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Isoforms Recommended:	PI3Kγ

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PI3K-γ

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By Targets:	PI3K (87) Akt (3) Apoptosis (24) ATM/ATR (1) Autophagy (15) CDK (1) DNA-PK (4) EGFR (1) Epigenetic Reader Domain (2) HDAC (1) Isotope-Labeled Compounds (2) Mitophagy (7) mTOR (21) PARP (1) PI4K (2) PPAR (1) PROTACs (1) Reactive Oxygen Species (6) Virus Protease (1)
By Research Areas:	Cancer (83) Inflammation/Immunology (15) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: PI3K

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111570

PI3Kγ inhibitor AZ2 1 Publications Verification	PI3K	Inflammation/Immunology
PI3Kγ inhibitor AZ2 is a highly selective PI3Kγ inhibitor (The pIC₅₀ value for PI3Kγ is 9.3). PI3Kγ inhibitor AZ2 can be used for the research of inflammatory and immune diseases .

HY-11080

PKI-179	PI3K mTOR	Cancer
PKI-179 is a potent and orally active dual *PI3K/mTOR* inhibitor, with IC₅₀s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for *PI3K-α, PI3K-β, PI3K-γ, PI3K-δ* and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC₅₀s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo .

HY-11080A

PKI-179 hydrochloride	PI3K mTOR	Cancer
PKI-179 hydrochloride is a potent and orally active dual *PI3K/mTOR* inhibitor, with IC₅₀s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for *PI3K-α, PI3K-β, PI3K-γ, PI3K-δ* and mTOR, respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R, with IC₅₀s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo .

HY-13530

CAY10505 3 Publications Verification	PI3K Apoptosis	Cancer
CAY10505 is a potent and selective PI3Kγ inhibitor with an IC₅₀ of 30 nM in neurons.

HY-132299

PI3Kγ inhibitor 4	PI3K	Inflammation/Immunology
PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC₅₀ of 40 nM. PI3Kγ inhibitor 4 shows ∼7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation .

HY-148317

PI3Kγ inhibitor 6	PI3K	Inflammation/Immunology
PI3Kγ inhibitor 6 (compound 9) is a PI3Kγ inhibitor. PI3Kγ inhibitor 6 can be used for the research of inflammatory and autoimmune diseases .

HY-139880

PI3Kγ inhibitor 5	PI3K	Cancer
PI3Kγ inhibitor 5 is an inhibitor of phosphoinositide 3-kinase γ *(PI3Kγ)* with an IC₅₀ value of 34 nM.

HY-112286

PI3Kγ inhibitor 2	PI3K	Inflammation/Immunology
PI3Kγ inhibitor 2 (Compound 16) is an orally bioavailable, CNS-penetrant, isoform selective PI3Kγ inhibitor with a K_i of 4 nM .

HY-153703

PI3Kγ inhibitor 7	PI3K	Cancer
PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC₅₀ values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity . PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10549

PI3Kγ inhibitor 1	PI3K	Cancer
PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC₅₀s of <100 nM.

HY-13532

AS-252424 3 Publications Verification	PI3K	Cancer
AS-252424 is a potent and selective PI3Kγ inhibitor with an IC₅₀ of 30±10 nM.

HY-112443

AZD3458	PI3K	Metabolic Disease Inflammation/Immunology Cancer
AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC₅₀s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively .

HY-10109

AS-605240 5 Publications Verification	PI3K Autophagy	Cancer
AS-605240 is a specific and orally active inhibitor of the PI3Kγ, with an IC₅₀ of 8 nM, and a K_i of 7.8 nM.

HY-15294

CZC24832	PI3K	Inflammation/Immunology Cancer
CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC₅₀=27 nM) with apparent dissociation constants (K_d ^app) of 19 nM.

HY-112897

IITZ-01	Autophagy PI3K Apoptosis	Cancer
IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC₅₀ of 2.62 μM for PI3Kγ.

HY-13531

AS-604850 1 Publications Verification	PI3K	Cancer
AS-604850 is a potent, selective and ATP-competitive PI3Kγ inhibitor with an IC₅₀ value of 0.25 μM and a K_i value of 0.18 μM. AS-604850 shows isoform selective inhibitor of PI3Kγ with over 30-fold selectivity for PI3Kδ and β, and 18-fold selectivity over PI3Kα, respectively .

HY-16122A

CAL-130	PI3K	Cancer
CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC₅₀s of 1.3 and 6.1 nM, respectively.

HY-16122B

CAL-130 Hydrochloride	PI3K	Cancer
CAL-130 is a PI3Kδ and PI3Kγ inhibitor with IC₅₀s of 1.3 and 6.1 nM, respectively.

