Search Result
Results for "
Penicillium
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
2
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-120551
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Others
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Others
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Fructigenine A (compound 4) is a active product that can be isolated from marine-derived Penicillium sp. .
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-
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- HY-N12184
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Others
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Others
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Peniciside is a triterpenoid glycoside derived from the fungus Penicillium sp.169 .
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-
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- HY-129591
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PNU-97333
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Others
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Others
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Paraherquamide A (PNU-97333) is a toxic metabolite that can be isolated from Penicillium paraherquei .
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-
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- HY-N12904
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(+)-Communesin B; Nomofungin
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Others
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Cancer
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Communesin B ((+)-Communesin B; Nomofungin) has cytotoxicity and can be isolated from Penicillium .
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-
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- HY-126697
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-
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- HY-N12911
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Others
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Others
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Tanzawaic acid E is a carboxylic acid and can be isolated from Penicillium steckii .
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-
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- HY-126484
-
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Fungal
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Others
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Eremofortin B is a sesquiterpenoid compound synthesized by penicillium roqueforti PR Toxin (PRT) .
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-
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- HY-116479
-
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Bacterial
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Others
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Citromycetin is an aromatic polyketide compound from Australian marine-derived and terrestrial Penicillium spp .
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-
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- HY-W741556
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Antibiotic
Fungal
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Infection
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Dehydrogriseofulvin can be isolated from Penicillium sp. Dehydrogriseofulvin inhibits Colletotrichum musae with MIC > 1 µg/scrip.
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-
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- HY-N12266
-
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Others
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Others
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12-Hydroxyalbrassitriol is a drimane sesquiterpenoid that can be isolated from Penicillium sp .
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-
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- HY-129279
-
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Farnesyl Transferase
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Cancer
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Andrastin A meroterpenoid compound, is a farnesyltransferase inhibitor. Andrastin A inhibits the efflux of anticancer compounds from multidrug-resistant cancer cells. Andrastin A can be isolated from Penicillium species .
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-
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- HY-N7480A
-
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Cholinesterase (ChE)
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Neurological Disease
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Quinolactacin A1 is a potent acetylcholinesterase (AChE) inhibitor from solid state fermentation of Penicillium citrinum 90648. Quinolactacin A1 can be used for the research of Alzheimer disease .
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-
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- HY-P3043
-
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Opioid Receptor
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Neurological Disease
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Bilaid A is a μ-opioid receptor agonist that can be extracted from Penicillium. The Ki value is 3.1 μM. Bilaid A can be used in pain research .
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-
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- HY-N12914
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(+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid E
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Reactive Oxygen Species
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Others
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Tanzawaic acid B ((+)-Tanzawaic acid B; GS-1302-1; 10-Deoxytanzawaic acid E) is a superoxide anion production inhibitor and can be isolated from Penicillium citrinum .
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-
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- HY-126604
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Others
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Infection
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Pyranonigrin A is isolated and identified from Penicillium brocae MA-231. Pyranonigrin A shows potent activity against a broad spectrum of human-, aqua-, and plant-pathogens .
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-
-
- HY-129806
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(+)-Rugulosin
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Bacterial
Fungal
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Infection
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Rugulosin is a crystalline colouring matter of Penicillium rugulosum Thom. Rugulosin shows markedly specific antibacterial activity and moderately antifungal activity .
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-
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- HY-N8287
-
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Microtubule/Tubulin
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Cancer
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Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase .
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-
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- HY-130757
-
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Endogenous Metabolite
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Inflammation/Immunology
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Remisporine B is a polyketide, that can be isolated from Penicillium sp. ZJ-SY2. Remisporine B exhibits immunosuppressive efficacy, that inhibits concanavalin A (HY-P2149)-induced T-cell proliferation and LPS (HY-D1056)- induced B-cell proliferations of mouse splenic lymphocytes with IC50 of 30.1 µg/mL and 32.4 µg/mL .
