influenced by its interactions with EMP24/GP25L family members (TMED2, TMED7, and TMED10) and specific associations with TMED5, COPG1, PTPN2, SPAST, and STX17. TMED9 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED9 protein, expressed by HEK293, with C-mFc labeled tag. The total length of TMED9 Protein, Human (HEK293, Fc) is 202 a.a., with molecular weight of ~45.8 kDa.
Lipocalin-2/NGAL, an iron-trafficking protein, interacts with 2,3-DHBA and modulates cellular iron levels.It acts as a conveyor or extractor of iron, depending on the cellular context.Lipocalin-2/NGAL can increase intracellular iron concentration or reduce it, affecting apoptosis and innate immunity.It can also bind siderophores from M.tuberculosis and exist as a monomer, homodimer, or heterodimer with MMP9.Lipocalin-2/NGAL Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Lipocalin-2/NGAL protein, expressed by HEK293 , with C-hFc labeled tag.
Lipocalin-2/NGAL is a multifaceted iron transporter involved in multiple biological processes, including apoptosis, innate immunity, and kidney development. Lipocalin-2 dynamically affects cellular iron concentration through binding to the siderophore 2,3-dihydroxybenzoate. Lipocalin-2/NGAL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Lipocalin-2/NGAL protein, expressed by HEK293 , with C-His labeled tag. The total length of Lipocalin-2/NGAL Protein, Cynomolgus (HEK293, His) is 178 a.a., with molecular weight of 25-30 kDa.
CDK5 is a proline-directed serine/threonine protein kinase that critically regulates neuronal cell cycle, differentiation and potential apoptosis in neuronal diseases by preventing cell cycle re-entry. It interacts with numerous proteins involved in neuronal development and coordinates processes such as survival, migration, differentiation, axonal growth, synaptogenesis, and neurotransmission. CDK5-p25 Protein, Human (sf9, GST, His, Flag) is the recombinant human-derived CDK5-p25, expressed by Sf9 insect cells , with N-GST, N-His, N-Flag labeled tag. ,
Lipocalin 2 Antibody (YA992) is a biotin-conjugated non-conjugated IgG antibody, targeting Lipocalin 2, with a predicted molecular weight of 23 kDa. Lipocalin 2 Antibody (YA992) can be used for WB, IHC-P, ICC/IF experiment in human background.
p24; P25; P25alpha; TPPP; TPPP/P25; TPPP1; Tubulin polymerization promoting protein
WB, IHC-P, ICC/IF, FC
Human, Mouse, Rat
TPPP Antibody (YA2185) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2185), targeting TPPP, with a predicted molecular weight of 24 kDa (observed band size: 24 kDa). TPPP Antibody (YA2185) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.
Lipocalin 2 Antibody (YA991) is a biotin-conjugated non-conjugated IgG1 antibody, targeting Lipocalin 2. Lipocalin 2 Antibody (YA991) can be used for ELISA experiment in human, rat background.
CBX5; HP1A; Chromobox protein homolog 5; Antigen P25; Heterochromatin protein 1 homolog alpha; HP1 alpha
WB, IHC-F, IHC-P, ICC/IF
Human, Mouse, Rat
HP1 alpha Antibody (YA981) is a mouse-derived non-conjugated IgG2b antibody (Clone NO.: YA981), targeting HP1 alpha, with a predicted molecular weight of 22 kDa (observed band size: 26 kDa). HP1 alpha Antibody (YA981) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.
CBX5; HP1A; Chromobox protein homolog 5; Antigen P25; Heterochromatin protein 1 homolog alpha; HP1 alpha
WB, IHC-P
Human, Rat, Mouse
HP1 alpha Antibody (YA982) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA982), targeting HP1 alpha, with a predicted molecular weight of 22 kDa (observed band size: 22 kDa). HP1 alpha Antibody (YA982) can be used for WB, IHC-P experiment in human, rat, mouse background.
CBX5; HP1A; Chromobox protein homolog 5; Antigen P25; Heterochromatin protein 1 homolog alpha; HP1 alpha
WB, IHC-F, IHC-P, ICC/IF, IP
Human, Mouse, Rat
HP1 alpha Antibody (YA983) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA983), targeting HP1 alpha, with a predicted molecular weight of 22 kDa (observed band size: 22 kDa). HP1 alpha Antibody (YA983) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
Dynactin Subunit 5 Antibody (YA1990) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1990), targeting Dynactin Subunit 5, with a predicted molecular weight of 20 kDa (observed band size: 20 kDa). Dynactin Subunit 5 Antibody (YA1990) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.
mmu-miR-3102-5p.2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
mmu-miR-3102-5p.2-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
mmu-miR-3102-5p.2-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
mmu-miR-3102-5p.2-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.
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