HY-17645

Tenalisib 1 Publications Verification RP6530	PI3K	Cancer
Tenalisib (RP6530) is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC₅₀ values of 25 and 33 nM, respectively.

HY-161366

OMS14	PI3K	Cancer
OMS14 is exhibits inhibitory activity for phosphoinositide 3-kinase γ (PI3Kγ) and *PIK3CD/PIK3R1, which inhibits 19% PI3Kγ and 65% PIK3*CD/PIK3R1 activity at 100 μM. OMS14 exhibits anticancer efficacy in various cancer cells .

HY-100716

Eganelisib 15+ Cited Publications IPI-549	PI3K	Cancer
Eganelisib (IPI549) is a potent and selective PI3Kγ inhibitor with an IC₅₀ of 16 nM. Eganelisib shows >100-fold selectivity over other lipid and protein kinases .

HY-D0254

Gallein 4 Publications Verification Pyrogallol phthalein	PI3K	Cancer
Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity ^[1][3].

HY-112172

Tenalisib R Enantiomer RP6530 R Enantiomer	PI3K	Cancer
Tenalisib R Enantiomer (RP6530 R Enantiomer) is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC₅₀ values of 25 and 33 nM, respectively .

HY-133907

NVS-PI3-4	PI3K	Inflammation/Immunology Cancer
NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases .

HY-120438

TASP0415914	PI3K Akt	Inflammation/Immunology
TASP0415914 is a potent and orally active PI3Kγ inhibitor with an IC₅₀ of 29 nM. TASP0415914 also shows potent Akt inhibitory activities with an IC₅₀ of 294 nM. TASP0415914 can be used for inflammatory diseases research .

HY-12046

PIK-93 4 Publications Verification	PI4K PI3K Virus Protease	Cancer
PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC₅₀ of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC₅₀ of 16 nM and 39 nM, respectively.

HY-101146

SF2523 2 Publications Verification	PI3K Epigenetic Reader Domain DNA-PK	Cancer
SF2523 is a highly selective and potent inhibitor of *PI3K* with IC₅₀s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.

HY-50847

ZSTK474 15+ Cited Publications	PI3K Autophagy	Cancer
ZSTK474 is an ATP-competitive pan-class I *PI3K* inhibitor with IC₅₀s of 16 nM, 44 nM, 4.6 nM and 49 nM for PΙ3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively.

HY-13333

NVP-BAG956 BAG 956	PI3K	Cancer
NVP-BAG956 is an ATP-competitive *PI3K* inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.

HY-18085

Quercetin Maximum Cited Publications 81 Publications Verification	Reactive Oxygen Species PI3K Autophagy Mitophagy Apoptosis	Cancer
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-10681

Gedatolisib 4 Publications Verification PKI-587; PF-05212384	PI3K mTOR	Cancer
Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively . Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .

HY-18085A

Quercetin hydrate	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species	Cancer
Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-19962

Paxalisib 2 Publications Verification GDC-0084	PI3K mTOR	Cancer
Paxalisib (GDC-0084) is a brain penetrant inhibitor of *PI3K* and mTOR, with K_is of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively .

HY-16526

Pilaralisib 4 Publications Verification XL-147; SAR245408	PI3K	Cancer
Pilaralisib (XL147; SAR245408) is a potent and highly selective class I *PI3Ks inhibitor with IC₅₀s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3*Kδ.

HY-N0146

Quercetin dihydrate Maximum Cited Publications 81 Publications Verification	PI3K Apoptosis	Inflammation/Immunology Cancer
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a *PI3K* inhibitor with *IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .*

HY-15271

WYE-687 3 Publications Verification	mTOR PI3K	Cancer
WYE-687 is an ATP-competitive mTOR inhibitor with an IC₅₀ of 7 nM. WYE-687 concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits PI3Kα and PI3Kγ with IC₅₀s of 81 nM and 3.11 μM, respectively.

HY-13898

Taselisib 15+ Cited Publications GDC-0032; RG-7604	PI3K	Cancer
Taselisib (GDC-0032) is a potent *PI3K* inhibitor targets PIK3CA mutations, with K_is of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.

HY-19798

PI4KIIIbeta-IN-9 5 Publications Verification	PI4K PI3K	Cancer
PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC₅₀ of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC₅₀s of 152 nM and 1046 nM, respectively.

HY-15271A

WYE-687 dihydrochloride	mTOR PI3K	Cancer
WYE-687 dihydrochloride is an ATP-competitive mTOR inhibitor with an IC₅₀ of 7 nM . WYE-687 dihydrochloride concurrently inhibits activation of mTORC1 and mTORC2 . WYE-687 also inhibits PI3Kα and PI3Kγ with IC₅₀s of 81 nM and 3.11 μM, respectively .