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-
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- HY-122076
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Antibiotic
Bacterial
Fungal
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Infection
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A-26771B is an antibiotic can be obtained from Penicillium turbatum. A-26771B exhibits moderate antimicrobial activity against Gram-positive bacteria, mycoplasma, and fungi. A-26771B also inhibits potassium-dependent ATPase in rat liver mitochondria .
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-
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- HY-W099579
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Kojic dipalmitate
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Tyrosinase
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Endocrinology
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Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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-
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- HY-N6748
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-
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- HY-N12761
-
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Phosphatase
Glycosidase
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Metabolic Disease
Inflammation/Immunology
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Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity .
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-
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- HY-N12165
-
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Others
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Others
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1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .
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-
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- HY-118463
-
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Neurokinin Receptor
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Neurological Disease
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Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with Ki values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively .
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-
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- HY-W099579R
-
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Tyrosinase
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Endocrinology
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Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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-
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- HY-N10177
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HSV
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Infection
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Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits HSV-1/2 virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2 .
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-
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- HY-P10329
-
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Fungal
|
Infection
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KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
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-
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- HY-P5591
-
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Fungal
|
Infection
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PAF26 is an antimicrobial peptide against phytopathogenic fungi Penicillium digitatum, Penicillium italicum and Botrytis cinerea .
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-
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- HY-N10215
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-
-
- HY-121332
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-
-
- HY-133001
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-
-
- HY-136871
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-
-
- HY-N7221
-
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Fungal
|
Infection
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Janthitrem G is a microbial metabolite that can be isolated from cultures of Penicillium .
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-
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- HY-N8548
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-
-
- HY-125298
-
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Parasite
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Infection
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Cycloaspeptide A, isolated from the endophytic fungus Penicillium janczewskii, has antiparasitic activity .
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-
-
- HY-172191
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-
-
- HY-N11955
-
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Others
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Others
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Cyclo(Ile-Leu) is a Alkaloids product that can be isolated from From Penicillium oxalicum .
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-
-
- HY-123474
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-
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- HY-129208
-
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Antibiotic
Fungal
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Infection
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Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
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-
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- HY-120154
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(±)-Palitantin
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Parasite
Endogenous Metabolite
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Infection
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Palitantin ((±)-Palitantin), a metabolite of Penicillium frequentans on Leishmania brasiliensis, has antiprotozoal effect against Leishmania brasiliensis .
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-
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- HY-125546
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Antibiotic
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Infection
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Erythromycin C is an antibiotic. Erythromycin C could be isolated from the fermentation process of the penicillium Streptomyces erythreus .
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-
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- HY-121163
-
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Fungal
|
Infection
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Janthitrem F is a metabolite isolated from tremorigen-producing Penicillium and a potential causative agent of ryegrass spurt disease.
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-
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- HY-N10220
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-
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- HY-N13086
-
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Others
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Others
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Peniviridiol A (compound4) is a viridin derivative that can be isolated from rhizosphere fungus Penicillium sp. SMU0102 .
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-
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- HY-N7222
-
|
Fungal
|
Infection
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Janthitrem F is a metabolite isolated from tremorigen-producing Penicillium and a potential causative agent of ryegrass spurt disease .
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-
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- HY-125060
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-
-
- HY-129384
-
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Endogenous Metabolite
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Cancer
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Rubratoxin B is a hepatotoxic mycotoxin that can be found in Penicillium rubrum Stoll. Rubratoxin B shows antitumor activity .
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-
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- HY-124301
-
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Bacterial
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Infection
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Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .
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-
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- HY-122404
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Xanthocillin X
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MEK
ERK
Autophagy
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Cancer
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Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway .
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-
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- HY-N10442
-
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Others
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Others
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Herqueilenone A is a benzoquinone-chromanon that can be found in the Hawaiian volcanic soil-associated fungal strain Penicillium herquei FT729[1].
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-
- HY-N14665
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Antibiotic
Bacterial
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Infection
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Atrovenetin is an antibiotic found in Penicillium species. Atrovenetin has inhibitory activity against Bacillus subtilis and Staphylococcus aureus. Atrovenetin is also a potent antioxidant.
