2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. EGFR PI3K PPAR
  4. MTX-531

MTX-531 is a potent and selective inhibitor of EGFR and PI3K, with IC50s of 14.7 nM and 1.1-233 nM (differ in subtype). MTX-531 can also act as a weak agonist of PPARγ, with the EC50 of 3.4 μM in 293H cells.

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MTX-531 Chemical Structure

MTX-531 Chemical Structure

CAS No. : 2791417-66-6

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MTX-531 Related Antibodies

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Description

MTX-531 is a potent and selective inhibitor of EGFR and PI3K, with IC50s of 14.7 nM and 1.1-233 nM (differ in subtype). MTX-531 can also act as a weak agonist of PPARγ, with the EC50 of 3.4 μM in 293H cells[1].

IC50 & Target

PI3Kα

6.4 nM (IC50)

PI3Kβ

233 nM (IC50)

PI3Kδ

1.1 nM (IC50)

PI3Kγ

8.3 nM (IC50)

PPARγ

3.4 μM (EC50)

Molecular Weight

453.94

Formula

C22H20ClN5O2S
CAS No.
SMILES

ClC1=C(NS(=O)(C)=O)C=C(C2=CC3=C(N=CN=C3N[C@@H](C4=CC=CC=C4)C)C=C2)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MTX-531 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTX-5312791417-66-6MTX531MTX 531EGFRPI3KPPAREpidermal growth factor receptorErbB-1HER1Phosphoinositide 3-kinasePeroxisome proliferator-activated receptorssquamous head and neck patient-derived xenograft (PDX) modelsCRCInhibitorinhibitorinhibit

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