HY-147419

Vulolisib	PI3K	Cancer
Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC₅₀ values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity .

HY-10811

GNE-493	PI3K mTOR	Cancer
GNE-493 is a potent, selective, and orally available dual *pan-PI3-kinase/mTOR* inhibitor with IC₅₀s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.

HY-13431

KU-0060648 2 Publications Verification	DNA-PK PI3K mTOR	Cancer
KU-0060648 is a dual inhibitor of *PI3K* and DNA-PK with IC₅₀s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively .

HY-13334

BGT226 maleate 5+ Cited Publications NVP-BGT226 maleate	PI3K mTOR Autophagy Apoptosis	Cancer
BGT226 (NVP-BGT226 maleate) is a *PI3K* (with IC₅₀s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ) /mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells .

HY-12330

AZD8186 5 Publications Verification	PI3K	Cancer
AZD8186 is a *PI3K* inhibitor, which potently inhibits PI3Kβ (IC₅₀=4 nM) and PI3Kδ (IC50₅₀=12 nM) with selectivity over PI3Kα (IC₅₀=35 nM) and PI3Kγ (IC₅₀=675 nM).

HY-18085S1

Quercetin-d3	Isotope-Labeled Compounds PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis	Cancer
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-101517

PI3K-IN-2	PI3K	Cancer
PI3K-IN-2 (compound 10) is a potent and orally active PI3Kβ/δ (IC₅₀=7.1/8.6 nM) inhibitor with excellent selectivity versus PI3Kσ and PI3Kγ (IC₅₀=13/190 nM, respectively) .

HY-18085S

Quercetin-d5	PI3K Autophagy Mitophagy Apoptosis	Cancer
Quercetin-d₅ is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-12034

WYE-354 5+ Cited Publications	mTOR Autophagy Apoptosis	Cancer
WYE-354 is an ATP-competitive mTOR inhibitor with an IC₅₀ of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC₅₀s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro ^[3].

HY-18085S2

Quercetin-13C3	Isotope-Labeled Compounds PI3K Autophagy Mitophagy Reactive Oxygen Species Apoptosis	Cancer
Quercetin- ¹³C₃ is the ¹³C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-143404

PI3K-IN-30	PI3K	Cancer
PI3K-IN-30 (compound 6d) is a potent *PI3K* inhibitor with IC₅₀s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18085

Quercetin Maximum Cited Publications 81 Publications Verification	Flavonols Structural Classification Classification of Application Fields Anti-aging Source classification Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Sunscreen Disease markers Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Reactive Oxygen Species PI3K Autophagy Mitophagy Apoptosis
Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0146

Quercetin dihydrate Maximum Cited Publications 81 Publications Verification	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	PI3K Apoptosis
Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a *PI3K* inhibitor with *IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .*

HY-N0451

Acacetin 5+ Cited Publications 5,7-Dihydroxy-4'-methoxyflavone	Structural Classification Neurological Disease Classification of Application Fields Flavones Anti-aging Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

HY-18085A

Quercetin hydrate	Structural Classification Flavonols Flavonoids other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	PI3K Autophagy Mitophagy Apoptosis Reactive Oxygen Species
Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀ of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085R

Quercetin (Standard)	Flavonols Structural Classification Source classification Endocrine diseases Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Immune System Disorder Microorganisms other families Leguminosae Disease markers Glycyrrhiza uralensis Fisch.	Reactive Oxygen Species PI3K Autophagy Mitophagy Apoptosis
Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0146R

Quercetin dihydrate (Standard)	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	PI3K Apoptosis
Quercetin (dihydrate) (Standard) is the analytical standard of Quercetin (dihydrate). This product is intended for research and analytical applications. Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-N0451R

Acacetin (Standard) 5,7-Dihydroxy-4'-methoxyflavone (Standard)	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Phenols Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy
Acacetin (Standard) is the analytical standard of Acacetin. This product is intended for research and analytical applications. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an orally active flavonoid derived from Dendranthema morifolium. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research .

Cat. No.	Product Name	Chemical Structure

HY-18085AS

Quercetin-d3 hydrate
Quercetin-d3 hydrate is a deuterium labeled Quercetin hydrate (HY-18085A), a flavonoid which can stimulate recombinant SIRT1 and also a *PI3K* inhibitor with IC₅₀s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively .

HY-18085S1

Quercetin-d3
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-18085S

Quercetin-d5
Quercetin-d₅ is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-18085S2

Quercetin-13C3
Quercetin- ¹³C₃ is the ¹³C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

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PI3K-γ

Inhibitors & Agonists

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Isotope-Labeled Compounds

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