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- HY-126983
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Epoxybergamottin
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Cytochrome P450
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Others
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6',7'-Epoxybergamottin is a metabolism of Penicillium digitatum. 6',7'-Epoxybergamottin can be used in study the cytochrome P450 3A4 inhibitory activity .
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- HY-116812
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Insecticide
|
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Sclerotigenin is an anti-insect benzodiazepine compound identified in Penicillium sclerotigenum (NRRL 3461). Sclerotigenin exhibits significant anti-insect activity against crop pest Helicoverpa zea .
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- HY-N12700
-
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Parasite
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Infection
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Puberulic acid Ⅰ possesses anti-malarial activity with an IC50 value of 0.050 µM against Plasmodium falciparum K1 (chloroquine-resistant) .
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- HY-122062R
-
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Insecticide
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Others
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Erythromycin C (Standard) is the analytical standard of Erythromycin C. This product is intended for research and analytical applications. Erythromycin C is an antibiotic. Erythromycin C could be isolated from the fermentation process of the penicillium Streptomyces erythreus .
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- HY-125546R
-
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Antibiotic
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Infection
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Erythromycin C (Standard) is the analytical standard of Erythromycin C. This product is intended for research and analytical applications. Erythromycin C is an antibiotic. Erythromycin C could be isolated from the fermentation process of the penicillium Streptomyces erythreus .
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-
- HY-N12169
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11,12-Epoxyjanthitrem B
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Others
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Neurological Disease
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Janthitrem A (11,12-Epoxyjanthitrem B) is a natural product that can be isolated from Penicillium janthinellum. Janthitrem A induces tremors in mice and reduces weight gain and food consumption of porina (Wiseana cervinata) larvae .
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- HY-N8498
-
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Apoptosis
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Cancer
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GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .
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- HY-116474
-
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Fungal
|
Infection
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Viridicatol, a quinolinone alkaloid, is isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. Viridicatol has strong antifungal activity against Staphylococcus aureus with MIC value of 15.6 μg/mL .
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- HY-75564
-
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Endogenous Metabolite
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Cancer
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Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM .
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- HY-N6688
-
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Potassium Channel
Bacterial
Antibiotic
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Infection
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Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca 2+-activated K + channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle .
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- HY-N6777
-
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Caspase
Bacterial
Apoptosis
Antibiotic
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Infection
Cancer
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Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .
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- HY-N6744
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Apoptosis
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Infection
Cancer
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Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration .
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- HY-P4107
-
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Opioid Receptor
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Neurological Disease
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Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (Ki=210 nM, hMOPr) .
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- HY-121234
-
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Bacterial
DNA/RNA Synthesis
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Infection
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Botryodiplodin is a mycotoxin isolated from Penicillium roqueforti. Botryodiplodin inhibits the growth of some Gram-positive and Gram-negative bacteria and can also induce DNA-protein cross-links in mammalian cells, inhibiting the synthesis of DNA, RNA, and protein .
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- HY-N6779
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Patulin
3 Publications Verification
Terinin
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Bacterial
Apoptosis
Autophagy
Antibiotic
|
Infection
|
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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- HY-P3519
-
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Drug Intermediate
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Others
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ACV Tripeptide is a key biosynthetic precursor of penicillin and cephalosporins and is found in Penicillium chrysogenum and Acremonium chrysogenum. ACV Tripeptide is synthesized by a large non-ribosomal peptide synthase called ACV synthase, which is encoded by the 11 kb The pchAB gene encodes this enzyme .
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- HY-116498
-
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Others
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Infection
|
Penigequinolone A is an alkaloid isolated from Penicillium. It is lethal to P. penetrans (LD50=100 mg/L) but has no effect on C. elegans at concentrations up to 1000 mg/L.1 Penigequinolone A also accelerates the root growth of rice seedlings in a dose-dependent manner.
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- HY-126775
-
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Mitochondrial Metabolism
Endogenous Metabolite
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Cancer
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Xenoclauxin is a secondary metabolite isolated from certain species of the Penicillium genus, which exhibits an inhibitory effect on the proliferation of tumor cells. Xenoclauxin affects cellular energy metabolism, particularly by inhibiting ATP synthesis in the mitochondria. Xenoclauxin can be used for anti-tumor research .
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- HY-117517
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Trk Receptor
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Cancer
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NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .
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- HY-P3044
-
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Opioid Receptor
|
Neurological Disease
|
Bilaid A1e (Compound 1e) is a tetrapeptide agonist of the µ-opioid receptor (Ki = 750 nM). Bilaid A1e can be isolated from an Australian estuarine isolate of Penicillium sp. Bilaid A1e can be used for pain research .
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- HY-N6027
-
|
Fungal
Bacterial
|
Infection
|
Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. Cyclosporin C is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs=0.1-5 μg/ml).
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- HY-N6797
-
|
Bacterial
c-Met/HGFR
Antibiotic
|
Infection
Cancer
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Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies .
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- HY-P3519A
-
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Drug Intermediate
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Others
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ACV Tripeptide TFA is the TFA form of ACV Tripeptide (HY-P3519). ACV Tripeptide TFA is a key biosynthetic precursor of penicillin and cephalosporins and is found in Penicillium chrysogenum and Acremonium chrysogenum. ACV Tripeptide TFA is synthesized by a large non-ribosomal peptide synthase called ACV synthase .
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- HY-P2032
-
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Endogenous Metabolite
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Infection
Cancer
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Cyclochlorotine is a mycotoxin that can be extracted from the yellow rice infectant Penicillium islandicum Sopp. Cyclochlorotine promotes glycogenolysis, inhibits glycogen synthesis, affects fat synthesis and protein synthesis in liver cells. Cyclochlorotine exhibits chronic toxicity in liver that induces liver fibrosis and cirrhosis in mouse models. Cyclochlorotine exhibits carcinogenicity .
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- HY-N6776
-
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Potassium Channel
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Neurological Disease
Cancer
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Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .
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- HY-N6745
-
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Na+/K+ ATPase
Apoptosis
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Infection
Cardiovascular Disease
|
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na +/K +-ATPase whereas in microsomes, both Na +/K +-ATPase and Mg 2+-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .
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- HY-123457
-
|
Fungal
|
Infection
|
PF-1163A is an antifungal agent that inhibits Ergosterol (HY-N0181) synthesis (IC50 = 12 ng/mL), which is found in a fermentation broth of Penicillium sp. PF-1163A also inhibits C-4 sterol methyl oxidase with an MIC value of 12.5 µg/mL .
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- HY-N6779R
-
|
Bacterial
Apoptosis
Autophagy
Antibiotic
|
Infection
|
Patulin (Standard) is the analytical standard of Patulin. This product is intended for research and analytical applications. Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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- HY-N8316
-
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Others
|
Infection
|
Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5, and 200 μg/mL, respectively.1 Rugulotrosin A is inactive against Gram-negative bacteria.
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-
- HY-121624
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Glutathione S-transferase
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Infection
|
Anthglutin is a gamma-glutamyltransferase inhibitor isolated from Penicillium oxalicum cultures. The Ki values ??of Anthglutin for different enzymes are: porcine kidney enzyme 5.7 μM, human kidney enzyme 18.3 μM, human liver soluble enzyme 13.6 μM, and conjugated enzyme 10.2 μM. Anthglutin had no significant effect on intestinal absorption of methionine in rats .
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- HY-N12726
-
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p38 MAPK
MMP
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Infection
Inflammation/Immunology
Cancer
|
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum.
Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .
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- HY-N4096R
-
|
Others
|
Inflammation/Immunology
|
Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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-
- HY-N6779S
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Terinin-13C7
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Isotope-Labeled Compounds
|
Infection
|
Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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- HY-116866
-
|
Lipoxygenase
Fungal
|
Infection
Inflammation/Immunology
|
Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans .
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- HY-122306
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Mycotrienin II
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin .
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- HY-116620
-
|
Neurokinin Receptor
|
Infection
|
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
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-
- HY-W015912S
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2-Furyl methyl ketone-d3
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Isotope-Labeled Compounds
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Others
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2-Acetylfuran-d3 is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na +/K +-ATPase whereas in microsomes, both Na +/K +-ATPase and Mg 2+-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .
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- HY-N6778
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Paxilline
Maximum Cited Publications
6 Publications Verification
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Potassium Channel
Calcium Channel
Reactive Oxygen Species
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Neurological Disease
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Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca 2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .
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- HY-114881
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NSC 246118
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Fungal
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Infection
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Frequentin, a secondary metabolite produced by Penicillium janthinellum, is influenced by environmental conditions such as cadmium nitrate and sodium chloride concentrations. In cadmium nitrate-free medium, P. janthinellum produces cyclopenin, carlosic acid, erythroskyrin, kojic acid, and patulin. At 100 ppm cadmium nitrate, it produces cyclopenin, carlosic acid, frequentin, and islandicin. In the presence of sodium chloride, frequentin is produced at 2% and 3% concentrations. These findings indicate that frequentin production is sensitive to specific environmental stressors, highlighting its potential variability under different growth conditions .
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- HY-P2963
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Endogenous Metabolite
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Others
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Nuclease P1 is a single-stranded specific endonuclease, it hydrolyzes nucleic acids into 5'-mononucleotides and cleaves the single-stranded region of a double-stranded nucleic acid. Nuclease P1 is one of the most well-known single stranded specific nucleases in the field of molecular biology, it is widely used in the pharmaceutical and food industries . Nuclease P1 can be obtained by fermentation of Penicillium citrinum: through extraction process, ultrafiltration concentration, drying and purification, etc.
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- HY-N15310
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Drug Metabolite
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Others
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Dimerum acid is a dihydroxamate-type siderophore found in Penicillium chrysogenum. It serves as a precursor or degradation product of coprogen and effectively enhances iron uptake in strategy I plants (e.g., cucumber) and strategy II plants (e.g., maize). Under pH 6.0 conditions, Dimerum acid facilitates the release of bioavailable Fe 3+ through ligand exchange with plant-secreted phytosiderophores (PS) or EDTA, thereby improving plant iron supply efficiency. Dimerum acid can be used for research in the fields of plant iron nutrition and agriculture .
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- HY-117235
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- HY-117235R
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Cat. No. |
Product Name |
Type |
Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P5591
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Fungal
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Infection
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PAF26 is an antimicrobial peptide against phytopathogenic fungi Penicillium digitatum, Penicillium italicum and Botrytis cinerea .
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- HY-P3519A
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Drug Intermediate
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Others
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ACV Tripeptide TFA is the TFA form of ACV Tripeptide (HY-P3519). ACV Tripeptide TFA is a key biosynthetic precursor of penicillin and cephalosporins and is found in Penicillium chrysogenum and Acremonium chrysogenum. ACV Tripeptide TFA is synthesized by a large non-ribosomal peptide synthase called ACV synthase .
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- HY-P5941
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Peptides
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Others
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Bilaid C1 is a tetrapeptide isolated from Penicillium sp .
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- HY-P3043
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Opioid Receptor
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Neurological Disease
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Bilaid A is a μ-opioid receptor agonist that can be extracted from Penicillium. The Ki value is 3.1 μM. Bilaid A can be used in pain research .
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- HY-P10329
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Fungal
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Infection
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KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
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- HY-P4107
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Opioid Receptor
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Neurological Disease
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Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective μ-Opioid Receptor (MOPr) agonist (Ki=210 nM, hMOPr) .
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- HY-P3519
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Drug Intermediate
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Others
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ACV Tripeptide is a key biosynthetic precursor of penicillin and cephalosporins and is found in Penicillium chrysogenum and Acremonium chrysogenum. ACV Tripeptide is synthesized by a large non-ribosomal peptide synthase called ACV synthase, which is encoded by the 11 kb The pchAB gene encodes this enzyme .
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- HY-P3044
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Opioid Receptor
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Neurological Disease
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Bilaid A1e (Compound 1e) is a tetrapeptide agonist of the µ-opioid receptor (Ki = 750 nM). Bilaid A1e can be isolated from an Australian estuarine isolate of Penicillium sp. Bilaid A1e can be used for pain research .
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- HY-P2032
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Endogenous Metabolite
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Infection
Cancer
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Cyclochlorotine is a mycotoxin that can be extracted from the yellow rice infectant Penicillium islandicum Sopp. Cyclochlorotine promotes glycogenolysis, inhibits glycogen synthesis, affects fat synthesis and protein synthesis in liver cells. Cyclochlorotine exhibits chronic toxicity in liver that induces liver fibrosis and cirrhosis in mouse models. Cyclochlorotine exhibits carcinogenicity .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N6797
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- HY-P2032
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Structural Classification
Microorganisms
Cyclopeptides
Source classification
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Endogenous Metabolite
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Cyclochlorotine is a mycotoxin that can be extracted from the yellow rice infectant Penicillium islandicum Sopp. Cyclochlorotine promotes glycogenolysis, inhibits glycogen synthesis, affects fat synthesis and protein synthesis in liver cells. Cyclochlorotine exhibits chronic toxicity in liver that induces liver fibrosis and cirrhosis in mouse models. Cyclochlorotine exhibits carcinogenicity .
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- HY-N6776
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Structural Classification
Microorganisms
Terpenoids
Source classification
Diterpenoids
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Potassium Channel
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Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .
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-
- HY-N6745
-
-
- HY-N6779R
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-
- HY-N8316
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-
- HY-121624
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-
- HY-N12726
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-
- HY-N4096R
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-
- HY-116866
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|
Structural Classification
Natural Products
Microorganisms
Source classification
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Lipoxygenase
Fungal
|
Sclerotiorin is a reversible and uncompetitive inhibitor against soybean lipoxygenase-1 (LOX-1) (IC50: 4.2 μM). Sclerotiorin also shows antioxidant activity by scavenging free radical (ED50: 0.12 μM), and nonenzymatic lipid peroxidation inhibition activity. Sclerotiorin has antifungal activity, and also inhibits platelet aggregation. Sclerotiorin can be purified from the fermented broth of Penicillium frequentans .
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-
- HY-116620
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-
- HY-N6778
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-
- HY-114881
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NSC 246118
|
Structural Classification
Microorganisms
Antibiotics
Source classification
Other Antibiotics
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Fungal
|
Frequentin, a secondary metabolite produced by Penicillium janthinellum, is influenced by environmental conditions such as cadmium nitrate and sodium chloride concentrations. In cadmium nitrate-free medium, P. janthinellum produces cyclopenin, carlosic acid, erythroskyrin, kojic acid, and patulin. At 100 ppm cadmium nitrate, it produces cyclopenin, carlosic acid, frequentin, and islandicin. In the presence of sodium chloride, frequentin is produced at 2% and 3% concentrations. These findings indicate that frequentin production is sensitive to specific environmental stressors, highlighting its potential variability under different growth conditions .
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-
- HY-N15310
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Drug Metabolite
|
Dimerum acid is a dihydroxamate-type siderophore found in Penicillium chrysogenum. It serves as a precursor or degradation product of coprogen and effectively enhances iron uptake in strategy I plants (e.g., cucumber) and strategy II plants (e.g., maize). Under pH 6.0 conditions, Dimerum acid facilitates the release of bioavailable Fe 3+ through ligand exchange with plant-secreted phytosiderophores (PS) or EDTA, thereby improving plant iron supply efficiency. Dimerum acid can be used for research in the fields of plant iron nutrition and agriculture .
|
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- HY-117235
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-
- HY-117235R
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-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-N6779S
-
|
Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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-
-
- HY-W015912S
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2-Acetylfuran-d3 is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na +/K +-ATPase whereas in microsomes, both Na +/K +-ATPase and Mg 2+-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .
|
-
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